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James J Harding, MD
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Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
A Zehir, R Benayed, RH Shah, A Syed, S Middha, HR Kim, P Srinivasan, ...
Nature medicine 23 (6), 703-713, 2017
29192017
OncoKB: a precision oncology knowledge base
D Chakravarty, J Gao, S Phillips, R Kundra, H Zhang, J Wang, ...
JCO precision oncology 1, 1-16, 2017
19382017
CheckMate 459: A randomized, multi-center phase III study of nivolumab (NIVO) vs sorafenib (SOR) as first-line (1L) treatment in patients (pts) with advanced hepatocellular …
T Yau, JW Park, RS Finn, AL Cheng, P Mathurin, J Edeline, M Kudo, ...
Annals of Oncology 30, v874-v875, 2019
7362019
HER kinase inhibition in patients with HER2-and HER3-mutant cancers
DM Hyman, SA Piha-Paul, H Won, J Rodon, C Saura, GI Shapiro, D Juric, ...
Nature 554 (7691), 189-194, 2018
6762018
Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial
T Yau, JW Park, RS Finn, AL Cheng, P Mathurin, J Edeline, M Kudo, ...
The Lancet Oncology 23 (1), 77-90, 2022
6532022
Prospective genotyping of hepatocellular carcinoma: clinical implications of next-generation sequencing for matching patients to targeted and immune therapies
JJ Harding, S Nandakumar, J Armenia, DN Khalil, M Albano, M Ly, J Shia, ...
Clinical Cancer Research 25 (7), 2116-2126, 2019
4632019
Comprehensive molecular profiling of intrahepatic and extrahepatic cholangiocarcinomas: potential targets for intervention
MA Lowery, R Ptashkin, E Jordan, MF Berger, A Zehir, M Capanu, ...
Clinical Cancer Research 24 (17), 4154-4161, 2018
4152018
TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion–positive intrahepatic cholangiocarcinoma
L Goyal, L Shi, LY Liu, F Fece de la Cruz, JK Lennerz, S Raghavan, ...
Cancer discovery 9 (8), 1064-1079, 2019
2782019
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients
B Nguyen, C Fong, A Luthra, SA Smith, RG DiNatale, S Nandakumar, ...
Cell 185 (3), 563-575. e11, 2022
2762022
Progression of RAS-mutant leukemia during RAF inhibitor treatment
MK Callahan, R Rampal, JJ Harding, VM Klimek, YR Chung, T Merghoub, ...
New England Journal of Medicine 367 (24), 2316-2321, 2012
2632012
Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression
R Busch, CH Rinderknecht, S Roh, AW Lee, JJ Harding, T Burster, ...
Immunological reviews 207 (1), 242-260, 2005
2082005
Clinical activity of ipilimumab for metastatic uveal melanoma: a retrospective review of the Dana‐Farber Cancer Institute, Massachusetts General Hospital, Memorial Sloan …
JJ Luke, MK Callahan, MA Postow, E Romano, N Ramaiya, M Bluth, ...
Cancer 119 (20), 3687-3695, 2013
2002013
First-in-humans imaging with 89Zr-Df-IAB22M2C anti-CD8 minibody in patients with solid malignancies: preliminary pharmacokinetics, biodistribution, and lesion targeting
N Pandit-Taskar, MA Postow, MD Hellmann, JJ Harding, CA Barker, ...
Journal of Nuclear Medicine 61 (4), 512-519, 2020
1862020
Real-time genomic profiling of pancreatic ductal adenocarcinoma: potential actionability and correlation with clinical phenotype
MA Lowery, EJ Jordan, O Basturk, RN Ptashkin, A Zehir, MF Berger, ...
Clinical Cancer Research 23 (20), 6094-6100, 2017
1812017
Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma
GK Abou-Alfa, S Qin, BY Ryoo, SN Lu, CJ Yen, YH Feng, HY Lim, F Izzo, ...
Annals of Oncology 29 (6), 1402-1408, 2018
1762018
Genomic methods identify homologous recombination deficiency in pancreas adenocarcinoma and optimize treatment selection
W Park, J Chen, JF Chou, AM Varghese, KH Yu, W Wong, M Capanu, ...
Clinical Cancer Research 26 (13), 3239-3247, 2020
1632020
Ipilimumab for patients with advanced mucosal melanoma
MA Postow, JJ Luke, MJ Bluth, N Ramaiya, KS Panageas, DP Lawrence, ...
The oncologist 18 (6), 726-732, 2013
1592013
Isoform switching as a mechanism of acquired resistance to mutant isocitrate dehydrogenase inhibition
JJ Harding, MA Lowery, AH Shih, JM Schvartzman, S Hou, C Famulare, ...
Cancer discovery 8 (12), 1540-1547, 2018
1582018
Assessment of hepatic arterial infusion of floxuridine in combination with systemic gemcitabine and oxaliplatin in patients with unresectable intrahepatic cholangiocarcinoma: a …
A Cercek, T Boerner, BR Tan, JF Chou, M Gönen, TM Boucher, ...
JAMA oncology 6 (1), 60-67, 2020
1482020
Phase III randomized study of sorafenib plus doxorubicin versus sorafenib in patients with advanced hepatocellular carcinoma (HCC): CALGB 80802 (Alliance).
GK Abou-Alfa, D Niedzwieski, JJ Knox, A Kaubisch, J Posey, BR Tan, ...
Journal of Clinical Oncology 34 (15_suppl), 4003-4003, 2016
1392016
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