Ruth Brenk
Ruth Brenk
Verified email at uib.no
Title
Cited by
Cited by
Year
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness
JA Frearson, S Brand, SP McElroy, LAT Cleghorn, O Smid, L Stojanovski, ...
Nature 464 (7289), 728, 2010
2602010
Lessons learnt from assembling screening libraries for drug discovery for neglected diseases
R Brenk, A Schipani, D James, A Krasowski, IH Gilbert, J Frearson, ...
ChemMedChem 3 (3), 435-444, 2008
2402008
Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry
VT Bhat, AM Caniard, T Luksch, R Brenk, DJ Campopiano, MF Greaney
Nature Chemistry 2 (6), 490-497, 2010
1592010
Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis
R Brenk, L Naerum, U Grädler, HD Gerber, GA Garcia, K Reuter, ...
Journal of medicinal chemistry 46 (7), 1133-1143, 2003
1252003
Decoys for docking
AP Graves, R Brenk, BK Shoichet
Journal of medicinal chemistry 48 (11), 3714-3728, 2005
1182005
Nucleosomes can invade DNA territories occupied by their neighbors
M Engeholm, M de Jager, A Flaus, R Brenk, J van Noort, T Owen-Hughes
Nature structural & molecular biology 16 (2), 151-158, 2009
1022009
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors
S Brand, LAT Cleghorn, SP McElroy, DA Robinson, VC Smith, ...
Journal of medicinal chemistry 55 (1), 140-152, 2011
962011
Design, synthesis, and biological evaluation of 3, 4-diarylmaleimides as angiogenesis inhibitors
C Peifer, T Stoiber, E Unger, F Totzke, C Schächtele, D Marmé, R Brenk, ...
Journal of medicinal chemistry 49 (4), 1271-1281, 2006
952006
One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening
CP Mpamhanga, D Spinks, LB Tulloch, EJ Shanks, DA Robinson, ...
Journal of medicinal chemistry 52 (14), 4454-4465, 2009
932009
Novel ligands for a purine riboswitch discovered by RNA-ligand docking
P Daldrop, FE Reyes, DA Robinson, CM Hammond, DM Lilley, RT Batey, ...
Chemistry & biology 18 (3), 324-335, 2011
832011
Probing molecular docking in a charged model binding site
R Brenk, SW Vetter, SE Boyce, DB Goodin, BK Shoichet
Journal of molecular biology 357 (5), 1449-1470, 2006
682006
DrugPred: a structure-based approach to predict protein druggability developed using an extensive nonredundant data set
A Krasowski, D Muthas, A Sarkar, S Schmitt, R Brenk
Journal of chemical information and modeling 51 (11), 2829-2842, 2011
662011
Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation …
B Stengl, EA Meyer, A Heine, R Brenk, F Diederich, G Klebe
Journal of molecular biology 370 (3), 492-511, 2007
642007
Identification of Inhibitors of the Leishmania cdc2‐Related Protein Kinase CRK3
LAT Cleghorn, A Woodland, IT Collie, LS Torrie, N Norcross, T Luksch, ...
ChemMedChem 6 (12), 2214-2224, 2011
512011
Synthesis and In Vitro Evaluation of 2‐Aminoquinazolin‐4 (3H)‐one‐Based Inhibitors for tRNA‐Guanine Transglycosylase (TGT)
EA Meyer, M Furler, F Diederich, R Brenk, G Klebe
Helvetica chimica acta 87 (6), 1333-1356, 2004
502004
Here be dragons: docking and screening in an uncharted region of chemical space
R Brenk, JJ Irwin, BK Shoichet
Journal of biomolecular screening 10 (7), 667-674, 2005
482005
De Novo Design, Synthesis, and In Vitro Evaluation of Inhibitors for Prokaryotic tRNA‐Guanine Transglycosylase: A Dramatic Sulfur Effect on Binding Affinity
EA Meyer, R Brenk, RK Castellano, M Furler, G Klebe, F Diederich
ChemBioChem 3 (2‐3), 250-253, 2002
482002
Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening
R Brenk, EA Meyer, K Reuter, MT Stubbs, GA Garcia, F Diederich, ...
Journal of molecular biology 338 (1), 55-75, 2004
472004
Mining the ChEMBL database: an efficient chemoinformatics workflow for assembling an ion channel-focused screening library
NY Mok, R Brenk
Journal of chemical information and modeling 51 (10), 2449-2454, 2011
462011
Mining the ChEMBL database: an efficient chemoinformatics workflow for assembling an ion channel-focused screening library
NY Mok, R Brenk
Journal of chemical information and modeling 51 (10), 2449-2454, 2011
462011
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