| Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease JH Kordower, ME Emborg, J Bloch, SY Ma, Y Chu, L Leventhal, J McBride, ... Science 290 (5492), 767-773, 2000 | 1520 | 2000 |
| Transvascular delivery of small interfering RNA to the central nervous system P Kumar, H Wu, JL McBride, KE Jung, M Hee Kim, BL Davidson, ... Nature 448 (7149), 39-43, 2007 | 1451 | 2007 |
| Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi JL McBride, RL Boudreau, SQ Harper, PD Staber, AM Monteys, I Martins, ... Proceedings of the National Academy of Sciences 105 (15), 5868-5873, 2008 | 713 | 2008 |
| Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice RL Boudreau, JL McBride, I Martins, S Shen, Y Xing, BJ Carter, ... Molecular Therapy 17 (6), 1053-1063, 2009 | 400 | 2009 |
| Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's … UP Shirendeb, MJ Calkins, M Manczak, V Anekonda, B Dufour, ... Human molecular genetics 21 (2), 406-420, 2012 | 363 | 2012 |
| Human neural stem cell transplants improve motor function in a rat model of Huntington's disease JL McBride, SP Behrstock, EY Chen, RJ Jakel, I Siegel, CN Svendsen, ... Journal of Comparative Neurology 475 (2), 211-219, 2004 | 311 | 2004 |
| Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease JL McBride, MR Pitzer, RL Boudreau, B Dufour, T Hobbs, SR Ojeda, ... Molecular Therapy 19 (12), 2152-2162, 2011 | 303 | 2011 |
| Animal models of Huntington's disease S Ramaswamy, JL McBride, JH Kordower Ilar Journal 48 (4), 356-373, 2007 | 275 | 2007 |
| Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington’s disease JL McBride, S Ramaswamy, M Gasmi, RT Bartus, CD Herzog, ... Proceedings of the National Academy of Sciences 103 (24), 9345-9350, 2006 | 117 | 2006 |
| Structural and functional neuroprotection in a rat model of Huntington’s disease by viral gene transfer of GDNF JL McBride, MJ During, J Wuu, EY Chen, SE Leurgans, JH Kordower Experimental neurology 181 (2), 213-223, 2003 | 114 | 2003 |
| Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia MS Keiser, HB Kordasiewicz, JL McBride Human molecular genetics 25 (R1), R53-R64, 2016 | 113 | 2016 |
| Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses MW Coryell, AM Wunsch, JM Haenfler, JE Allen, JL McBride, BL Davidson, ... Journal of Neuroscience 28 (51), 13738-13741, 2008 | 107 | 2008 |
| AAV-PHP. B administration results in a differential pattern of CNS biodistribution in non-human primates compared with mice WA Liguore, JS Domire, D Button, Y Wang, BD Dufour, S Srinivasan, ... Molecular Therapy 27 (11), 2018-2037, 2019 | 106 | 2019 |
| Intrajugular vein delivery of AAV9-RNAi prevents neuropathological changes and weight loss in Huntington's disease mice BD Dufour, CA Smith, RL Clark, TR Walker, JL McBride Molecular Therapy 22 (4), 797-810, 2014 | 86 | 2014 |
| Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease S Ramaswamy, JL McBride, I Han, EM Berry-Kravis, L Zhou, CD Herzog, ... Neurobiology of disease 34 (1), 40-50, 2009 | 65 | 2009 |
| Intra-striatal AAV2. retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic development AR Weiss, WA Liguore, JS Domire, D Button, JL McBride Scientific reports 10 (1), 6970, 2020 | 55 | 2020 |
| Neuroprotection for Parkinson's disease using viral vector-mediated delivery of GDNF JL McBride, JH Kordower Progress in brain research 138, 421-432, 2002 | 48 | 2002 |
| Single nucleotide seed modification restores in vivo tolerability of a toxic artificial miRNA sequence in the mouse brain AM Monteys, RM Spengler, BD Dufour, MS Wilson, CK Oakley, ... Nucleic acids research 42 (21), 13315-13327, 2014 | 44 | 2014 |
| Reduction of off-target RNA interference toxicity BL Davidson, AM Monteys, JL McBride, R Boudreau US Patent 8,258,286, 2012 | 44 | 2012 |
| Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease S Ramaswamy, JL McBride, CD Herzog, E Brandon, M Gasmi, RT Bartus, ... Neurobiology of disease 26 (2), 375-384, 2007 | 42 | 2007 |
