Hanna Tarhonskaya
Hanna Tarhonskaya
University of Oxford, Chemistry Research Laboratory
Verified email at chem.ox.ac.uk
Title
Cited by
Cited by
Year
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
H Tarhonskaya, AM Rydzik, IKH Leung, ND Loik, MC Chan, A Kawamura, ...
Nature communications 5 (1), 1-10, 2014
542014
Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase
EM Sánchez-Fernández, H Tarhonskaya, K Al-Qahtani, RJ Hopkinson, ...
Biochemical Journal 449 (2), 491-496, 2013
492013
Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability
A Makena, J Brem, I Pfeffer, REJ Geffen, SE Wilkins, H Tarhonskaya, ...
Journal of Antimicrobial Chemotherapy 70 (2), 463-469, 2015
442015
Kinetic investigations of the role of factor inhibiting hypoxia-inducible factor (FIH) as an oxygen sensor
H Tarhonskaya, AP Hardy, EA Howe, ND Loik, HB Kramer, ...
Journal of Biological Chemistry 290 (32), 19726-19742, 2015
392015
Studying the active-site loop movement of the Săo Paolo metallo-β-lactamase-1
J Brem, WB Struwe, AM Rydzik, H Tarhonskaya, I Pfeffer, E Flashman, ...
Chemical science 6 (2), 956-963, 2015
372015
Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
H Tarhonskaya, R Chowdhury, IKH Leung, ND Loik, JSO McCullagh, ...
Biochemical Journal 463 (3), 363-372, 2014
332014
Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases
H Tarhonskaya, A Szöllössi, IKH Leung, JT Bush, L Henry, ...
Biochemistry 53 (15), 2483-2493, 2014
292014
Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases
CC Thinnes, A Tumber, C Yapp, G Scozzafava, T Yeh, MC Chan, TA Tran, ...
Chemical Communications 51 (84), 15458-15461, 2015
282015
Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication
IP Foskolou, C Jorgensen, KB Leszczynska, MM Olcina, H Tarhonskaya, ...
Molecular cell 66 (2), 206-220. e9, 2017
272017
Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates
H Tarhonskaya, RP Nowak, C Johansson, A Szykowska, A Tumber, ...
Journal of molecular biology 429 (19), 2895-2906, 2017
182017
Structure and mechanism of a viral collagen prolyl hydroxylase
JE Longbotham, C Levy, LO Johannissen, H Tarhonskaya, S Jiang, ...
Biochemistry 54 (39), 6093-6105, 2015
132015
Use of ferrous iron by metallo-β-lactamases
ST Cahill, H Tarhonskaya, AM Rydzik, E Flashman, MA McDonough, ...
Journal of inorganic biochemistry 163, 185-193, 2016
112016
The clinically used iron chelator deferasirox is an inhibitor of epigenetic JumonjiC domain-containing histone demethylases
M Roatsch, I Hoffmann, MI Abboud, RL Hancock, H Tarhonskaya, KF Hsu, ...
ACS chemical biology 14 (8), 1737-1750, 2019
92019
YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase
SE Wilkins, J Bush, H Tarhonskaya, M Münzel, A Hussein, E Flashman, ...
Extremophiles 22 (3), 553-562, 2018
42018
Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1‐Dichloromethylinden‐1‐ol Analogues
L Guillade, F Sarno, H Tarhonskaya, A Nebbioso, S Alvarez, A Kawamura, ...
ChemMedChem 13 (18), 1949-1956, 2018
32018
In Vitro Enzyme Assays for JmjC‐Domain‐Containing Lysine Histone Demethylases (JmjC‐KDMs)
H Tarhonskaya, A Tumber, A Kawamura, CJ Schofield
Current protocols in pharmacology 80 (1), 3.15. 1-3.15. 12, 2018
22018
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens
K Lippl, A Boleininger, MA McDonough, MI Abboud, H Tarhonskaya, ...
Hypoxia 6, 57, 2018
22018
The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases
M Jung, M Roatsch, I Hoffmann, MI Abboud, RL Hancock, H Tarhonskaya, ...
2019
Kinetic and mechanistic studies of oxygen sensing Fe (II)/2-oxoglutarate dependent oxygenases
H Tarhonskaya
University of Oxford, 2014
2014
Kinetic investigations on the reaction of a 2-oxoglutarate dependent histone demethylase with oxygen
EM Sanchez-Fernandez, H Tarhonskaya, K Al-Qahtani, J Hopkinson, ...
FEBS JOURNAL 279, 2012
2012
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