Radosław P. Nowak
Radosław P. Nowak
Dana-Farber Cancer Institute
Verified email at crystal.harvard.edu - Homepage
Title
Cited by
Cited by
Year
Plasticity in binding confers selectivity in ligand-induced protein degradation
RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ...
Nature chemical biology 14 (7), 706-714, 2018
1562018
The roles of Jumonji-type oxygenases in human disease
C Johansson, A Tumber, KH Che, P Cain, R Nowak, C Gileadi, ...
Epigenomics 6 (1), 89-120, 2014
1482014
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome
KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ...
Elife 7, e38430, 2018
1402018
Structural analysis of human KDM5B guides histone demethylase inhibitor development
C Johansson, S Velupillai, A Tumber, A Szykowska, ES Hookway, ...
Nature chemical biology 12 (7), 539-545, 2016
1042016
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ...
Nature communications 8 (1), 1-8, 2017
1022017
Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance
W Zhou, AT Whiteley, CC de Oliveira Mann, BR Morehouse, RP Nowak, ...
Cell 174 (2), 300-311. e11, 2018
902018
Homolog-selective degradation as a strategy to probe the function of CDK6 in AML
M Brand, B Jiang, S Bauer, KA Donovan, Y Liang, ES Wang, RP Nowak, ...
Cell chemical biology 26 (2), 300-306. e9, 2019
852019
Chemically induced degradation of anaplastic lymphoma kinase (ALK)
CE Powell, Y Gao, L Tan, KA Donovan, RP Nowak, A Loehr, M Bahcall, ...
Journal of medicinal chemistry 61 (9), 4249-4255, 2018
722018
Potent and selective KDM5 inhibitor stops cellular demethylation of H3K4me3 at transcription start sites and proliferation of MM1S myeloma cells
A Tumber, A Nuzzi, ES Hookway, SB Hatch, S Velupillai, C Johansson, ...
Cell chemical biology 24 (3), 371-380, 2017
622017
Exploring targeted degradation strategy for oncogenic KRASG12C
M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ...
Cell chemical biology 27 (1), 19-31. e6, 2020
522020
Bruton tyrosine kinase degradation as a therapeutic strategy for cancer
D Dobrovolsky, ES Wang, S Morrow, C Leahy, T Faust, RP Nowak, ...
Blood, The Journal of the American Society of Hematology 133 (9), 952-961, 2019
442019
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
TB Faust, H Yoon, RP Nowak, KA Donovan, Z Li, Q Cai, NA Eleuteri, ...
Nature chemical biology 16 (1), 7-14, 2020
432020
Docking and linking of fragments to discover jumonji histone demethylase inhibitors
M Korczynska, DD Le, N Younger, E Gregori-Puigjané, A Tumber, ...
Journal of medicinal chemistry 59 (4), 1580-1598, 2016
402016
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations
M de Wispelaere, G Du, KA Donovan, T Zhang, NA Eleuteri, JC Yuan, ...
Nature communications 10 (1), 1-11, 2019
352019
Development and characterization of a Wee1 kinase degrader
Z Li, BJ Pinch, CM Olson, KA Donovan, RP Nowak, CE Mills, DA Scott, ...
Cell chemical biology 27 (1), 57-65. e9, 2020
242020
Introduction to Structural Studies on 2-Oxoglutarate Dependent Oxygenases and Related Enzymes. in 2-Oxoglutarate-Dependent Oxygenases
WS Aik, R Chowdhury, IJ Clifton, RJ Hopkinson, T Leissing, ...
R. Soc. Chem, 59-94, 2015
242015
Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates
H Tarhonskaya, RP Nowak, C Johansson, A Szykowska, A Tumber, ...
Journal of molecular biology 429 (19), 2895-2906, 2017
212017
An integrated approach to quantitative modelling in angiogenesis research
AJ Connor, RP Nowak, E Lorenzon, M Thomas, F Herting, S Hoert, ...
Journal of The Royal Society Interface 12 (110), 20150546, 2015
212015
Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2
K Morita, S He, RP Nowak, J Wang, MW Zimmerman, C Fu, AD Durbin, ...
Cell 181 (3), 702-715. e20, 2020
202020
Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes
WS Aik, R Chowdhury, IJ Clifton, RJ Hopkinson, T Leissing, ...
2-Oxoglutarate-dependent oxygenases, 59-94, 2015
202015
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