| 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 Receptor JJ Kulagowski, HB Broughton, NR Curtis, IM Mawer, MP Ridgill, R Baker, ... Journal of medicinal chemistry 39 (10), 1941-1942, 1996 | 323 | 1996 |
| Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved … MB van Niel, I Collins, MS Beer, HB Broughton, SKF Cheng, ... Journal of medicinal chemistry 42 (12), 2087-2104, 1999 | 232 | 1999 |
| Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition MS Chambers, JR Atack, HB Broughton, N Collinson, S Cook, ... Journal of medicinal chemistry 46 (11), 2227-2240, 2003 | 197 | 2003 |
| Mechanism of inositol monophosphatase, the putative target of lithium therapy. SJ Pollack, JR Atack, MR Knowles, G McAllister, CI Ragan, R Baker, ... Proceedings of the National Academy of Sciences 91 (13), 5766-5770, 1994 | 179 | 1994 |
| 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl) piperidin-4-yl) isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors M Rowley, HB Broughton, I Collins, R Baker, F Emms, R Marwood, ... Journal of medicinal chemistry 39 (10), 1943-1945, 1996 | 158 | 1996 |
| Inositol monophosphatase—a putative target for Li+ in the treatment of bipolar disorder JR Atack, HB Broughton, SJ Pollack Trends in neurosciences 18 (8), 343-349, 1995 | 156 | 1995 |
| The chemical basis of serine palmitoyltransferase inhibition by myriocin JM Wadsworth, DJ Clarke, SA McMahon, JP Lowther, AE Beattie, ... Journal of the American Chemical Society 135 (38), 14276-14285, 2013 | 142 | 2013 |
| An X-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives JN Bilton, HB Broughton, PS Jones, SV Ley, HS Rzepa, RN Sheppard, ... Tetrahedron 43 (12), 2805-2815, 1987 | 137 | 1987 |
| Selection of heterocycles for drug design HB Broughton, IA Watson Journal of Molecular Graphics and Modelling 23 (1), 51-58, 2004 | 136 | 2004 |
| N-Arylsulfonylindole Derivatives as Serotonin 5-HT6 Receptor Ligands MGN Russell, RJ Baker, L Barden, MS Beer, L Bristow, HB Broughton, ... Journal of medicinal chemistry 44 (23), 3881-3895, 2001 | 128 | 2001 |
| A method for including protein flexibility in protein-ligand docking: improving tools for database mining and virtual screening HB Broughton Journal of Molecular Graphics and Modelling 18 (3), 247-257, 2000 | 121 | 2000 |
| Controlled Modification of Acidity in Cholecystokinin B Receptor Antagonists: N-(1,4-Benzodiazepin-3-yl)-N ‘-[3-(tetrazol-5-ylamino)phenyl]ureas JL Castro, RG Ball, HB Broughton, MGN Russell, D Rathbone, AP Watt, ... Journal of medicinal chemistry 39 (4), 842-849, 1996 | 119 | 1996 |
| Structure and mechanism of inositol monophosphatase JR Atack, HB Broughton, SJ Pollack FEBS letters 361 (1), 1-7, 1995 | 117 | 1995 |
| X-ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin HB Broughton, SV Ley, AMZ Slawin, DJ Williams, ED Morgan Journal of the Chemical Society, Chemical Communications, 46-47, 1986 | 112 | 1986 |
| 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor M Rowley, I Collins, HB Broughton, WB Davey, R Baker, F Emms, ... Journal of medicinal chemistry 40 (15), 2374-2385, 1997 | 74 | 1997 |
| Two total syntheses of showdomycin and related studies AGM Barrett, HB Broughton, SV Attwood, AAL Gunatilaka The Journal of Organic Chemistry 51 (4), 495-503, 1986 | 70 | 1986 |
| The synthesis of azadirachtin: a potent insect antifeedant SV Ley, A Abad‐Somovilla, JC Anderson, C Ayats, R Bänteli, ... Chemistry–A European Journal 14 (34), 10683-10704, 2008 | 69 | 2008 |
| Probing the role of metal ions in the mechanism of inositol monophosphatase by site‐directed mutagenesis SJ POLLACK, MR KNOWLES, JR ATACK, HB BROUGHTON, CI RAGAN, ... European journal of biochemistry 217 (1), 281-287, 1993 | 66 | 1993 |
| A residue-resolved Bayesian approach to quantitative interpretation of hydrogen–deuterium exchange from mass spectrometry: application to characterizing protein–ligand interactions DJ Saltzberg, HB Broughton, R Pellarin, MJ Chalmers, A Espada, ... The Journal of Physical Chemistry B 121 (15), 3493-3501, 2017 | 61 | 2017 |
| Synthesis of Bioactive Sesterterpenolides from ent-Halimic Acid. 15-Epi-ent-cladocoran A and B IS Marcos, AB Pedrero, MJ Sexmero, D Diez, P Basabe, N García, ... The Journal of Organic Chemistry 68 (19), 7496-7504, 2003 | 54 | 2003 |
