Cyrille C. Thinnes
Cyrille C. Thinnes
Verified email at nuigalway.ie - Homepage
Title
Cited by
Cited by
Year
Targeting histone lysine demethylases—progress, challenges, and the future
CC Thinnes, KS England, A Kawamura, R Chowdhury, CJ Schofield, ...
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1839 (12 …, 2014
1532014
5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical science 4 (8), 3110-3117, 2013
1032013
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models
SS Karuppagounder, I Alim, SJ Khim, MW Bourassa, SF Sleiman, R John, ...
Science translational medicine 8 (328), 328ra29-328ra29, 2016
532016
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
TL Yeh, TM Leissing, MI Abboud, CC Thinnes, O Atasoylu, JP Holt-Martyn, ...
Chemical science 8 (11), 7651-7668, 2017
452017
Glucose metabolism and oxygen availability govern reactivation of the latent human retrovirus HTLV-1
A Kulkarni, M Mateus, CC Thinnes, JS McCullagh, CJ Schofield, ...
Cell chemical biology 24 (11), 1377-1387. e3, 2017
282017
Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases
CC Thinnes, A Tumber, C Yapp, G Scozzafava, T Yeh, MC Chan, TA Tran, ...
Chemical Communications 51 (84), 15458-15461, 2015
262015
Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio-and stereoselectivity of prolyl hydroxylases
S Horita, JS Scotti, C Thinnes, YS Mottaghi-Taromsari, A Thalhammer, ...
Structure 23 (4), 639-652, 2015
232015
A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1
N Laurieri, JE Egleton, A Varney, CC Thinnes, CE Quevedo, PT Seden, ...
PloS one 8 (8), 2013
162013
Structure–activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1
JE Egleton, CC Thinnes, PT Seden, N Laurieri, SP Lee, KS Hadavizadeh, ...
Bioorganic & medicinal chemistry 22 (11), 3030-3054, 2014
152014
Tetracyanoresorcin [4] arene selectively recognises trimethyllysine and inhibits its enzyme-catalysed demethylation
H Peacock, CC Thinnes, A Kawamura, AD Hamilton
Supramolecular Chemistry 28 (5-6), 575-581, 2016
112016
Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia …
S Kiriakidis, SS Hoer, N Burrows, G Biddlecome, MN Khan, CC Thinnes, ...
Kidney international 92 (4), 900-908, 2017
72017
Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease
J Hertel, AC Harms, A Heinken, F Baldini, CC Thinnes, E Glaab, ...
Cell reports 29 (7), 1767-1777. e8, 2019
12019
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding
CC Thinnes, CT Lohans, MI Abboud, TL Yeh, A Tumber, RP Nowak, ...
Chemistry–A European Journal 25 (8), 2019-2024, 2019
12019
Parkinson's disease-associated alterations of the gut microbiome can invoke disease-relevant metabolic changes
F Baldini, J Hertel, E Sandt, C Thinnes, L Neuberger-Castillo, L Pavelka, ...
bioRxiv, 691030, 2019
2019
Epigenetic drug discovery: Prospects in terms of technology, market, and organizational capabilities
CC Thinnes, MJ Ventresca
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248, 2014
2014
Chemical and biological studies on human oxygenases
CC Thinnes
Oxford University, UK, 2014
2014
Optimisation of Isoenzyme-Specific Reagents: Organic Synthesis and Biological Characterisation of Naphthoquinones as Selective Inhibitors of Human n-Acetyltransferase 1 (hnat1 …
N Laurieri, C Thinnes, I Westwood, B Pedro, P Seden, SG Davies, ...
2010
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Articles 1–17