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Celeste M Karch
Celeste M Karch
Associate Professor of Psychiatry, Washington University in St Louis
Verified email at wustl.edu
Title
Cited by
Cited by
Year
Alzheimer’s disease risk genes and mechanisms of disease pathogenesis
CM Karch, AM Goate
Biological psychiatry 77 (1), 43-51, 2015
10392015
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
C Cruchaga, CM Karch, SC Jin, BA Benitez, Y Cai, R Guerreiro, O Harari, ...
Nature 505 (7484), 550-554, 2014
4612014
Alzheimer’s disease genetics: from the bench to the clinic
CM Karch, C Cruchaga, AM Goate
Neuron 83 (1), 11-26, 2014
4452014
Tau kinetics in neurons and the human central nervous system
C Sato, NR Barthélemy, KG Mawuenyega, BW Patterson, BA Gordon, ...
Neuron 97 (6), 1284-1298. e7, 2018
3612018
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer’s disease
C Cruchaga, JSK Kauwe, O Harari, SC Jin, Y Cai, CM Karch, BA Benitez, ...
Neuron 78 (2), 256-268, 2013
3252013
Expression of novel Alzheimer’s disease risk genes in control and Alzheimer’s disease brains
CM Karch, AT Jeng, P Nowotny, J Cady, C Cruchaga, AM Goate
PloS one 7 (11), e50976, 2012
2962012
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
RS Desikan, CC Fan, Y Wang, AJ Schork, HJ Cabral, LA Cupples, ...
PLoS medicine 14 (3), e1002258, 2017
2862017
Coding variants in TREM2 increase risk for Alzheimer's disease
SC Jin, BA Benitez, CM Karch, B Cooper, T Skorupa, D Carrell, JB Norton, ...
Human molecular genetics 23 (21), 5838-5846, 2014
2382014
An efficient platform for astrocyte differentiation from human induced pluripotent stem cells
TCW Julia, M Wang, AA Pimenova, KR Bowles, BJ Hartley, E Lacin, ...
Stem cell reports 9 (2), 600-614, 2017
2302017
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
NR Barthélemy, Y Li, N Joseph-Mathurin, BA Gordon, J Hassenstab, ...
Nature medicine 26 (3), 398-407, 2020
2222020
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
CM Karch, M Prudencio, DD Winkler, PJ Hart, DR Borchelt
Proceedings of the National Academy of Sciences 106 (19), 7774-7779, 2009
2122009
Extracellular tau levels are influenced by variability in tau that is associated with tauopathies
CM Karch, AT Jeng, AM Goate
Journal of Biological Chemistry, 2012
1762012
Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening
C Wang, ME Ward, R Chen, K Liu, TE Tracy, X Chen, M Xie, PD Sohn, ...
Stem cell reports 9 (4), 1221-1233, 2017
1512017
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
U Dube, JL Del-Aguila, Z Li, JP Budde, S Jiang, S Hsu, L Ibanez, ...
Nature neuroscience 22 (11), 1903-1912, 2019
1442019
Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: αB-crystallin modulates aggregation
J Wang, G Xu, H Li, V Gonzales, D Fromholt, C Karch, NG Copeland, ...
Human molecular genetics 14 (16), 2335-2347, 2005
1402005
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
DL Kober, JM Alexander-Brett, CM Karch, C Cruchaga, M Colonna, ...
elife 5, e20391, 2016
1392016
Association between genetic traits for immune-mediated diseases and Alzheimer disease
JS Yokoyama, Y Wang, AJ Schork, WK Thompson, CM Karch, ...
JAMA neurology 73 (6), 691-697, 2016
1282016
A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis
CM Karch, DR Borchelt
Journal of Biological Chemistry 283 (20), 13528-13537, 2008
1232008
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Y Deming, F Filipello, F Cignarella, C Cantoni, S Hsu, R Mikesell, Z Li, ...
Science translational medicine 11 (505), eaau2291, 2019
1152019
Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis
SV Seetharaman, M Prudencio, C Karch, SP Holloway, DR Borchelt, ...
Experimental biology and medicine 234 (10), 1140-1154, 2009
1152009
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