| Targeting histone lysine demethylases—progress, challenges, and the future CC Thinnes, KS England, A Kawamura, R Chowdhury, CJ Schofield, ... Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1839 (12 …, 2014 | 170 | 2014 |
| 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ... Chemical science 4 (8), 3110-3117, 2013 | 123 | 2013 |
| Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials TL Yeh, TM Leissing, MI Abboud, CC Thinnes, O Atasoylu, JP Holt-Martyn, ... Chemical science 8 (11), 7651-7668, 2017 | 92 | 2017 |
| Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models SS Karuppagounder, I Alim, SJ Khim, MW Bourassa, SF Sleiman, R John, ... Science translational medicine 8 (328), 328ra29-328ra29, 2016 | 74 | 2016 |
| Glucose metabolism and oxygen availability govern reactivation of the latent human retrovirus HTLV-1 A Kulkarni, M Mateus, CC Thinnes, JS McCullagh, CJ Schofield, ... Cell chemical biology 24 (11), 1377-1387. e3, 2017 | 41 | 2017 |
| Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases CC Thinnes, A Tumber, C Yapp, G Scozzafava, T Yeh, MC Chan, TA Tran, ... Chemical Communications 51 (84), 15458-15461, 2015 | 31 | 2015 |
| Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio-and stereoselectivity of prolyl hydroxylases S Horita, JS Scotti, C Thinnes, YS Mottaghi-Taromsari, A Thalhammer, ... Structure 23 (4), 639-652, 2015 | 26 | 2015 |
| Structure–activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1 JE Egleton, CC Thinnes, PT Seden, N Laurieri, SP Lee, KS Hadavizadeh, ... Bioorganic & medicinal chemistry 22 (11), 3030-3054, 2014 | 20 | 2014 |
| Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson’s disease J Hertel, AC Harms, A Heinken, F Baldini, CC Thinnes, E Glaab, ... Cell reports 29 (7), 1767-1777. e8, 2019 | 19 | 2019 |
| A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1 N Laurieri, JE Egleton, A Varney, CC Thinnes, CE Quevedo, PT Seden, ... PloS one 8 (8), e70600, 2013 | 18 | 2013 |
| Tetracyanoresorcin [4] arene selectively recognises trimethyllysine and inhibits its enzyme-catalysed demethylation H Peacock, CC Thinnes, A Kawamura, AD Hamilton Supramolecular Chemistry 28 (5-6), 575-581, 2016 | 14 | 2016 |
| Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions F Baldini, J Hertel, E Sandt, CC Thinnes, L Neuberger-Castillo, L Pavelka, ... BMC biology 18 (1), 1-21, 2020 | 12 | 2020 |
| Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia … S Kiriakidis, SS Hoer, N Burrows, G Biddlecome, MN Khan, CC Thinnes, ... Kidney international 92 (4), 900-908, 2017 | 8 | 2017 |
| Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding CC Thinnes, CT Lohans, MI Abboud, TL Yeh, A Tumber, RP Nowak, ... Chemistry (Weinheim an der Bergstrasse, Germany) 25 (8), 2019 | 2 | 2019 |
| Parkinson’s disease-associated alterations of the gut microbiome can invoke disease-relevant metabolic changes F Baldini, J Hertel, E Sandt, CC Thinnes, L Neuberger-Castillo, L Pavelka, ... bioRxiv, 691030, 2019 | 1 | 2019 |
| Epigenetic drug discovery: Prospects in terms of technology, market, and organizational capabilities CC Thinnes, MJ Ventresca ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248, 2014 | | 2014 |
| Chemical and biological studies on human oxygenases CC Thinnes Oxford University, UK, 2014 | | 2014 |
| Optimisation of Isoenzyme-Specific Reagents: Organic Synthesis and Biological Characterisation of Naphthoquinones as Selective Inhibitors of Human n-Acetyltransferase 1 (hnat1 … N Laurieri, C Thinnes, I Westwood, B Pedro, P Seden, SG Davies, ... | | 2010 |
Martine I. AbboudUniversity of OxfordVerified email at chem.ox.ac.uk
