| How nematode sperm crawl D Bottino, A Mogilner, T Roberts, M Stewart, G Oster Journal of cell science 115 (2), 367-384, 2002 | 263 | 2002 |
| Modeling viscoelastic networks and cell deformation in the context of the immersed boundary method DC Bottino Journal of Computational Physics 147 (1), 86-113, 1998 | 103 | 1998 |
| A computational model of ameboid deformation and locomotion DC Bottino, LJ Fauci European Biophysics Journal 27, 532-539, 1998 | 95 | 1998 |
| Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart D Bottino, RC Penland, A Stamps, M Traebert, B Dumotier, A Georgieva, ... Progress in biophysics and molecular biology 90 (1-3), 414-443, 2006 | 79 | 2006 |
| Progress and opportunities to advance clinical cancer therapeutics using tumor dynamic models R Bruno, D Bottino, DP De Alwis, AT Fojo, J Guedj, C Liu, KR Swanson, ... Clinical Cancer Research 26 (8), 1787-1795, 2020 | 59 | 2020 |
| Bcr–abl transcript dynamics support the hypothesis that leukemic stem cells are reduced during imatinib treatment AM Stein, D Bottino, V Modur, S Branford, J Kaeda, JM Goldman, ... Clinical Cancer Research 17 (21), 6812-6821, 2011 | 54 | 2011 |
| Quantitative systems pharmacology approaches for immuno‐oncology: adding virtual patients to the development paradigm V Chelliah, G Lazarou, S Bhatnagar, JP Gibbs, M Nijsen, A Ray, B Stoll, ... Clinical Pharmacology & Therapeutics 109 (3), 605-618, 2021 | 51 | 2021 |
| Biological modeling utilizing image data G Lett, D Bottino US Patent App. 10/095,175, 2003 | 49 | 2003 |
| A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers UN Lassen, D Meulendijks, LL Siu, V Karanikas, M Mau-Sorensen, ... Clinical Cancer Research 21 (2), 258-266, 2015 | 38 | 2015 |
| A minimal model of locomotion applied to the steady gliding movement of fish keratocyte cells A Mogilner, E Marland, D Bottino Mathematical Models for Biological Pattern Formation, 269-293, 2001 | 34 | 2001 |
| A systems pharmacology model for drug delivery to solid tumors by antibody-drug conjugates: implications for bystander effects JK Burton, D Bottino, TW Secomb The AAPS journal 22 (1), 12, 2019 | 29 | 2019 |
| P1. 13-44 safety, PK, and preliminary antitumor activity of the oral EGFR/HER2 exon 20 inhibitor TAK-788 in NSCLC J Neal, R Doebele, G Riely, A Spira, L Horn, Z Piotrowska, D Costa, ... Journal of Thoracic Oncology 13 (10), S599, 2018 | 27 | 2018 |
| Dose optimization for anticancer drug combinations: maximizing therapeutic index via clinical exposure-toxicity/preclinical exposure-efficacy modeling DC Bottino, M Patel, E Kadakia, J Zhou, C Patel, R Neuwirth, N Iartchouk, ... Clinical Cancer Research 25 (22), 6633-6643, 2019 | 24 | 2019 |
| Exposure and tumor Fn14 expression as determinants of pharmacodynamics of the anti-TWEAK monoclonal antibody RG7212 in patients with Fn14-positive solid tumors D Meulendijks, UN Lassen, LL Siu, ADR Huitema, V Karanikas, ... Clinical Cancer Research 22 (4), 858-867, 2016 | 18 | 2016 |
| Nonuniform sampling for global optimization of kinetic rate constants in biological pathways SH Kleinstein, D Bottino, A Georgieva, R Sarangapani, GS Lett Proceedings of the 2006 Winter Simulation Conference, 1611-1616, 2006 | 17 | 2006 |
| Computer simulations of mechanochemical coupling in a deforming domain: applications to cell motion DC Bottino Mathematical models for biological pattern formation, 295-314, 2001 | 15 | 2001 |
| Mathematical modeling and simulation to investigate the CNS transport characteristics of nanoemulsion-based drug delivery following intranasal administration E Kadakia, D Bottino, M Amiji Pharmaceutical Research 36, 1-17, 2019 | 13 | 2019 |
| Directional inconsistency between Response Evaluation Criteria in Solid Tumors (RECIST) time to progression and response speed and depth K Johnson, A Gomez, J Burton, D White, A Chakravarty, A Schmid, ... European Journal of Cancer 109, 196-203, 2019 | 12 | 2019 |
| A comprehensive regulatory and industry review of modeling and simulation practices in oncology clinical drug development A Ruiz-Garcia, P Baverel, D Bottino, M Dolton, Y Feng, I González-García, ... Journal of Pharmacokinetics and Pharmacodynamics 50 (3), 147-172, 2023 | 10 | 2023 |
| Transforming translation through quantitative pharmacology for high‐impact decision making in drug discovery and development N Gupta, D Bottino, USH Simonsson, CJ Musante, T Bueters, TR Rieger, ... Clinical Pharmacology & Therapeutics 107 (6), 1285-1289, 2020 | 10 | 2020 |
