|Effect of detergent on “promiscuous” inhibitors|
AJ Ryan, NM Gray, PN Lowe, C Chung
Journal of medicinal chemistry 46 (16), 3448-3451, 2003
|Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin|
AJ Ryan, J Ghuman, PA Zunszain, C Chung, S Curry
Journal of structural biology 174 (1), 84-91, 2011
|Arylamine N‐acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery|
E Sim, A Abuhammad, A Ryan
British journal of pharmacology 171 (11), 2705-2725, 2014
|A novel mechanism for azoreduction|
A Ryan, N Laurieri, I Westwood, CJ Wang, E Lowe, E Sim
Journal of molecular biology 400 (1), 24-37, 2010
|Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases|
A Ryan, CJ Wang, N Laurieri, I Westwood, E Sim
Protein & cell 1 (8), 780-790, 2010
|Identification of NAD (P) H quinone oxidoreductase activity in azoreductases from P. aeruginosa: azoreductases and NAD (P) H quinone oxidoreductases belong to the same FMN …|
A Ryan, E Kaplan, JC Nebel, E Polycarpou, V Crescente, E Lowe, ...
PloS one 9 (6), e98551, 2014
|Crystallographic analysis reveals the structural basis of the high-affinity binding of iophenoxic acid to human serum albumin|
AJ Ryan, C Chung, S Curry
BMC structural biology 11 (1), 1-7, 2011
|Activation of nitrofurazone by azoreductases: multiple activities in one enzyme|
A Ryan, E Kaplan, N Laurieri, E Lowe, E Sim
Scientific reports 1 (1), 1-5, 2011
|Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide|
CJ Wang, N Laurieri, A Abuhammad, E Lowe, I Westwood, A Ryan, E Sim
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2010
|Azoreductases in drug metabolism|
British journal of pharmacology 174 (14), 2161-2173, 2017
|Primary sequence contribution to the optical function of the eye lens|
K Mahendiran, C Elie, JC Nebel, A Ryan, BK Pierscionek
Scientific Reports 4 (1), 1-8, 2014
|Structure–activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1|
JE Egleton, CC Thinnes, PT Seden, N Laurieri, SP Lee, KS Hadavizadeh, ...
Bioorganic & medicinal chemistry 22 (11), 3030-3054, 2014
|Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti‐tubercular agents using a fragment‐based drug design approach|
A Ryan, E Polycarpou, NA Lack, D Evangelopoulos, C Sieg, A Halman, ...
British journal of pharmacology 174 (14), 2209-2224, 2017
|The role of apolipoprotein N‐acyl transferase, Lnt, in the lipidation of factor H binding protein of Neisseria meningitidis strain MC58 and its potential as a drug target|
RAG da Silva, CP Churchward, AV Karlyshev, O Eleftheriadou, ...
British journal of pharmacology 174 (14), 2247-2260, 2017
|Identification of novel members of the bacterial azoreductase family in Pseudomonas aeruginosa|
V Crescente, SM Holland, S Kashyap, E Polycarpou, E Sim, A Ryan
Biochemical Journal 473 (5), 549-558, 2016
|Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy|
O Eleftheriadou, A Boguslavskyi, MR Longman, J Cowan, A Francois, ...
Basic research in cardiology 112 (4), 37, 2017
|Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues|
T Tsirka, M Konstantopoulou, A Sabbagh, B Crouau-Roy, A Ryan, E Sim, ...
Scientific reports 8 (1), 1-13, 2018
|Purification, quantification, and functional analysis of Complement Factor H|
BB Yu, BE Moffatt, M Fedorova, CGS Villiers, JN Arnold, E Du, A Swinkels, ...
The Complement System, 207-223, 2014
|Mechanism-based inhibition of HsaD: a C-C bond hydrolase essential for survival of Mycobacterium tuberculosis in macrophage|
A Ryan, S Keany, O Eleftheriadou, R Ballet, HY Cheng, E Sim
FEMS microbiology letters 350 (1), 42-47, 2014
|Variant signal peptides of vaccine antigen, FHbp, impair processing affecting surface localization and antibody-mediated killing in most meningococcal isolates|
RAG da Silva, AV Karlyshev, NJ Oldfield, KG Wooldridge, CD Bayliss, ...
Frontiers in microbiology 10, 2847, 2019