Mark R. Davies
Mark R. Davies
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Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing
GR Mirams, MR Davies, Y Cui, P Kohl, D Noble
British journal of pharmacology 167 (5), 932-945, 2012
Prediction of thorough QT study results using action potential simulations based on ion channel screens
GR Mirams, MR Davies, SJ Brough, MH Bridgland-Taylor, Y Cui, ...
Journal of pharmacological and toxicological methods 70 (3), 246-254, 2014
An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment
MR Davies, HB Mistry, L Hussein, CE Pollard, JP Valentin, J Swinton, ...
American Journal of Physiology-Heart and Circulatory Physiology 302 (7 …, 2012
Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
RC Elkins, MR Davies, SJ Brough, DJ Gavaghan, Y Cui, N Abi-Gerges, ...
Journal of pharmacological and toxicological methods 68 (1), 112-122, 2013
High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment
GY Di Veroli, MR Davies, H Zhang, N Abi-Gerges, MR Boyett
American Journal of Physiology-Heart and Circulatory Physiology 304 (1 …, 2013
Recent developments in using mechanistic cardiac modelling for drug safety evaluation
MR Davies, K Wang, GR Mirams, A Caruso, D Noble, A Walz, T Lavé, ...
Drug discovery today 21 (6), 924-938, 2016
hERG inhibitors with similar potency but different binding kinetics do not pose the same proarrhythmic risk: implications for drug safety assessment
GY Di Veroli, MR Davies, H Zhang, N ABI‐GERGES, MR Boyett
Journal of cardiovascular electrophysiology 25 (2), 197-207, 2014
Harvesting the promise of AOPs: An assessment and recommendations
A Carusi, MR Davies, G De Grandis, BI Escher, G Hodges, KMY Leung, ...
Science of the Total Environment 628, 1542-1556, 2018
Capacity limits of asialoglycoprotein receptor-mediated liver targeting
C Bon, T Hofer, A Bousquet-Mélou, MR Davies, BF Krippendorff
MAbs 9 (8), 1360-1369, 2017
The Na+/K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue
C Sánchez, A Corrias, A Bueno-Orovio, M Davies, J Swinton, I Jacobson, ...
American Journal of Physiology-Heart and Circulatory Physiology 302 (5 …, 2012
Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts
MR Davies, CJ Harding, S Raines, K Tolley, AE Parker, M Downey-Jones, ...
Journal of Inflammation 2 (1), 15, 2005
Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop
B Rodriguez, A Carusi, N Abi-Gerges, R Ariga, O Britton, G Bub, ...
Ep Europace 18 (9), 1287-1298, 2015
Ligands for retinoic acid receptors are elevated in osteoarthritis and may contribute to pathologic processes in the osteoarthritic joint
MR Davies, LR Ribeiro, M Downey‐Jones, MRC Needham, C Oakley, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2009
Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis
S Stahl, MR Davies, DI Cook, MJ Graham
Xenobiotica 38 (7-8), 725-777, 2008
Methodologies for quantitative systems pharmacology (QSP) models: design and estimation
B Ribba, HP Grimm, B Agoram, MR Davies, K Gadkar, S Niederer, ...
CPT: pharmacometrics & systems pharmacology 6 (8), 496-498, 2017
A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment
HB Mistry, MR Davies, GY Di Veroli
Frontiers in pharmacology 6, 59, 2015
Hierarchical Bayesian modelling of variability and uncertainty in synthetic action potential traces
RH Johnstone, R Bardenet, DJ Gavaghan, L Polonchuk, MR Davies, ...
2016 Computing in Cardiology Conference (CinC), 1089-1092, 2016
Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk
MR Davies, M Martinec, R Walls, R Schwarz, GR Mirams, K Wang, ...
Cell Reports Medicine 1 (5), 100076, 2020
Hierarchical Bayesian fitting of concentration-effect models to ion channel screening data
R Johnstone, R Bardenet, L Polonchuk, M Davies, D Gavaghan, ...
Journal of Pharmacological and Toxicological Methods 88, 198, 2017
DJ Gallacher, G Gintant, N Abi‐Gerges, MR Davies, HR Lu, KM Hoagland, ...
Drug Discovery Toxicology: From Target Assessment to Translational …, 2016
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