Jonathan W. Wojtkowiak
Jonathan W. Wojtkowiak
Blueprint Medicines; Previous Moffitt Cancer Center
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Cited by
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Acidity generated by the tumor microenvironment drives local invasion
V Estrella, T Chen, M Lloyd, J Wojtkowiak, HH Cornnell, ...
Cancer research 73 (5), 1524-1535, 2013
pH sensing and regulation in cancer
M Damaghi, JW Wojtkowiak, RJ Gillies
Frontiers in physiology 4, 370, 2013
Drug resistance and cellular adaptation to tumor acidic pH microenvironment
JW Wojtkowiak, D Verduzco, KJ Schramm, RJ Gillies
Molecular pharmaceutics 8 (6), 2032-2038, 2011
Neutralization of tumor acidity improves antitumor responses to immunotherapy
S Pilon-Thomas, KN Kodumudi, AE El-Kenawi, S Russell, AM Weber, ...
Cancer research 76 (6), 1381-1390, 2016
Imaging pH and metastasis
AI Hashim, X Zhang, JW Wojtkowiak, GV Martinez, RJ Gillies
NMR in biomedicine 24 (6), 582-591, 2011
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments
JW Wojtkowiak, JM Rothberg, V Kumar, KJ Schramm, E Haller, ...
Cancer research 72 (16), 3938-3947, 2012
Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane
M Damaghi, NK Tafreshi, MC Lloyd, R Sprung, V Estrella, JW Wojtkowiak, ...
Nature communications 6 (1), 8752, 2015
A physical sciences network characterization of non-tumorigenic and metastatic cells
Scientific reports 3 (1), 1449, 2013
Targeting the metabolic microenvironment of tumors
KM Bailey, JW Wojtkowiak, AI Hashim, RJ Gillies
Advances in pharmacology 65, 63-107, 2012
Application of evolutionary principles to cancer therapy
PM Enriquez-Navas, JW Wojtkowiak, RA Gatenby
Cancer research 75 (22), 4675-4680, 2015
Defining cancer subpopulations by adaptive strategies rather than molecular properties provides novel insights into intratumoral evolution
A Ibrahim-Hashim, M Robertson-Tessi, PM Enriquez-Navas, M Damaghi, ...
Cancer research 77 (9), 2242-2254, 2017
Acid-mediated tumor proteolysis: contribution of cysteine cathepsins
JM Rothberg, KM Bailey, JW Wojtkowiak, Y Ben-Nun, M Bogyo, E Weber, ...
Neoplasia 15 (10), 1125-IN9, 2013
The damaging effect of passenger mutations on cancer progression
CD McFarland, JA Yaglom, JW Wojtkowiak, JG Scott, DL Morse, ...
Cancer research 77 (18), 4763-4772, 2017
Metabolic Profiling of healthy and cancerous tissues in 2D and 3D
S Russell, J Wojtkowiak, A Neilson, RJ Gillies
Scientific reports 7 (1), 15285, 2017
Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302
JW Wojtkowiak, HC Cornnell, S Matsumoto, K Saito, Y Takakusagi, ...
Cancer & metabolism 3 (1), 1-13, 2015
Free base lysine increases survival and reduces metastasis in prostate cancer model
A Ibrahim-Hashim, JW Wojtkowiak, MLC Ribeiro, V Estrella, KM Bailey, ...
Journal of cancer science & therapy, 2011
A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells
KM Sane, M Mynderse, DT LaLonde, IS Dean, JW Wojtkowiak, F Fouad, ...
Journal of Pharmacology and Experimental Therapeutics 333 (1), 23-33, 2010
Molecular targets for emerging anti-tumor therapies for neurofibromatosis type 1
JT Dilworth, JM Kraniak, JW Wojtkowiak, RA Gibbs, RF Borch, MA Tainsky, ...
Biochemical pharmacology 72 (11), 1485-1492, 2006
Induction of apoptosis in neurofibromatosis type 1 malignant peripheral nerve sheath tumor cell lines by a combination of novel farnesyl transferase inhibitors and lovastatin
JW Wojtkowiak, F Fouad, DT LaLonde, MD Kleinman, RA Gibbs, ...
Journal of Pharmacology and Experimental Therapeutics 326 (1), 1-11, 2008
Autophagy on acid
JW Wojtkowiak, RJ Gillies
Autophagy 8 (11), 1688-1689, 2012
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