| Chaste: an open source C++ library for computational physiology and biology GR Mirams, CJ Arthurs, MO Bernabeu, R Bordas, J Cooper, A Corrias, ... PLoS computational biology 9 (3), e1002970, 2013 | 441 | 2013 |
| Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk GR Mirams, Y Cui, A Sher, M Fink, J Cooper, BM Heath, NC McMahon, ... Cardiovascular research 91 (1), 53, 2011 | 304 | 2011 |
| Chaste: a test-driven approach to software development for biological modelling J Pitt-Francis, P Pathmanathan, MO Bernabeu, R Bordas, J Cooper, ... Computer Physics Communications 180 (12), 2452-2471, 2009 | 284 | 2009 |
| An integrative computational model for intestinal tissue renewal IMM Van Leeuwen, GR Mirams, A Walter, A Fletcher, P Murray, J Osborne, ... Cell proliferation 42 (5), 617-636, 2009 | 169 | 2009 |
| Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG MKB Jonsson, MA Vos, GR Mirams, G Duker, P Sartipy, TP de Boer, ... Journal of Molecular and Cellular Cardiology 52 (5), 998-1008, 2012 | 150 | 2012 |
| Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current I f: Novel electrophysiological insights and therapeutic potential RA Capel, N Herring, M Kalla, A Yavari, GR Mirams, G Douglas, G Bub, ... Heart Rhythm 12 (10), 2186-2194, 2015 | 148 | 2015 |
| Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models? RH Johnstone, ETY Chang, R Bardenet, TP De Boer, DJ Gavaghan, ... Journal of molecular and cellular cardiology 96, 49-62, 2016 | 142 | 2016 |
| A hybrid approach to multi-scale modelling of cancer JM Osborne, A Walter, SK Kershaw, GR Mirams, AG Fletcher, ... Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2010 | 141 | 2010 |
| A computational study of discrete mechanical tissue models P Pathmanathan, J Cooper, A Fletcher, G Mirams, P Murray, J Osborne, ... Physical biology 6 (3), 036001, 2009 | 133 | 2009 |
| Uncertainty and variability in computational and mathematical models of cardiac physiology GR Mirams, P Pathmanathan, RA Gray, P Challenor, RH Clayton The Journal of physiology 594 (23), 6833-6847, 2016 | 128 | 2016 |
| Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials N Zemzemi, MO Bernabeu, J Saiz, J Cooper, P Pathmanathan, ... British Journal of Pharmacology 168 (3), 718-733, 2012 | 120 | 2012 |
| Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing GR Mirams, MR Davies, Y Cui, P Kohl, D Noble British Journal of Pharmacology 167 (5), 932-945, 2012 | 106 | 2012 |
| Assessment of an in silico mechanistic model for proarrhythmia risk prediction under the CiPA initiative Z Li, WW Wu, J Sheng, PN Tran, M Wu, A Ranolph, RH Johnstone, ... Clinical Pharmacology & Therapeutics, 2018 | 102 | 2018 |
| Prediction of Thorough QT study results using action potential simulations based on ion channel screens GR Mirams, MR Davies, SJ Brough, MH Bridgland-Taylor, Y Cui, ... Journal of pharmacological and toxicological methods 70 (3), 246-254, 2014 | 91 | 2014 |
| Systems Toxicology: Real World Applications and Opportunities T Hartung, RE FitzGerald, P Jennings, GR Mirams, MC Peitsch, ... Chemical Research in Toxicology 30 (4), 870, 2017 | 88 | 2017 |
| mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study J Walmsley, JF Rodriguez, GR Mirams, K Burrage, IR Efimov, ... PloS one 8 (2), e56359, 2013 | 79 | 2013 |
| Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment RC Elkins, MR Davies, SJ Brough, DJ Gavaghan, Y Cui, N Abi-Gerges, ... Journal of pharmacological and toxicological methods 68 (1), 112-122, 2013 | 78 | 2013 |
| A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt GR Mirams, AG Fletcher, PK Maini, HM Byrne Journal of Theoretical Biology 312 (7), 143-156, 2012 | 73 | 2012 |
| Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing TA Quinn, S Granite, MA Allessie, C Antzelevitch, C Bollensdorff, G Bub, ... Progress in biophysics and molecular biology 107 (1), 4-10, 2011 | 72 | 2011 |
| Recent developments in using mechanistic cardiac modelling for drug safety evaluation MR Davies, K Wang, GR Mirams, A Caruso, D Noble, A Walz, T Lavé, ... Drug discovery today 21 (6), 924-938, 2016 | 67 | 2016 |
David GavaghanProfessor of Computational Biology, University of OxfordVerified email at cs.ox.ac.uk
