PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling VA Morais, D Haddad, K Craessaerts, PJ De Bock, J Swerts, S Vilain, ... Science 344 (6180), 203-207, 2014 | 364 | 2014 |
New insights into the complex role of mitochondria in Parkinson’s disease A Grünewald, KR Kumar, CM Sue Progress in neurobiology 177, 73-93, 2019 | 328 | 2019 |
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts … A Rakovic, K Shurkewitsch, P Seibler, A Grünewald, A Zanon, J Hagenah, ... Journal of Biological Chemistry 288 (4), 2223-2237, 2013 | 258 | 2013 |
Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts A Rakovic, A Grünewald, J Kottwitz, N Brüggemann, PP Pramstaller, ... PloS one 6 (3), e16746, 2011 | 258 | 2011 |
Mitochondrial DNA Depletion in Respiratory Chain–Deficient Parkinson Disease Neurons A Grünewald, KA Rygiel, PD Hepplewhite, CM Morris, M Picard, ... Annals of neurology 79 (3), 366-378, 2016 | 229 | 2016 |
Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness SB Wortmann, FM Vaz, T Gardeitchik, LELM Vissers, GH Renkema, ... Nature genetics 44 (7), 797-802, 2012 | 227 | 2012 |
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state S Smajić, CA Prada-Medina, Z Landoulsi, J Ghelfi, S Delcambre, ... Brain 145 (3), 964-978, 2022 | 208 | 2022 |
Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts A Grünewald, L Voges, A Rakovic, M Kasten, H Vandebona, ... PloS one 5 (9), e12962, 2010 | 187 | 2010 |
Genotype‐phenotype relations for the Parkinson's disease genes SNCA, LRRK2, VPS35: MDSGene systematic review J Trinh, FMJ Zeldenrust, J Huang, M Kasten, S Schaake, S Petkovic, ... Movement Disorders 33 (12), 1857-1870, 2018 | 158 | 2018 |
The contribution of microglia to neuroinflammation in Parkinson’s disease K Badanjak, S Fixemer, S Smajić, A Skupin, A Grünewald International Journal of Molecular Sciences 22 (9), 4676, 2021 | 157 | 2021 |
Mitochondria and Parkinson’s disease: clinical, molecular, and translational aspects M Borsche, SL Pereira, C Klein, A Grünewald Journal of Parkinson's disease 11 (1), 45-60, 2021 | 156 | 2021 |
Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit? K Hedrich, J Hagenah, A Djarmati, A Hiller, T Lohnau, K Lasek, ... Archives of neurology 63 (6), 833-838, 2006 | 152 | 2006 |
ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome A Grünewald, B Arns, P Seibler, A Rakovic, A Münchau, A Ramirez, ... Neurobiology of aging 33 (8), 1843. e1-1843. e7, 2012 | 148 | 2012 |
Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients A Rakovic, A Grünewald, P Seibler, A Ramirez, N Kock, S Orolicki, ... Human molecular genetics 19 (16), 3124-3137, 2010 | 145 | 2010 |
Myoclonus‐dystonia: significance of large SGCE deletions A Grünewald, A Djarmati, K Lohmann‐Hedrich, K Farrell, JA Zeller, ... Human mutation 29 (2), 331-332, 2008 | 136 | 2008 |
Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model D Alvarez-Fischer, C Noelker, F Vulinović, A Grünewald, C Chevarin, ... Plos one 8 (4), e61700, 2013 | 133 | 2013 |
A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis MC Rocha, JP Grady, A Grünewald, A Vincent, PF Dobson, RW Taylor, ... Scientific reports 5 (1), 15037, 2015 | 130 | 2015 |
Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology A Grünewald, ME Gegg, JW Taanman, RH King, N Kock, C Klein, ... Experimental neurology 219 (1), 266-273, 2009 | 126 | 2009 |
Bioenergetic consequences of PINK1 mutations in Parkinson disease AY Abramov, M Gegg, A Grunewald, NW Wood, C Klein, AHV Schapira PloS one 6 (10), e25622, 2011 | 123 | 2011 |
Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism M Borsche, IR König, S Delcambre, S Petrucci, A Balck, N Brüggemann, ... Brain 143 (10), 3041-3051, 2020 | 118 | 2020 |