| Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate MP Hall, J Unch, BF Binkowski, MP Valley, BL Butler, MG Wood, P Otto, ... ACS chemical biology 7 (11), 1848-1857, 2012 | 1491 | 2012 |
| Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB T Henkel, T Machleidt, I Alkalay, M Krönke, Y Ben-Neriah, PA Baeuerle Nature 365 (6442), 182-185, 1993 | 1407 | 1993 |
| TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “acidic” sphingomyelin breakdown S Schütze, K Potthoff, T Machleidt, D Berkovic, K Wiegmann, M Krönke Cell 71 (5), 765-776, 1992 | 1222 | 1992 |
| NanoLuc complementation reporter optimized for accurate measurement of protein interactions in cells AS Dixon, MK Schwinn, MP Hall, K Zimmerman, P Otto, TH Lubben, ... ACS chemical biology 11 (2), 400-408, 2016 | 1050 | 2016 |
| Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling K Wiegmann, S Schütze, T Machleidt, D Witte, M Krönke Cell 78 (6), 1005-1015, 1994 | 900 | 1994 |
| NanoBRET A Novel BRET Platform for the Analysis of Protein–Protein Interactions T Machleidt, CC Woodroofe, MK Schwinn, J Méndez, MB Robers, ... ACS chemical biology 10 (8), 1797-1804, 2015 | 445 | 2015 |
| Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton DI Mundy, T Machleidt, Y Ying, RGW Anderson, GS Bloom Journal of cell science 115 (22), 4327-4339, 2002 | 382 | 2002 |
| Discovery of potent and selective covalent inhibitors of JNK T Zhang, F Inesta-Vaquera, M Niepel, J Zhang, SB Ficarro, T Machleidt, ... Chemistry & biology 19 (1), 140-154, 2012 | 353 | 2012 |
| TNF-induced activation of NF-κB S Schütze, K Wiegmann, T Machleidt, M Krönke Immunobiology 193 (2-4), 193-203, 1995 | 336 | 1995 |
| Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex V Nunbhakdi-Craig, T Machleidt, E Ogris, D Bellotto, CL White III, ... The Journal of cell biology 158 (5), 967-978, 2002 | 332 | 2002 |
| CRISPR-mediated tagging of endogenous proteins with a luminescent peptide MK Schwinn, T Machleidt, K Zimmerman, CT Eggers, AS Dixon, R Hurst, ... ACS chemical biology 13 (2), 467-474, 2018 | 292 | 2018 |
| Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades. K Wiegmann, S Schütze, E Kampen, A Himmler, T Machleidt, M Krönke Journal of Biological Chemistry 267 (25), 17997-18001, 1992 | 267 | 1992 |
| The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction S Schütze, T Machleidt, M Krönke Journal of Leucocyte Biology 56 (5), 533-541, 1994 | 261 | 1994 |
| Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling S Schutze, T Machleidt, D Adam, R Schwandner, K Wiegmann, ML Kruse, ... Journal of Biological Chemistry 274 (15), 10203-10212, 1999 | 258 | 1999 |
| Application of BRET to monitor ligand binding to GPCRs LA Stoddart, EKM Johnstone, AJ Wheal, J Goulding, MB Robers, ... Nature methods 12 (7), 661-663, 2015 | 250 | 2015 |
| Target engagement and drug residence time can be observed in living cells with BRET MB Robers, ML Dart, CC Woodroofe, CA Zimprich, TA Kirkland, ... Nature communications 6 (1), 10091, 2015 | 248 | 2015 |
| CD28 signals through acidic sphingomyelinase. LM Boucher, K Wiegmann, A Fütterer, K Pfeffer, T Machleidt, S Schütze, ... The Journal of experimental medicine 181 (6), 2059-2068, 1995 | 239 | 1995 |
| Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration. B Neumann, T Machleidt, A Lifka, K Pfeffer, D Vestweber, TW Mak, ... Journal of immunology (Baltimore, Md.: 1950) 156 (4), 1587-1593, 1996 | 229 | 1996 |
| Identification of a new JNK inhibitor targeting the JNK-JIP interaction site JL Stebbins, SK De, T Machleidt, B Becattini, J Vazquez, C Kuntzen, ... Proceedings of the National Academy of Sciences 105 (43), 16809-16813, 2008 | 223 | 2008 |
| Quantitative, wide-spectrum kinase profiling in live cells for assessing the effect of cellular ATP on target engagement JD Vasta, CR Corona, J Wilkinson, CA Zimprich, JR Hartnett, MR Ingold, ... Cell chemical biology 25 (2), 206-214. e11, 2018 | 212 | 2018 |
Thomas Andrew KirklandPromega BiosciencesVerified email at promega.com
