|Naive CD4+ T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude|
JJ Moon, HH Chu, M Pepper, SJ McSorley, SC Jameson, RM Kedl, ...
Immunity 27 (2), 203-213, 2007
|Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells|
JM Curtsinger, CS Schmidt, A Mondino, DC Lins, RM Kedl, MK Jenkins, ...
The Journal of Immunology 162 (6), 3256-3262, 1999
|Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8|
KB Gorden, KS Gorski, SJ Gibson, RM Kedl, WC Kieper, X Qiu, MA Tomai, ...
The Journal of Immunology 174 (3), 1259-1268, 2005
|T cell responses: naive to memory and everything in between|
ND Pennock, JT White, EW Cross, EE Cheney, BA Tamburini, RM Kedl
Advances in physiology education 37 (4), 273-283, 2013
|T cells compete for access to antigen-bearing antigen-presenting cells|
RM Kedl, WA Rees, DA Hildeman, B Schaefer, T Mitchell, J Kappler, ...
The Journal of experimental medicine 192 (8), 1105-1114, 2000
|Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod|
SJ Gibson, JM Lindh, TR Riter, RM Gleason, LM Rogers, AE Fuller, ...
Cellular immunology 218 (1-2), 74-86, 2002
|Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell Expansion with Variable Dependence on Type I IFN|
CL Ahonen, CL Doxsee, SM McGurran, TR Riter, WF Wade, RJ Barth, ...
The Journal of experimental medicine 199 (6), 775-784, 2004
|Observation of antigen-dependent CD8+ T-cell/dendritic cell interactions in vivo|
BC Schaefer, ML Schaefer, JW Kappler, P Marrack, RM Kedl
Cellular immunology 214 (2), 110-122, 2001
|The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion|
C Haluszczak, AD Akue, SE Hamilton, LDS Johnson, L Pujanauski, ...
Journal of Experimental Medicine 206 (2), 435-448, 2009
|HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates|
U Wille-Reece, BJ Flynn, K Loré, RA Koup, RM Kedl, JJ Mattapallil, ...
Proceedings of the National Academy of Sciences 102 (42), 15190-15194, 2005
|Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates|
U Wille-Reece, BJ Flynn, K Loré, RA Koup, AP Miles, A Saul, RM Kedl, ...
The Journal of experimental medicine 203 (5), 1249-1258, 2006
|Mechanism of T cell tolerance induction by murine hepatic Kupffer cells|
Q You, L Cheng, RM Kedl, C Ju
Hepatology 48 (3), 978-990, 2008
|CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen|
AN Desch, GJ Randolph, K Murphy, EL Gautier, RM Kedl, MH Lahoud, ...
Journal of Experimental Medicine 208 (9), 1789-1797, 2011
|An inverse relationship between T cell receptor affinity and antigen dose during CD4+ T cell responses in vivo and in vitro|
W Rees, J Bender, TK Teague, RM Kedl, F Crawford, P Marrack, ...
Proceedings of the National Academy of Sciences 96 (17), 9781-9786, 1999
|Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes|
K Zaks, M Jordan, A Guth, K Sellins, R Kedl, A Izzo, C Bosio, S Dow
The Journal of Immunology 176 (12), 7335-7345, 2006
|Immunological adjuvants promote activated T cell survival via induction of Bcl-3|
TC Mitchell, D Hildeman, RM Kedl, TK Teague, BC Schaefer, J White, ...
Nature immunology 2 (5), 397-402, 2001
|T cells down-modulate peptide-MHC complexes on APCs in vivo|
RM Kedl, BC Schaefer, JW Kappler, P Marrack
Nature immunology 3 (1), 27-32, 2002
|Activation changes the spectrum but not the diversity of genes expressed by T cells|
TK Teague, D Hildeman, RM Kedl, T Mitchell, W Rees, BC Schaefer, ...
Proceedings of the National Academy of Sciences 96 (22), 12691-12696, 1999
|Epitope dominance, competition and T cell affinity maturation|
RM Kedl, JW Kappler, P Marrack
Current opinion in immunology 15 (1), 120-127, 2003
|Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity|
JR Cubillos-Ruiz, X Engle, UK Scarlett, D Martinez, A Barber, R Elgueta, ...
The Journal of clinical investigation 119 (8), 2231-2244, 2009