Gary Mirams
Gary Mirams
Other namesGary Richard Mirams
Centre for Mathematical Medicine & Biology, University of Nottingham
Verified email at - Homepage
Cited by
Cited by
Chaste: an open source C++ library for computational physiology and biology
GR Mirams, CJ Arthurs, MO Bernabeu, R Bordas, J Cooper, A Corrias, ...
PLoS computational biology 9 (3), e1002970, 2013
Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk
GR Mirams, Y Cui, A Sher, M Fink, J Cooper, BM Heath, NC McMahon, ...
Cardiovascular research 91 (1), 53, 2011
Chaste: a test-driven approach to software development for biological modelling
J Pitt-Francis, P Pathmanathan, MO Bernabeu, R Bordas, J Cooper, ...
Computer Physics Communications 180 (12), 2452-2471, 2009
An integrative computational model for intestinal tissue renewal
IMM Van Leeuwen, GR Mirams, A Walter, A Fletcher, P Murray, J Osborne, ...
Cell proliferation 42 (5), 617-636, 2009
Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current I f: Novel electrophysiological insights and therapeutic potential
RA Capel, N Herring, M Kalla, A Yavari, GR Mirams, G Douglas, G Bub, ...
Heart Rhythm 12 (10), 2186-2194, 2015
Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?
RH Johnstone, ETY Chang, R Bardenet, TP De Boer, DJ Gavaghan, ...
Journal of molecular and cellular cardiology 96, 49-62, 2016
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG
MKB Jonsson, MA Vos, GR Mirams, G Duker, P Sartipy, TP de Boer, ...
Journal of Molecular and Cellular Cardiology 52 (5), 998-1008, 2012
A hybrid approach to multi-scale modelling of cancer
JM Osborne, A Walter, SK Kershaw, GR Mirams, AG Fletcher, ...
Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2010
Uncertainty and variability in computational and mathematical models of cardiac physiology
GR Mirams, P Pathmanathan, RA Gray, P Challenor, RH Clayton
The Journal of physiology 594 (23), 6833-6847, 2016
A computational study of discrete mechanical tissue models
P Pathmanathan, J Cooper, A Fletcher, G Mirams, P Murray, J Osborne, ...
Physical biology 6 (3), 036001, 2009
Assessment of an in silico mechanistic model for proarrhythmia risk prediction under the CiPA initiative
Z Li, WW Wu, J Sheng, PN Tran, M Wu, A Ranolph, RH Johnstone, ...
Clinical Pharmacology & Therapeutics, 2018
Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials
N Zemzemi, MO Bernabeu, J Saiz, J Cooper, P Pathmanathan, ...
British Journal of Pharmacology 168 (3), 718-733, 2012
Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing
GR Mirams, MR Davies, Y Cui, P Kohl, D Noble
British Journal of Pharmacology 167 (5), 932-945, 2012
Systems Toxicology: Real World Applications and Opportunities
T Hartung, RE FitzGerald, P Jennings, GR Mirams, MC Peitsch, ...
Chemical Research in Toxicology 30 (4), 870, 2017
Prediction of Thorough QT study results using action potential simulations based on ion channel screens
GR Mirams, MR Davies, SJ Brough, MH Bridgland-Taylor, Y Cui, ...
Journal of pharmacological and toxicological methods 70 (3), 246-254, 2014
Calibration of ionic and cellular cardiac electrophysiology models
DG Whittaker, M Clerx, CL Lei, DJ Christini, GR Mirams
Wiley Interdisciplinary Reviews: Systems Biology and Medicine 12 (4), e1482, 2020
Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
RC Elkins, MR Davies, SJ Brough, DJ Gavaghan, Y Cui, N Abi-Gerges, ...
Journal of pharmacological and toxicological methods 68 (1), 112-122, 2013
mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study
J Walmsley, JF Rodriguez, GR Mirams, K Burrage, IR Efimov, ...
PloS one 8 (2), e56359, 2013
Uncertainty quantification reveals the importance of data variability and experimental design considerations for in silico proarrhythmia risk assessment
KC Chang, S Dutta, GR Mirams, KA Beattie, J Sheng, PN Tran, M Wu, ...
Frontiers in physiology 8, 917, 2017
Recent developments in using mechanistic cardiac modelling for drug safety evaluation
MR Davies, K Wang, GR Mirams, A Caruso, D Noble, A Walz, T Lavé, ...
Drug discovery today 21 (6), 924-938, 2016
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