Dos Sarbassov
Dos Sarbassov
Professor of Biology, Nazarbayev University
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Cited by
Cited by
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov, DA Guertin, SM Ali, DM Sabatini
Science 307 (5712), 1098-1101, 2005
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim, DD Sarbassov, SM Ali, JE King, RR Latek, ...
Cell 110 (2), 163-175, 2002
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov, SM Ali, DH Kim, DA Guertin, RR Latek, ...
Current biology 14 (14), 1296-1302, 2004
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov, SM Ali, S Sengupta, JH Sheen, PP Hsu, AF Bagley, ...
Molecular cell 22 (2), 159-168, 2006
Growing roles for the mTOR pathway
DD Sarbassov, SM Ali, DM Sabatini
Current opinion in cell biology 17 (6), 596-603, 2005
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
DH Kim, DD Sarbassov, SM Ali, RR Latek, KVP Guntur, ...
Molecular cell 11 (4), 895-904, 2003
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Z Zeng, DD Sarbassov, IJ Samudio, KWL Yee, MF Munsell, ...
Blood 109 (8), 3509-3512, 2007
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis
CH Chan, CF Li, WL Yang, Y Gao, SW Lee, Z Feng, HY Huang, KKC Tsai, ...
Cell 149 (5), 1098-1111, 2012
Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
DD Sarbassov, DM Sabatini
Journal of Biological Chemistry 280 (47), 39505-39509, 2005
FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse
KE Hentges, B Sirry, AC Gingeras, D Sarbassov, N Sonenberg, ...
Proceedings of the National Academy of Sciences 98 (24), 13796-13801, 2001
ER stress inhibits mTORC2 and Akt signaling through GSK-3β–mediated phosphorylation of Rictor
CH Chen, T Shaikenov, TR Peterson, R Aimbetov, AK Bissenbaev, ...
Science signaling 4 (161), ra10-ra10, 2011
ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies
JO Ishizawa, K Kojima, D Chachad, P Ruvolo, V Ruvolo, RO Jacamo, ...
Science signaling 9 (415), ra17-ra17, 2016
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers
R Zhao, SCJ Yeung, J Chen, T Iwakuma, CH Su, B Chen, C Qu, F Zhang, ...
The Journal of clinical investigation 121 (3), 851-865, 2011
FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT PathwayFoxOs Regulate Renal Tumor …
A Lin, H Piao, L Zhuang, DD Sarbassov, L Ma, B Gan
Cancer research 74 (6), 1682-1693, 2014
Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation
Y Liao, Y Wei, X Zhou, JY Yang, C Dai, YJ Chen, NK Agarwal, ...
Oncogene 28 (26), 2436-2445, 2009
Extracellular signal-regulated kinase-1 and-2 respond differently to mitogenic and differentiative signaling pathways in myoblasts
DD Sarbassov, LG Jones, CA Peterson
Molecular Endocrinology 11 (13), 2038-2047, 1997
Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2The Rapamycin-Dependent Rictor Phosphorylation
D Boulbes, CH Chen, T Shaikenov, NK Agarwal, TR Peterson, TA Addona, ...
Molecular Cancer Research 8 (6), 896-906, 2010
Endoplasmic reticulum is a main localization site of mTORC2
DR Boulbés, T Shaiken, DD Sarbassov
Biochemical and biophysical research communications 413 (1), 46-52, 2011
A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis
AH Rezaeian, CF Li, CY Wu, X Zhang, J Delacerda, MJ You, F Han, Z Cai, ...
Nature cell biology 19 (1), 38-51, 2017
Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast CancersHER2-Mediated Tumorigenesis Requires mTORC2
M Morrison Joly, DJ Hicks, B Jones, V Sanchez, MV Estrada, C Young, ...
Cancer research 76 (16), 4752-4764, 2016
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