Celeste M Karch
Celeste M Karch
Associate Professor of Psychiatry, Washington University in St Louis
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Cited by
Cited by
Alzheimer’s disease risk genes and mechanisms of disease pathogenesis
CM Karch, AM Goate
Biological psychiatry 77 (1), 43-51, 2015
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
C Cruchaga, CM Karch, SC Jin, BA Benitez, Y Cai, R Guerreiro, O Harari, ...
Nature 505 (7484), 550-554, 2014
Alzheimer’s disease genetics: from the bench to the clinic
CM Karch, C Cruchaga, AM Goate
Neuron 83 (1), 11-26, 2014
Tau kinetics in neurons and the human central nervous system
C Sato, NR Barthélemy, KG Mawuenyega, BW Patterson, BA Gordon, ...
Neuron 97 (6), 1284-1298. e7, 2018
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer’s disease
C Cruchaga, JSK Kauwe, O Harari, SC Jin, Y Cai, CM Karch, BA Benitez, ...
Neuron 78 (2), 256-268, 2013
Expression of novel Alzheimer’s disease risk genes in control and Alzheimer’s disease brains
CM Karch, AT Jeng, P Nowotny, J Cady, C Cruchaga, AM Goate
PloS one 7 (11), e50976, 2012
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
RS Desikan, CC Fan, Y Wang, AJ Schork, HJ Cabral, LA Cupples, ...
PLoS medicine 14 (3), e1002258, 2017
Coding variants in TREM2 increase risk for Alzheimer's disease
SC Jin, BA Benitez, CM Karch, B Cooper, T Skorupa, D Carrell, JB Norton, ...
Human molecular genetics 23 (21), 5838-5846, 2014
An efficient platform for astrocyte differentiation from human induced pluripotent stem cells
TCW Julia, M Wang, AA Pimenova, KR Bowles, BJ Hartley, E Lacin, ...
Stem cell reports 9 (2), 600-614, 2017
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
NR Barthélemy, Y Li, N Joseph-Mathurin, BA Gordon, J Hassenstab, ...
Nature medicine 26 (3), 398-407, 2020
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
CM Karch, M Prudencio, DD Winkler, PJ Hart, DR Borchelt
Proceedings of the National Academy of Sciences 106 (19), 7774-7779, 2009
Extracellular tau levels are influenced by variability in tau that is associated with tauopathies
CM Karch, AT Jeng, AM Goate
Journal of Biological Chemistry, 2012
Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening
C Wang, ME Ward, R Chen, K Liu, TE Tracy, X Chen, M Xie, PD Sohn, ...
Stem cell reports 9 (4), 1221-1233, 2017
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
U Dube, JL Del-Aguila, Z Li, JP Budde, S Jiang, S Hsu, L Ibanez, ...
Nature neuroscience 22 (11), 1903-1912, 2019
Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: αB-crystallin modulates aggregation
J Wang, G Xu, H Li, V Gonzales, D Fromholt, C Karch, NG Copeland, ...
Human molecular genetics 14 (16), 2335-2347, 2005
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
DL Kober, JM Alexander-Brett, CM Karch, C Cruchaga, M Colonna, ...
elife 5, e20391, 2016
Association between genetic traits for immune-mediated diseases and Alzheimer disease
JS Yokoyama, Y Wang, AJ Schork, WK Thompson, CM Karch, ...
JAMA neurology 73 (6), 691-697, 2016
A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis
CM Karch, DR Borchelt
Journal of Biological Chemistry 283 (20), 13528-13537, 2008
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Y Deming, F Filipello, F Cignarella, C Cantoni, S Hsu, R Mikesell, Z Li, ...
Science translational medicine 11 (505), eaau2291, 2019
Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis
SV Seetharaman, M Prudencio, C Karch, SP Holloway, DR Borchelt, ...
Experimental biology and medicine 234 (10), 1140-1154, 2009
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