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Zhixiang He
Zhixiang He
Dana-Farber Cancer Institute
Verified email at dfci.harvard.edu
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Cited by
Cited by
Year
Plasticity in binding confers selectivity in ligand-induced protein degradation
RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ...
Nature chemical biology 14 (7), 706-714, 2018
4422018
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
F Fan, Z He, LL Kong, Q Chen, Q Yuan, S Zhang, J Ye, H Liu, X Sun, ...
Science translational medicine 8 (352), 352ra108-352ra108, 2016
3252016
A quantitative tissue-specific landscape of protein redox regulation during aging
H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ...
Cell 180 (5), 968-983. e24, 2020
2592020
Light-induced control of protein destruction by opto-PROTAC
J Liu, H Chen, L Ma, Z He, D Wang, Y Liu, Q Lin, T Zhang, N Gray, ...
Science advances 6 (8), eaay5154, 2020
2452020
CDK7 inhibition potentiates genome instability triggering anti-tumor immunity in small cell lung cancer
H Zhang, CL Christensen, R Dries, MG Oser, J Deng, B Diskin, F Li, Y Pan, ...
Cancer cell 37 (1), 37-54. e9, 2020
1672020
Selective degradation of GSPT1 by cereblon modulators identified via a focused combinatorial library
CE Powell, G Du, J Che, Z He, KA Donovan, H Yue, ES Wang, RP Nowak, ...
ACS chemical biology 15 (10), 2722-2730, 2020
582020
Development of CDK2 and CDK5 dual degrader TMX‐2172
M Teng, J Jiang, Z He, NP Kwiatkowski, KA Donovan, CE Mills, C Victor, ...
Angewandte Chemie 132 (33), 13969-13974, 2020
522020
Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities
W Huang, X Sun, Y Li, Z He, L Li, Z Deng, X Huang, S Han, T Zhang, ...
Journal of medicinal chemistry 61 (12), 5424-5434, 2018
382018
Exploring the target scope of KEAP1 E3 ligase-based PROTACs
G Du, J Jiang, NJ Henning, N Safaee, E Koide, RP Nowak, KA Donovan, ...
Cell chemical biology 29 (10), 1470-1481. e31, 2022
372022
Discovery of MFH290: a potent and highly selective covalent inhibitor for cyclin-dependent kinase 12/13
Y Liu, M Hao, AL Leggett, Y Gao, SB Ficarro, J Che, Z He, CM Olson, ...
Journal of Medicinal Chemistry 63 (13), 6708-6726, 2020
282020
Targeting BRK-positive breast cancers with small-molecule kinase inhibitors
J Jiang, F Gui, Z He, L Li, Y Li, S Li, X Wu, Z Deng, X Sun, X Huang, ...
Cancer research 77 (1), 175-186, 2017
272017
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
M Fan, W Lu, J Che, NP Kwiatkowski, Y Gao, HS Seo, SB Ficarro, ...
Elife 11, e78810, 2022
252022
Selective degradation-inducing probes for studying cereblon (CRBN) biology
CE Powell, G Du, JW Bushman, Z He, T Zhang, ES Fischer, NS Gray
RSC Medicinal Chemistry 12 (8), 1381-1390, 2021
182021
A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies
F Gui, J Jiang, Z He, L Li, Y Li, Z Deng, Y Lu, X Wu, G Chen, J Su, S Song, ...
British Journal of Pharmacology 176 (23), 4491-4509, 2019
172019
Discovery of covalent MKK4/7 dual inhibitor
J Jiang, B Jiang, Z He, SB Ficarro, J Che, JA Marto, Y Gao, T Zhang, ...
Cell Chemical Biology 27 (12), 1553-1560. e8, 2020
122020
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1
W Lu, Y Liu, Y Gao, Q Geng, D Gurbani, L Li, SB Ficarro, CJ Meyer, ...
Journal of Medicinal Chemistry 66 (5), 3356-3371, 2023
62023
New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
ML Arwood, Y Liu, SK Harkins, DM Weinstock, L Yang, KE Stevenson, ...
Cell chemical biology 30 (6), 618-631. e12, 2023
22023
Inhibitors of cyclin-dependent kinase 7 and uses thereof
NS Gray, T Zhang, NP Kwiatkowski, J Jiang, M Hao, Z He
US Patent App. 17/418,353, 2022
22022
Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof
NS Gray, T Zhang, Y Liu, Z He, M Hao, D Weinstock, LSM Li
US Patent App. 17/291,927, 2023
12023
Bispecific degraders
N Gray, T Zhang, E Fischer, A Verano, Z He, G Du, K Donovan, R Nowak, ...
US Patent App. 17/255,772, 2021
12021
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