|Targeting histone lysine demethylases—progress, challenges, and the future|
CC Thinnes, KS England, A Kawamura, R Chowdhury, CJ Schofield, ...
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1839 (12 …, 2014
|5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation|
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical science 4 (8), 3110-3117, 2013
|Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials|
TL Yeh, TM Leissing, MI Abboud, CC Thinnes, O Atasoylu, JP Holt-Martyn, ...
Chemical science 8 (11), 7651-7668, 2017
|Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models|
SS Karuppagounder, I Alim, SJ Khim, MW Bourassa, SF Sleiman, R John, ...
Science translational medicine 8 (328), 328ra29-328ra29, 2016
|Glucose metabolism and oxygen availability govern reactivation of the latent human retrovirus HTLV-1|
A Kulkarni, M Mateus, CC Thinnes, JS McCullagh, CJ Schofield, ...
Cell chemical biology 24 (11), 1377-1387. e3, 2017
|Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases|
CC Thinnes, A Tumber, C Yapp, G Scozzafava, T Yeh, MC Chan, TA Tran, ...
Chemical Communications 51 (84), 15458-15461, 2015
|Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio-and stereoselectivity of prolyl hydroxylases|
S Horita, JS Scotti, C Thinnes, YS Mottaghi-Taromsari, A Thalhammer, ...
Structure 23 (4), 639-652, 2015
|A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1|
N Laurieri, JE Egleton, A Varney, CC Thinnes, CE Quevedo, PT Seden, ...
PloS one 8 (8), e70600, 2013
|Structure–activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1|
JE Egleton, CC Thinnes, PT Seden, N Laurieri, SP Lee, KS Hadavizadeh, ...
Bioorganic & medicinal chemistry 22 (11), 3030-3054, 2014
|Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson’s disease|
J Hertel, AC Harms, A Heinken, F Baldini, CC Thinnes, E Glaab, ...
Cell reports 29 (7), 1767-1777. e8, 2019
|Tetracyanoresorcin  arene selectively recognises trimethyllysine and inhibits its enzyme-catalysed demethylation|
H Peacock, CC Thinnes, A Kawamura, AD Hamilton
Supramolecular Chemistry 28 (5-6), 575-581, 2016
|Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia …|
S Kiriakidis, SS Hoer, N Burrows, G Biddlecome, MN Khan, CC Thinnes, ...
Kidney international 92 (4), 900-908, 2017
|Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions|
F Baldini, J Hertel, E Sandt, CC Thinnes, L Neuberger-Castillo, L Pavelka, ...
BMC Biology 18 (1), 1-21, 2020
|Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding|
CC Thinnes, CT Lohans, MI Abboud, TL Yeh, A Tumber, RP Nowak, ...
Chemistry–A European Journal 25 (8), 2019-2024, 2019
|Parkinson's disease-associated alterations of the gut microbiome can invoke disease-relevant metabolic changes|
F Baldini, J Hertel, E Sandt, C Thinnes, L Neuberger-Castillo, L Pavelka, ...
bioRxiv, 691030, 2019
|Epigenetic drug discovery: Prospects in terms of technology, market, and organizational capabilities|
CC Thinnes, MJ Ventresca
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248, 2014
|Chemical and biological studies on human oxygenases|
Oxford University, UK, 2014
|Optimisation of Isoenzyme-Specific Reagents: Organic Synthesis and Biological Characterisation of Naphthoquinones as Selective Inhibitors of Human n-Acetyltransferase 1 (hnat1 …|
N Laurieri, C Thinnes, I Westwood, B Pedro, P Seden, SG Davies, ...