| The roles of Jumonji-type oxygenases in human disease C Johansson, A Tumber, KH Che, P Cain, R Nowak, C Gileadi, ... Epigenomics 6 (1), 89-120, 2014 | 134 | 2014 |
| Plasticity in binding confers selectivity in ligand-induced protein degradation RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ... Nature chemical biology 14 (7), 706-714, 2018 | 95 | 2018 |
| Structural analysis of human KDM5B guides histone demethylase inhibitor development C Johansson, S Velupillai, A Tumber, A Szykowska, ES Hookway, ... Nature chemical biology 12 (7), 539, 2016 | 92 | 2016 |
| Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ... Elife 7, e38430, 2018 | 90 | 2018 |
| A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ... Nature communications 8 (1), 1-8, 2017 | 72 | 2017 |
| Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance W Zhou, AT Whiteley, CC de Oliveira Mann, BR Morehouse, RP Nowak, ... Cell 174 (2), 300-311. e11, 2018 | 59 | 2018 |
| Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML M Brand, B Jiang, S Bauer, KA Donovan, Y Liang, ES Wang, RP Nowak, ... Cell chemical biology 26 (2), 300-306. e9, 2019 | 48 | 2019 |
| Chemically induced degradation of anaplastic lymphoma kinase (ALK) CE Powell, Y Gao, L Tan, KA Donovan, RP Nowak, A Loehr, M Bahcall, ... Journal of medicinal chemistry 61 (9), 4249-4255, 2018 | 47 | 2018 |
| Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells A Tumber, A Nuzzi, ES Hookway, SB Hatch, S Velupillai, C Johansson, ... Cell chemical biology 24 (3), 371-380, 2017 | 46 | 2017 |
| Docking and linking of fragments to discover Jumonji histone demethylase inhibitors M Korczynska, DD Le, N Younger, E Gregori-Puigjané, A Tumber, ... Journal of medicinal chemistry 59 (4), 1580-1598, 2016 | 32 | 2016 |
| Bruton tyrosine kinase degradation as a therapeutic strategy for cancer D Dobrovolsky, ES Wang, S Morrow, C Leahy, T Faust, RP Nowak, ... Blood, The Journal of the American Society of Hematology 133 (9), 952-961, 2019 | 23 | 2019 |
| Exploring Targeted Degradation Strategy for Oncogenic KRASG12C M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ... Cell Chemical Biology 27 (1), 19-31. e6, 2020 | 22 | 2020 |
| Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes. 2-Oxoglutarate-Dependent Oxygenases, eds Hausinger RP, Schofield CJ WS Aik, R Chowdhury, IJ Clifton, RJ Hopkinson, T Leissing, ... R. Soc. Chem, 59-94, 2015 | 21 | 2015 |
| Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 TB Faust, H Yoon, RP Nowak, KA Donovan, Z Li, Q Cai, NA Eleuteri, ... Nature chemical biology 16 (1), 7-14, 2020 | 19 | 2020 |
| Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations M de Wispelaere, G Du, KA Donovan, T Zhang, NA Eleuteri, JC Yuan, ... Nature communications 10 (1), 1-11, 2019 | 19 | 2019 |
| Introduction to Structural Studies on 2-Oxoglutarate-Dependent Oxygenases and Related Enzymes WS Aik, R Chowdhury, IJ Clifton, RJ Hopkinson, T Leissing, ... 2-Oxoglutarate-Dependent Oxygenases, 59-94, 2015 | 19 | 2015 |
| Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates H Tarhonskaya, RP Nowak, C Johansson, A Szykowska, A Tumber, ... Journal of Molecular Biology 429 (19), 2895-2906, 2017 | 18 | 2017 |
| An integrated approach to quantitative modelling in angiogenesis research AJ Connor, RP Nowak, E Lorenzon, M Thomas, F Herting, S Hoert, ... Journal of The Royal Society Interface 12 (110), 20150546, 2015 | 16 | 2015 |
| Advances and challenges in understanding histone demethylase biology RP Nowak, A Tumber, C Johansson, KH Che, P Brennan, D Owen, ... Current Opinion in Chemical Biology 33, 151-159, 2016 | 14 | 2016 |
| Development and Characterization of a Wee1 Kinase Degrader Z Li, BJ Pinch, CM Olson, KA Donovan, RP Nowak, CE Mills, DA Scott, ... Cell Chemical Biology 27 (1), 57-65. e9, 2020 | 9 | 2020 |
Eric S FischerAssociate Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolVerified email at crystal.harvard.edu
