| The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of α2δ subunits is key to trafficking voltage-gated Ca2+ channels C Canti, M Nieto-Rostro, I Foucault, F Heblich, J Wratten, MW Richards, ... Proceedings of the National Academy of Sciences 102 (32), 11230-11235, 2005 | 279 | 2005 |
| Differential protein stability and clinical responses ofEML4-ALK fusion variants to various ALK inhibitors in advancedALK-rearranged non-small cell lung cancer CG Woo, S Seo, SW Kim, SJ Jang, KS Park, JY Song, B Lee, ... Annals of Oncology 28 (4), 791-797, 2017 | 202 | 2017 |
| Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors MW Richards, SG Burgess, E Poon, A Carstensen, M Eilers, L Chesler, ... Proceedings of the National Academy of Sciences 113 (48), 13726-13731, 2016 | 176 | 2016 |
| Ca2+ channel β-subunits: structural insights AID our understanding MW Richards, AJ Butcher, AC Dolphin Trends in pharmacological sciences 25 (12), 626-632, 2004 | 154 | 2004 |
| Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs R Bayliss, J Choi, DA Fennell, AM Fry, MW Richards Cellular and molecular life sciences 73, 1209-1224, 2016 | 120 | 2016 |
| Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design CA Dodson, M Kosmopoulou, MW Richards, B Atrash, V Bavetsias, ... Biochemical journal 427 (1), 19-28, 2010 | 110 | 2010 |
| Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain MW Richards, EWP Law, LVP Rennalls, S Busacca, L O’Regan, AM Fry, ... Proceedings of the National Academy of Sciences 111 (14), 5195-5200, 2014 | 105 | 2014 |
| Coordination of adjacent domains mediates TACC3–ch-TOG–clathrin assembly and mitotic spindle binding FE Hood, SJ Williams, SG Burgess, MW Richards, D Roth, A Straube, ... Journal of Cell Biology 202 (3), 463-478, 2013 | 105 | 2013 |
| An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9 MW Richards, L O'Regan, C Mas-Droux, JMY Blot, J Cheung, S Hoelder, ... Molecular cell 36 (4), 560-570, 2009 | 105 | 2009 |
| Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain MW Richards, L O'Regan, D Roth, JM Montgomery, A Straube, AM Fry, ... Biochemical Journal 467 (3), 529-536, 2015 | 84 | 2015 |
| Structural basis of poly (ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR) J Oberoi, MW Richards, S Crumpler, N Brown, J Blagg, R Bayliss Journal of Biological Chemistry 285 (50), 39348-39358, 2010 | 80 | 2010 |
| Molecular mechanisms of human IRE1 activation through dimerization and ligand binding A Joshi, Y Newbatt, PC McAndrew, M Stubbs, R Burke, MW Richards, ... Oncotarget 6 (15), 13019, 2015 | 65 | 2015 |
| Insights into the conformational variability and regulation of human Nek2 kinase I Westwood, DM Cheary, JE Baxter, MW Richards, RLM van Montfort, ... Journal of molecular biology 386 (2), 476-485, 2009 | 63 | 2009 |
| Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma I Roeschert, E Poon, AG Henssen, H Dorado Garcia, M Gatti, C Giansanti, ... Nature cancer 2 (3), 312-326, 2021 | 60 | 2021 |
| Phosphorylation sites on calcium channel α1 and β subunits regulate ERK-dependent modulation of neuronal N-type calcium channels SW Martin, AJ Butcher, NS Berrow, MW Richards, RE Paddon, DJ Turner, ... Cell calcium 39 (3), 275-292, 2006 | 58 | 2006 |
| Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization T Haq, MW Richards, SG Burgess, P Gallego, S Yeoh, L O’Regan, ... Nature communications 6 (1), 8771, 2015 | 57 | 2015 |
| Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression L O’Regan, J Sampson, MW Richards, A Knebel, D Roth, FE Hood, ... Journal of Cell Biology 209 (3), 349-358, 2015 | 51 | 2015 |
| The HOOK-Domain Between the SH3- and the GK-Domains of CaVβ Subunits Contains Key Determinants Controlling Calcium Channel Inactivation MW Richards, J Leroy, WS Pratt, AC Dolphin Channels 1 (2), 92-101, 2007 | 50 | 2007 |
| Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix SG Burgess, M Mukherjee, S Sabir, N Joseph, C Gutiérrez‐Caballero, ... The EMBO journal 37 (8), e97902, 2018 | 49 | 2018 |
| Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain SG Burgess, A Oleksy, T Cavazza, MW Richards, I Vernos, D Matthews, ... Open Biology 6 (7), 160089, 2016 | 49 | 2016 |
Richard BaylissProfessor, University of LeedsVerified email at leeds.ac.uk
