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Howard Broughton
Howard Broughton
Lilly, S.A.
Verified email at lilly.com
Title
Cited by
Cited by
Year
3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine:  An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 Receptor
JJ Kulagowski, HB Broughton, NR Curtis, IM Mawer, MP Ridgill, R Baker, ...
Journal of medicinal chemistry 39 (10), 1941-1942, 1996
3221996
Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved …
MB van Niel, I Collins, MS Beer, HB Broughton, SKF Cheng, ...
Journal of medicinal chemistry 42 (12), 2087-2104, 1999
2271999
Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition
MS Chambers, JR Atack, HB Broughton, N Collinson, S Cook, ...
Journal of medicinal chemistry 46 (11), 2227-2240, 2003
1932003
Mechanism of inositol monophosphatase, the putative target of lithium therapy.
SJ Pollack, JR Atack, MR Knowles, G McAllister, CI Ragan, R Baker, ...
Proceedings of the National Academy of Sciences 91 (13), 5766-5770, 1994
1791994
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl) piperidin-4-yl) isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors
M Rowley, HB Broughton, I Collins, R Baker, F Emms, R Marwood, ...
Journal of medicinal chemistry 39 (10), 1943-1945, 1996
1571996
Inositol monophosphatase—a putative target for Li+ in the treatment of bipolar disorder
JR Atack, HB Broughton, SJ Pollack
Trends in neurosciences 18 (8), 343-349, 1995
1551995
An X-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
JN Bilton, HB Broughton, PS Jones, SV Ley, HS Rzepa, RN Sheppard, ...
Tetrahedron 43 (12), 2805-2815, 1987
1401987
The chemical basis of serine palmitoyltransferase inhibition by myriocin
JM Wadsworth, DJ Clarke, SA McMahon, JP Lowther, AE Beattie, ...
Journal of the American Chemical Society 135 (38), 14276-14285, 2013
1362013
Selection of heterocycles for drug design
HB Broughton, IA Watson
Journal of Molecular Graphics and Modelling 23 (1), 51-58, 2004
1362004
N-Arylsulfonylindole Derivatives as Serotonin 5-HT6 Receptor Ligands
MGN Russell, RJ Baker, L Barden, MS Beer, L Bristow, HB Broughton, ...
Journal of medicinal chemistry 44 (23), 3881-3895, 2001
1302001
A method for including protein flexibility in protein-ligand docking: improving tools for database mining and virtual screening
HB Broughton
Journal of Molecular Graphics and Modelling 18 (3), 247-257, 2000
1232000
Controlled Modification of Acidity in Cholecystokinin B Receptor Antagonists:  N-(1,4-Benzodiazepin-3-yl)-N ‘-[3-(tetrazol-5-ylamino)phenyl]ureas
JL Castro, RG Ball, HB Broughton, MGN Russell, D Rathbone, AP Watt, ...
Journal of medicinal chemistry 39 (4), 842-849, 1996
1211996
Structure and mechanism of inositol monophosphatase
JR Atack, HB Broughton, SJ Pollack
FEBS letters 361 (1), 1-7, 1995
1191995
X-ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
HB Broughton, SV Ley, AMZ Slawin, DJ Williams, ED Morgan
Journal of the Chemical Society, Chemical Communications, 46-47, 1986
1101986
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor
M Rowley, I Collins, HB Broughton, WB Davey, R Baker, F Emms, ...
Journal of medicinal chemistry 40 (15), 2374-2385, 1997
741997
Two total syntheses of showdomycin and related studies
AGM Barrett, HB Broughton, SV Attwood, AAL Gunatilaka
The Journal of Organic Chemistry 51 (4), 495-503, 1986
701986
The synthesis of Azadirachtin: a potent insect antifeedant
SV Ley, A Abad‐Somovilla, JC Anderson, C Ayats, R Bänteli, ...
Chemistry–A European Journal 14 (34), 10683-10704, 2008
682008
Probing the role of metal ions in the mechanism of inositol monophosphatase by site‐directed mutagenesis
SJ POLLACK, MR KNOWLES, JR ATACK, HB BROUGHTON, CI RAGAN, ...
European journal of biochemistry 217 (1), 281-287, 1993
661993
A residue-resolved Bayesian approach to quantitative interpretation of hydrogen–deuterium exchange from mass spectrometry: application to characterizing protein–ligand interactions
DJ Saltzberg, HB Broughton, R Pellarin, MJ Chalmers, A Espada, ...
The Journal of Physical Chemistry B 121 (15), 3493-3501, 2017
602017
Synthesis of Bioactive Sesterterpenolides from ent-Halimic Acid. 15-Epi-ent-cladocoran A and B
IS Marcos, AB Pedrero, MJ Sexmero, D Diez, P Basabe, N García, ...
The Journal of Organic Chemistry 68 (19), 7496-7504, 2003
532003
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