| DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells X Zhang, J Su, M Jeong, M Ko, Y Huang, HJ Park, A Guzman, Y Lei, ... Nature genetics 48 (9), 1014-1023, 2016 | 250 | 2016 |
| Mutant NPM1 maintains the leukemic state through HOX expression L Brunetti, MC Gundry, D Sorcini, AG Guzman, YH Huang, ... Cancer cell 34 (3), 499-512. e9, 2018 | 239 | 2018 |
| DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A YH Huang, J Su, Y Lei, L Brunetti, MC Gundry, X Zhang, M Jeong, W Li, ... Genome biology 18 (1), 176, 2017 | 215 | 2017 |
| Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein Y Lei, X Zhang, J Su, M Jeong, MC Gundry, YH Huang, Y Zhou, W Li, ... Nature communications 8 (1), 16026, 2017 | 206 | 2017 |
| Homeobox oncogene activation by pan-cancer DNA hypermethylation JS Su, YH Huang, XC Cui, X Wang, X Zhang, Y Lei, J Xu, X Lin, K Chen, ... Genome Biology, 2018 | 107 | 2018 |
| Large DNA methylation nadirs anchor chromatin loops maintaining hematopoietic stem cell identity X Zhang, M Jeong, X Huang, XQ Wang, X Wang, W Zhou, MS Shamim, ... Molecular cell 78 (3), 506-521. e6, 2020 | 69 | 2020 |
| Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer B Bissig-Choisat, C Kettlun-Leyton, XD Legras, B Zorman, M Barzi, ... Journal of hepatology 65 (2), 325-333, 2016 | 68 | 2016 |
| DNA methylation and de-methylation using hybrid site-targeting proteins Y Lei, YH Huang, MA Goodell Genome biology 19, 1-12, 2018 | 64 | 2018 |
| Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners JE Sandoval, YH Huang, A Muise, MA Goodell, NO Reich Journal of Biological Chemistry 294 (13), 4898-4910, 2019 | 62 | 2019 |
| Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor YH Huang, CW Chen, V Sundaramurthy, M Słabicki, D Hao, CJ Watson, ... Cancer discovery 12 (1), 220-235, 2022 | 33 | 2022 |
| Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome A Tovy, C Rosas, AS Gaikwad, G Medrano, L Zhang, JM Reyes, ... Haematologica 107 (4), 887, 2022 | 16 | 2022 |
| Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis A Tovy, JM Reyes, L Zhang, YH Huang, C Rosas, AC Daquinag, ... Elife 11, e72359, 2022 | 14 | 2022 |
| A nucleolus-predominant piggyBac transposase, NP-mPB, mediates elevated transposition efficiency in mammalian cells JB Hong, FJ Chou, AT Ku, HH Fan, TL Lee, YH Huang, TL Yang, IC Su, ... Plos one 9 (2), e89396, 2014 | 7 | 2014 |
| Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nat Commun 8: 16026 Y Lei, X Zhang, J Su, M Jeong, MC Gundry, YH Huang, Y Zhou, W Li, ... | 5 | 2017 |
| Nearly a Third of Clonal Hematopoiesis-Associated DNMT3A Mutations Reduce Protein Stability and May be Associated with Poorer Prognosis YH Huang, A Tovy, V Sundaramurthy, J Su, J Hsu, L He, A Guzman, ... Blood 132, 1315, 2018 | 2 | 2018 |
| Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nat Commun. 2017; 8: 16026 Y Lei, X Zhang, J Su, M Jeong, MC Gundry, YH Huang | 2 | |
| Clonal Competition: Cisplatin Treatment Drives Dominance of TP53-over Tet2-Mutant Stem Cell Clones K Wohlan, L Brunetti, JI Hsu, KA Matatall, RL Murdaugh, L Zhang, ... Blood 140 (Supplement 1), 8590-8591, 2022 | | 2022 |
| A nucleolus-predominant piggyBac transposase increases transposition efficiency in human cancer cells JB Hong, FJ Chou, AT Ku, HH Fan, TL Lee, YH Huang, IC Su, YT Chen Cancer Research 74 (19_Supplement), 3495-3495, 2014 | | 2014 |
Margaret GoodellBaylor College of MedicineVerified email at bcm.edu
