| Plasticity in binding confers selectivity in ligand-induced protein degradation RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ... Nature chemical biology 14 (7), 706-714, 2018 | 156 | 2018 |
| The roles of Jumonji-type oxygenases in human disease C Johansson, A Tumber, KH Che, P Cain, R Nowak, C Gileadi, ... Epigenomics 6 (1), 89-120, 2014 | 148 | 2014 |
| Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ... Elife 7, e38430, 2018 | 140 | 2018 |
| Structural analysis of human KDM5B guides histone demethylase inhibitor development C Johansson, S Velupillai, A Tumber, A Szykowska, ES Hookway, ... Nature chemical biology 12 (7), 539-545, 2016 | 104 | 2016 |
| A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ... Nature communications 8 (1), 1-8, 2017 | 102 | 2017 |
| Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance W Zhou, AT Whiteley, CC de Oliveira Mann, BR Morehouse, RP Nowak, ... Cell 174 (2), 300-311. e11, 2018 | 90 | 2018 |
| Homolog-selective degradation as a strategy to probe the function of CDK6 in AML M Brand, B Jiang, S Bauer, KA Donovan, Y Liang, ES Wang, RP Nowak, ... Cell chemical biology 26 (2), 300-306. e9, 2019 | 85 | 2019 |
| Chemically induced degradation of anaplastic lymphoma kinase (ALK) CE Powell, Y Gao, L Tan, KA Donovan, RP Nowak, A Loehr, M Bahcall, ... Journal of medicinal chemistry 61 (9), 4249-4255, 2018 | 72 | 2018 |
| Potent and selective KDM5 inhibitor stops cellular demethylation of H3K4me3 at transcription start sites and proliferation of MM1S myeloma cells A Tumber, A Nuzzi, ES Hookway, SB Hatch, S Velupillai, C Johansson, ... Cell chemical biology 24 (3), 371-380, 2017 | 62 | 2017 |
| Exploring targeted degradation strategy for oncogenic KRASG12C M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ... Cell chemical biology 27 (1), 19-31. e6, 2020 | 52 | 2020 |
| Bruton tyrosine kinase degradation as a therapeutic strategy for cancer D Dobrovolsky, ES Wang, S Morrow, C Leahy, T Faust, RP Nowak, ... Blood, The Journal of the American Society of Hematology 133 (9), 952-961, 2019 | 44 | 2019 |
| Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 TB Faust, H Yoon, RP Nowak, KA Donovan, Z Li, Q Cai, NA Eleuteri, ... Nature chemical biology 16 (1), 7-14, 2020 | 43 | 2020 |
| Docking and linking of fragments to discover jumonji histone demethylase inhibitors M Korczynska, DD Le, N Younger, E Gregori-Puigjané, A Tumber, ... Journal of medicinal chemistry 59 (4), 1580-1598, 2016 | 40 | 2016 |
| Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations M de Wispelaere, G Du, KA Donovan, T Zhang, NA Eleuteri, JC Yuan, ... Nature communications 10 (1), 1-11, 2019 | 35 | 2019 |
| Development and characterization of a Wee1 kinase degrader Z Li, BJ Pinch, CM Olson, KA Donovan, RP Nowak, CE Mills, DA Scott, ... Cell chemical biology 27 (1), 57-65. e9, 2020 | 24 | 2020 |
| Introduction to Structural Studies on 2-Oxoglutarate Dependent Oxygenases and Related Enzymes. in 2-Oxoglutarate-Dependent Oxygenases WS Aik, R Chowdhury, IJ Clifton, RJ Hopkinson, T Leissing, ... R. Soc. Chem, 59-94, 2015 | 24 | 2015 |
| Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates H Tarhonskaya, RP Nowak, C Johansson, A Szykowska, A Tumber, ... Journal of molecular biology 429 (19), 2895-2906, 2017 | 21 | 2017 |
| An integrated approach to quantitative modelling in angiogenesis research AJ Connor, RP Nowak, E Lorenzon, M Thomas, F Herting, S Hoert, ... Journal of The Royal Society Interface 12 (110), 20150546, 2015 | 21 | 2015 |
| Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2 K Morita, S He, RP Nowak, J Wang, MW Zimmerman, C Fu, AD Durbin, ... Cell 181 (3), 702-715. e20, 2020 | 20 | 2020 |
| Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes WS Aik, R Chowdhury, IJ Clifton, RJ Hopkinson, T Leissing, ... 2-Oxoglutarate-dependent oxygenases, 59-94, 2015 | 20 | 2015 |
Eric S FischerAssociate Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolVerified email at crystal.harvard.edu
