Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer L Xue, X Rovira, P Scholler, H Zhao, J Liu, JP Pin, P Rondard Nature chemical biology 11 (2), 134-140, 2015 | 195 | 2015 |
An allosteric modulator to control endogenous G protein-coupled receptors with light S Pittolo, X Gómez-Santacana, K Eckelt, X Rovira, J Dalton, C Goudet, ... Nature chemical biology 10 (10), 813-815, 2014 | 169 | 2014 |
The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways X Rovira, JP Pin, J Giraldo Trends in pharmacological sciences 31 (1), 15-21, 2010 | 84 | 2010 |
OptoGluNAM4. 1, a photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activity X Rovira, A Trapero, S Pittolo, C Zussy, A Faucherre, C Jopling, J Giraldo, ... Cell chemical biology 23 (8), 929-934, 2016 | 79 | 2016 |
Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells D Moreno Delgado, TC Møller, J Ster, J Giraldo, D Maurel, X Rovira, ... Elife 6, e25233, 2017 | 78 | 2017 |
Illuminating phenylazopyridines to photoswitch metabotropic glutamate receptors: from the flask to the animals X Gómez-Santacana, S Pittolo, X Rovira, M Lopez, C Zussy, JAR Dalton, ... ACS central science 3 (1), 81-91, 2017 | 75 | 2017 |
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation P Scholler, D Nevoltris, D de Bundel, S Bossi, D Moreno-Delgado, ... Nature Communications 8 (1), 1967, 2017 | 71 | 2017 |
Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors X Rovira, F Malhaire, P Scholler, J Rodrigo, P Gonzalez‐Bulnes, ... The FASEB Journal 29 (1), 116-130, 2015 | 64 | 2015 |
Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4 C Zussy, X Gómez-Santacana, X Rovira, D De Bundel, S Ferrazzo, ... Molecular psychiatry 23 (3), 509-520, 2018 | 63 | 2018 |
Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer J Liu, Z Zhang, D Moreno-Delgado, JAR Dalton, X Rovira, A Trapero, ... Elife 6, e26985, 2017 | 58 | 2017 |
Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator J Font, M Lopez-Cano, S Notartomaso, P Scarselli, P Di Pietro, ... Elife 6, e23545, 2017 | 57 | 2017 |
Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer L Xue, Q Sun, H Zhao, X Rovira, S Gai, Q He, JP Pin, J Liu, P Rondard Nature communications 10 (1), 2765, 2019 | 54 | 2019 |
The catalytic power of enzymes: Conformational selection or transition state stabilization? J Giraldo, D Roche, X Rovira, J Serra FEBS letters 580 (9), 2170-2177, 2006 | 46 | 2006 |
Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice S Marcos, C Monnier, X Rovira, C Fouveaut, N Pitteloud, F Ango, C Dodé, ... Human molecular genetics 26 (11), 2006-2017, 2017 | 43 | 2017 |
Allosteric modulation of metabotropic glutamate receptors by chloride ions AS Tora, X Rovira, I Dione, HO Bertrand, I Brabet, Y De Koninck, N Doyon, ... The FASEB Journal 29 (10), 4174-4188, 2015 | 40 | 2015 |
FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor N Lecat-Guillet, C Monnier, X Rovira, J Kniazeff, L Lamarque, JM Zwier, ... Cell Chemical Biology 24 (3), 360-370, 2017 | 39 | 2017 |
Assessing receptor affinity for inverse agonists: Schild and Cheng-Prusoff methods revisited J Giraldo, J Serra, D Roche, X Rovira Current drug targets 8 (1), 197-202, 2007 | 31 | 2007 |
Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3 AS Tora, X Rovira, AM Cao, A Cabayé, L Olofsson, F Malhaire, P Scholler, ... Neuropharmacology 140, 275-286, 2018 | 29 | 2018 |
Modeling the binding and function of metabotropic glutamate receptors X Rovira, D Roche, J Serra, J Kniazeff, JP Pin, J Giraldo Journal of Pharmacology and Experimental Therapeutics 325 (2), 443-456, 2008 | 27 | 2008 |
Photoswitchable Antagonists for a Precise Spatiotemporal Control of β2-Adrenoceptors A Duran-Corbera, J Catena, M Otero-Viñas, A Llebaria, X Rovira Journal of Medicinal Chemistry 63 (15), 8458-8470, 2020 | 25 | 2020 |