| Alzheimer’s disease risk genes and mechanisms of disease pathogenesis CM Karch, AM Goate Biological psychiatry 77 (1), 43-51, 2015 | 1380 | 2015 |
| Tau kinetics in neurons and the human central nervous system C Sato, NR Barthélemy, KG Mawuenyega, BW Patterson, BA Gordon, ... Neuron 97 (6), 1284-1298. e7, 2018 | 530 | 2018 |
| Alzheimer’s disease genetics: from the bench to the clinic CM Karch, C Cruchaga, AM Goate Neuron 83 (1), 11-26, 2014 | 524 | 2014 |
| Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease C Cruchaga, CM Karch, SC Jin, BA Benitez, Y Cai, R Guerreiro, O Harari, ... Nature 505 (7484), 550-554, 2014 | 522 | 2014 |
| A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease NR Barthélemy, Y Li, N Joseph-Mathurin, BA Gordon, J Hassenstab, ... Nature medicine 26 (3), 398-407, 2020 | 420 | 2020 |
| Genetic assessment of age-associated Alzheimer disease risk: development and validation of a polygenic hazard score RS Desikan, CC Fan, Y Wang, AJ Schork, HJ Cabral, LA Cupples, ... PLoS medicine 14 (3), e1002258, 2017 | 385 | 2017 |
| GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer’s disease C Cruchaga, JSK Kauwe, O Harari, SC Jin, Y Cai, CM Karch, BA Benitez, ... Neuron 78 (2), 256-268, 2013 | 379 | 2013 |
| Expression of novel Alzheimer’s disease risk genes in control and Alzheimer’s disease brains CM Karch, AT Jeng, P Nowotny, J Cady, C Cruchaga, AM Goate PloS one 7 (11), e50976, 2012 | 369 | 2012 |
| An efficient platform for astrocyte differentiation from human induced pluripotent stem cells TCW Julia, M Wang, AA Pimenova, KR Bowles, BJ Hartley, E Lacin, ... Stem cell reports 9 (2), 600-614, 2017 | 361 | 2017 |
| Coding variants in TREM2 increase risk for Alzheimer's disease SC Jin, BA Benitez, CM Karch, B Cooper, T Skorupa, D Carrell, JB Norton, ... Human molecular genetics 23 (21), 5838-5846, 2014 | 294 | 2014 |
| Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening C Wang, ME Ward, R Chen, K Liu, TE Tracy, X Chen, M Xie, PD Sohn, ... Stem cell reports 9 (4), 1221-1233, 2017 | 266 | 2017 |
| An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations U Dube, JL Del-Aguila, Z Li, JP Budde, S Jiang, S Hsu, L Ibanez, ... Nature neuroscience 22 (11), 1903-1912, 2019 | 260 | 2019 |
| Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS CM Karch, M Prudencio, DD Winkler, PJ Hart, DR Borchelt Proceedings of the National Academy of Sciences 106 (19), 7774-7779, 2009 | 228 | 2009 |
| The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk Y Deming, F Filipello, F Cignarella, C Cantoni, S Hsu, R Mikesell, Z Li, ... Science translational medicine 11 (505), eaau2291, 2019 | 206 | 2019 |
| Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy S Da Mesquita, Z Papadopoulos, T Dykstra, L Brase, FG Farias, M Wall, ... Nature 593 (7858), 255-260, 2021 | 201 | 2021 |
| Extracellular tau levels are influenced by variability in tau that is associated with tauopathies CM Karch, AT Jeng, AM Goate Journal of Biological Chemistry, 2012 | 195 | 2012 |
| Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology M Suárez-Calvet, E Morenas-Rodríguez, G Kleinberger, K Schlepckow, ... Molecular neurodegeneration 14, 1-14, 2019 | 191 | 2019 |
| Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms DL Kober, JM Alexander-Brett, CM Karch, C Cruchaga, M Colonna, ... elife 5, e20391, 2016 | 183 | 2016 |
| Association between genetic traits for immune-mediated diseases and Alzheimer disease JS Yokoyama, Y Wang, AJ Schork, WK Thompson, CM Karch, ... JAMA neurology 73 (6), 691-697, 2016 | 157 | 2016 |
| Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: αB-crystallin modulates aggregation J Wang, G Xu, H Li, V Gonzales, D Fromholt, C Karch, NG Copeland, ... Human molecular genetics 14 (16), 2335-2347, 2005 | 151 | 2005 |
Alison GoateProfessor of Genetics & Genomic Sciences, Icahn School of Medicine at Mount SinaiVerified email at mssm.edu
