A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ... Nature communications 8 (1), 1-8, 2017 | 94 | 2017 |
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering DA Keedy, ZB Hill, JT Biel, E Kang, TJ Rettenmaier, J Brandao-Neto, ... Elife 7, e36307, 2018 | 48 | 2018 |
Gentle, fast and effective crystal soaking by acoustic dispensing PM Collins, JT Ng, R Talon, K Nekrosiute, T Krojer, A Douangamath, ... Acta Crystallographica Section D: Structural Biology 73 (3), 246-255, 2017 | 42 | 2017 |
The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination T Krojer, R Talon, N Pearce, P Collins, A Douangamath, J Brandao-Neto, ... Acta Crystallographica Section D: Structural Biology 73 (3), 267-278, 2017 | 38 | 2017 |
Proper modelling of ligand binding requires an ensemble of bound and unbound states NM Pearce, T Krojer, F Von Delft Acta Crystallographica Section D: Structural Biology 73 (3), 256-266, 2017 | 27 | 2017 |
Insights into enhanced complement activation by structures of properdin and its complex with the C-terminal domain of C3b RM van den Bos, NM Pearce, J Granneman, THC Brondijk, P Gros Frontiers in immunology 10, 2097, 2019 | 14 | 2019 |
Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites NM Pearce, AR Bradley, T Krojer, BD Marsden, CM Deane, F Von Delft Structural Dynamics 4 (3), 032104, 2017 | 11 | 2017 |
Ten simple rules for surviving an interdisciplinary PhD S Demharter, N Pearce, K Beattie, I Frost, J Leem, A Martin, ... PLoS computational biology 13 (5), e1005512, 2017 | 4 | 2017 |
Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F W Oosterheert, KT Xenaki, V Neviani, W Pos, S Doulkeridou, ... Life science alliance 3 (11), 2020 | 1 | 2020 |
Rubies in the Smoke: Multi-dataset methods for the extraction of weak signal in X-ray crystallography N Pearce, S Kelm, J Shi, C Deane, F von Delft 66th Annual Meeting, 2016 | | 2016 |
PANDDAs: multi-dataset methods for finding hits from fragment screening by X-ray crystallography NM Pearce, S Kelm, J Shi, CM Deane, F von Delft ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 71, S258-S258, 2015 | | 2015 |