| Mapping the degradable kinome provides a resource for expedited degrader development KA Donovan, FM Ferguson, JW Bushman, NA Eleuteri, D Bhunia, SS Ryu, ... Cell 183 (6), 1714-1731. e10, 2020 | 170 | 2020 |
| Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 TB Faust, H Yoon, RP Nowak, KA Donovan, Z Li, Q Cai, NA Eleuteri, ... Nature chemical biology 16 (1), 7-14, 2020 | 156 | 2020 |
| Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations M de Wispelaere, G Du, KA Donovan, T Zhang, NA Eleuteri, JC Yuan, ... Nature communications 10 (1), 3468, 2019 | 146 | 2019 |
| Discovery of an AKT degrader with prolonged inhibition of downstream signaling I You, EC Erickson, KA Donovan, NA Eleuteri, ES Fischer, NS Gray, ... Cell chemical biology 27 (1), 66-73. e7, 2020 | 97 | 2020 |
| Development and characterization of a Wee1 kinase degrader Z Li, BJ Pinch, CM Olson, KA Donovan, RP Nowak, CE Mills, DA Scott, ... Cell chemical biology 27 (1), 57-65. e9, 2020 | 76 | 2020 |
| Acute pharmacological degradation of Helios destabilizes regulatory T cells ES Wang, AL Verano, RP Nowak, JC Yuan, KA Donovan, NA Eleuteri, ... Nature chemical biology 17 (6), 711-717, 2021 | 59 | 2021 |
| Chemo-proteomics exploration of HDAC degradability by small molecule degraders Y Xiong, KA Donovan, NA Eleuteri, N Kirmani, H Yue, A Razov, ... Cell chemical biology 28 (10), 1514-1527. e4, 2021 | 46 | 2021 |
| Exploring the target scope of KEAP1 E3 ligase-based PROTACs G Du, J Jiang, NJ Henning, N Safaee, E Koide, RP Nowak, KA Donovan, ... Cell chemical biology 29 (10), 1470-1481. e31, 2022 | 37 | 2022 |
| IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia BJ Aubrey, JA Cutler, W Bourgeois, KA Donovan, S Gu, C Hatton, ... Nature cancer 3 (5), 595-613, 2022 | 19 | 2022 |
| Structure-guided design of a “bump-and-hole” bromodomain-based degradation tag RP Nowak, Y Xiong, N Kirmani, J Kalabathula, KA Donovan, NA Eleuteri, ... Journal of Medicinal Chemistry 64 (15), 11637-11650, 2021 | 15 | 2021 |
| A protocol for rapid degradation of endogenous transcription factors in mammalian cells and identification of direct regulatory targets HM Layden, NA Eleuteri, SW Hiebert, KR Stengel STAR protocols 2 (2), 100530, 2021 | 9 | 2021 |
| Selective hdac6 degraders and methods of use thereof ES Fischer, Y Xiong, K Donovan, N Eleuteri US Patent App. 17/773,785, 2023 | | 2023 |
| Chemoproteomic Profiling Surveys the Degradable Proteome K Donovan, F Ferguson, Y Xiong, J Bushman, N Eleuteri, N Gray, ... Journal of Biological Chemistry 299 (3), S361, 2023 | | 2023 |
| Selective histone deacetylase (hdac) degraders and methods of use thereof ES Fischer, Y Xiong, K Donovan, N Eleuteri US Patent App. 17/774,002, 2022 | | 2022 |
| Selective dual histone deacetylase 6/8 (hdac6/8) degraders and methods of use thereof ES Fischer, Y Xiong, K Donovan, N Eleuteri US Patent App. 17/773,992, 2022 | | 2022 |
| Mapping the Degradable Kinome: A Resource for Expedited Degrader Development KA Donovan, FM Ferguson, JW Bushman, NA Eleuteri, D Bhunia, SS Ryu, ... American Society for Biochemistry and Molecular Biology 21 (8), 100302, 2022 | | 2022 |
Eric S FischerProfessor of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolVerified email at crystal.harvard.edu
