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Megan Mayerle
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Protein-guided RNA dynamics during early ribosome assembly
H Kim, SC Abeysirigunawarden, K Chen, M Mayerle, K Ragunathan, ...
Nature 506 (7488), 334-338, 2014
1642014
Specific contacts between protein S4 and ribosomal RNA are required at multiple stages of ribosome assembly
M Mayerle, SA Woodson
Rna 19 (4), 574-585, 2013
292013
Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency
M Mayerle, M Raghavan, S Ledoux, A Price, N Stepankiw, ...
Proceedings of the National Academy of Sciences 114 (18), 4739-4744, 2017
282017
Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing
M Mayerle, C Guthrie
Rna 22 (5), 793-809, 2016
282016
Assembly of the five-way junction in the ribosomal small subunit using hybrid MD-Go simulations
K Chen, J Eargle, J Lai, H Kim, S Abeysirigunawardena, M Mayerle, ...
The Journal of Physical Chemistry B 116 (23), 6819-6831, 2012
282012
Slow formation of stable complexes during coincubation of minimal rRNA and ribosomal protein S4
M Mayerle, DL Bellur, SA Woodson
Journal of molecular biology 412 (3), 453-465, 2011
262011
Prp8 positioning of U5 snRNA is linked to 5′ splice site recognition
AJ MacRae, M Mayerle, E Hrabeta-Robinson, RJ Chalkley, C Guthrie, ...
Rna 24 (6), 769-777, 2018
202018
Genetics and biochemistry remain essential in the structural era of the spliceosome
M Mayerle, C Guthrie
Methods 125, 3-9, 2017
172017
Prp8 impacts cryptic but not alternative splicing frequency
M Mayerle, S Yitiz, C Soulette, LE Rogel, A Ramirez, JM Ragle, ...
Proceedings of the National Academy of Sciences 116 (6), 2193-2199, 2019
112019
Brr2 is a splicing fidelity factor
M Mayerle, C Guthrie
bioRxiv, 354514, 2018
12018
A new communication hub in the RNA world
M Mayerle, C Guthrie
Nature Structural & Molecular Biology 23 (3), 189-190, 2016
12016
Christine Guthrie (1945–2022): a tribute from her trainees
M Mayerle, HD Madhani, C Maeder
RNA 28 (12), ix-xvii, 2022
2022
A Flexible Region of PRP8 Interacts with U5 snRNA Loop I and is Functionally Linked to 5'Splice Site Recognition
A MacRae, M Mayerle, R Chalkley, M Jurica
Biophysical Journal 114 (3), 253a, 2018
2018
A" toggle" in the RNase H domain of Prp8 correlates splicing fidelity and catalytic efficiency.
M Mayerle, S Ledoux, A Price, M Raghavan, E Moehle, H Hadjivassiliou, ...
MOLECULAR BIOLOGY OF THE CELL 27, 2016
2016
Development of an smFRET Assay to Monitor Spliceosome Activation in Budding Yeast
M Mayerle, J Abelson, C Guthrie
Biophysical Journal 106 (2), 496a, 2014
2014
Single Molecule Views of the Ribosome Assembly
H Kim, S Abeysirigunawardena, M Mayerle, K Ragunathan, K Chen, ...
Biophysical Journal 102 (3), 645a, 2012
2012
Specific contacts between ribosomal protein S4 and RNA are necessary for proper ribosome assembly
M Mayerle
The Johns Hopkins University, 2012
2012
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Articles 1–17