|The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase|
T Gerken, CA Girard, YCL Tung, CJ Webby, V Saudek, KS Hewitson, ...
Science 318 (5855), 1469-1472, 2007
|The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases|
R Chowdhury, KK Yeoh, YM Tian, L Hillringhaus, EA Bagg, NR Rose, ...
EMBO reports 12 (5), 463-469, 2011
|Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins|
IJ Clifton, MA McDonough, D Ehrismann, NJ Kershaw, N Granatino, ...
Journal of inorganic biochemistry 100 (4), 644-669, 2006
|Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)|
MA McDonough, V Li, E Flashman, R Chowdhury, C Mohr, BMR Liénard, ...
Proceedings of the National Academy of Sciences 103 (26), 9814-9819, 2006
|Inhibition of 2-oxoglutarate dependent oxygenases|
NR Rose, MA McDonough, ONF King, A Kawamura, CJ Schofield
Chemical Society reviews 40 (8), 4364-4397, 2011
|Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity|
SS Ng, KL Kavanagh, MA McDonough, D Butler, ES Pilka, BMR Lienard, ...
Nature 448 (7149), 87-91, 2007
|Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)|
ME Cockman, DE Lancaster, IP Stolze, KS Hewitson, MA McDonough, ...
Proceedings of the National Academy of Sciences 103 (40), 14767-14772, 2006
|Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α|
PJ Pollard, C Loenarz, DR Mole, MA McDonough, JM Gleadle, ...
Biochemical Journal 416 (3), 387-394, 2008
|Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor|
ML Coleman, MA McDonough, KS Hewitson, C Coles, J Mecinović, ...
Journal of Biological Chemistry 282 (33), 24027-24038, 2007
|Structural studies on human 2-oxoglutarate dependent oxygenases|
MA McDonough, C Loenarz, R Chowdhury, IJ Clifton, CJ Schofield
Current opinion in structural biology 20 (6), 659-672, 2010
|Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates|
KS Hewitson, BMR Liénard, MA McDonough, IJ Clifton, D Butler, ...
Journal of Biological Chemistry 282 (5), 3293-3301, 2007
|Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases|
NR Rose, SS Ng, J Mecinovic, BMR Liénard, SH Bello, Z Sun, ...
Journal of medicinal chemistry 51 (22), 7053-7056, 2008
|Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases|
R Chowdhury, MA McDonough, J Mecinović, C Loenarz, E Flashman, ...
Structure 17 (7), 981-989, 2009
|Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches|
NR Rose, ECY Woon, GL Kingham, ONF King, J Mecinovic, IJ Clifton, ...
Journal of medicinal chemistry 53 (4), 1810-1818, 2010
|Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates|
J Brem, R Cain, S Cahill, MA McDonough, IJ Clifton, ...
Nature communications 7 (1), 1-8, 2016
|The enzymes of β-lactam biosynthesis|
RB Hamed, JR Gomez-Castellanos, L Henry, C Ducho, MA McDonough, ...
Natural product reports 30 (1), 21-107, 2013
|Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases|
WS Aik, MA McDonough, A Thalhammer, R Chowdhury, CJ Schofield
Current opinion in structural biology 22 (6), 691-700, 2012
|Selective inhibition of factor inhibiting hypoxia-inducible factor|
MA McDonough, LA McNeill, M Tilliet, CA Papamicaël, QY Chen, ...
Journal of the American Chemical Society 127 (21), 7680-7681, 2005
|A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis|
W Lee, MA McDonough, LP Kotra, ZH Li, NR Silvaggi, Y Takeda, JA Kelly, ...
Proceedings of the National Academy of Sciences 98 (4), 1427-1431, 2001
|5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation|
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical science 4 (8), 3110-3117, 2013