Mike Sutcliffe
Mike Sutcliffe
Deputy Dean, TEDI-London
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Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures
MJ Sutcliffe, I Haneef, D Carney, TL Blundell
Protein Engineering, Design and Selection 1 (5), 377-384, 1987
An automated approach for clustering an ensemble of NMR-derived protein structures into conformationally related subfamilies
LA Kelley, SP Gardner, MJ Sutcliffe
Protein Engineering, Design and Selection 9 (11), 1063-1065, 1996
Crystal structure of a PDZ domain
JHM Cabral, C Petosa, MJ Sutcliffe, S Raza, O Byron, F Poy, SM Marfatia, ...
Nature 382 (6592), 649-652, 1996
Atomic description of an enzyme reaction dominated by proton tunneling
L Masgrau, A Roujeinikova, LO Johannissen, P Hothi, J Basran, ...
Science 312 (5771), 237-241, 2006
Knowledge‐based protein modelling and design
T Blundell, D Carney, S Gardner, F Hayes, B Howlin, T Hubbard, ...
European Journal of Biochemistry 172 (3), 513-520, 1988
Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains
MJ Sutcliffe, FRF Hayes, TL Blundell
Protein Engineering, Design and Selection 1 (5), 385-392, 1987
Enzymatic H-transfer requires vibration-driven extreme tunneling
J Basran, MJ Sutcliffe, NS Scrutton
Biochemistry 38 (10), 3218-3222, 1999
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: sequential metabolism of deltamethrin revealed
BJ Stevenson, J Bibby, P Pignatelli, S Muangnoicharoen, PM O’Neill, ...
Insect biochemistry and molecular biology 41 (7), 492-502, 2011
A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.
PR Stanfield, NW Davies, PA Shelton, MJ Sutcliffe, IA Khan, WJ Brammar, ...
The Journal of physiology 478 (1), 1-6, 1994
Ligand binding to integrin αIIbβ3 is dependent on a MIDAS-like domain in the β3 subunit
EC Tozer, RC Liddington, MJ Sutcliffe, AH Smeeton, JC Loftus
Journal of Biological Chemistry 271 (36), 21978-21984, 1996
A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding
S Modi, MJ Paine, MJ Sutcliffe, LY Lian, WU Primrose, CR Wolf, ...
Biochemistry 35 (14), 4540-4550, 1996
A single mutation in cytochrome P450 BM3 changes substrate orientation in a catalytic intermediate and the regiospecificity of hydroxylation
CF Oliver, S Modi, MJ Sutcliffe, WU Primrose, LY Lian, GCK Roberts
Biochemistry 36 (7), 1567-1572, 1997
TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies
M MacFarlane, SL Kohlhaas, MJ Sutcliffe, MJS Dyer, GM Cohen
Cancer research 65 (24), 11265-11270, 2005
A new conceptual framework for enzyme catalysis: Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes
MJ Sutcliffe, NS Scrutton
European Journal of Biochemistry 269 (13), 3096-3102, 2002
Biodiversity of cytochrome P450 redox systems
KJ McLean, M Sabri, KR Marshall, RJ Lawson, DG Lewis, D Clift, ...
Biochemical Society Transactions 33 (4), 796-801, 2005
The catalytic mechanism of cytochrome P450 BM3 involves a 6 movement of the bound substrate on reduction
S Modi, MJ Sutcliffe, WU Primrose, LY Lian, GCK Roberts
Nature structural biology 3 (5), 414-417, 1996
Structure of hen lysozyme in solution
LJ Smith, MJ Sutcliffe, C Redfield, CM Dobson
Journal of molecular biology 229 (4), 930-944, 1993
Analysis of. vphi. and. chi. 1 torsion angles for hen lysozyme in solution from proton NMR spin-spin coupling constants
LJ Smith, MJ Sutcliffe, C Redfield, CM Dobson
Biochemistry 30 (4), 986-996, 1991
Molecular anatomy: phyletic relationships derived from three-dimensional structures of proteins
MS Johnson, MJ Sutcliffe, TL Blundell
Journal of molecular evolution 30 (1), 43-59, 1990
Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6
MJI Paine, LA McLaughlin, JU Flanagan, CA Kemp, MJ Sutcliffe, ...
Journal of Biological Chemistry 278 (6), 4021-4027, 2003
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