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Matthew D Cheeseman
Matthew D Cheeseman
Other namesMatt Cheeseman
The ARUK UCL DDI
Verified email at ucl.ac.uk
Title
Cited by
Cited by
Year
Lysine‐targeting covalent inhibitors
J Pettinger, K Jones, MD Cheeseman
Angewandte Chemie International Edition 56 (48), 15200-15209, 2017
1792017
Demonstrating in-cell target engagement using a pirin protein degradation probe (CCT367766)
NEA Chessum, SY Sharp, JJ Caldwell, AE Pasqua, B Wilding, ...
Journal of medicinal chemistry 61 (3), 918-933, 2018
902018
Flexible strategy for the synthesis of pyrrolizidine alkaloids
TJ Donohoe, RE Thomas, MD Cheeseman, CL Rigby, G Bhalay, ...
Organic letters 10 (16), 3615-3618, 2008
742008
An irreversible inhibitor of HSP72 that unexpectedly targets lysine‐56
J Pettinger, YV Le Bihan, M Widya, RLM van Montfort, K Jones, ...
Angewandte Chemie 129 (13), 3590-3594, 2017
652017
Discovery of a chemical probe bisamide (CCT251236): an orally bioavailable efficacious pirin ligand from a heat shock transcription factor 1 (HSF1) phenotypic screen
MD Cheeseman, NEA Chessum, CS Rye, AE Pasqua, MJ Tucker, ...
Journal of medicinal chemistry 60 (1), 180-201, 2017
502017
Kinetic optimization of lysine-targeting covalent inhibitors of HSP72
J Pettinger, M Carter, K Jones, MD Cheeseman
Journal of Medicinal Chemistry 62 (24), 11383-11398, 2019
432019
Exploiting protein conformational change to optimize adenosine-derived inhibitors of HSP70
MD Cheeseman, IM Westwood, O Barbeau, M Rowlands, S Dobson, ...
Journal of Medicinal Chemistry 59 (10), 4625-4636, 2016
362016
An efficient asymmetric synthesis of grenadamide
R Green, M Cheeseman, S Duffill, A Merritt, SD Bull
Tetrahedron letters 46 (46), 7931-7934, 2005
342005
An efficient synthesis of semiplenamide C
IR Davies, M Cheeseman, DG Niyadurupola, SD Bull
Tetrahedron letters 46 (33), 5547-5549, 2005
322005
N–N Bond-Forming Cyclization for the One-Pot Synthesis of N-Aryl[3,4-d]pyrazolopyrimidines
LE Evans, MD Cheeseman, K Jones
Organic letters 14 (13), 3546-3549, 2012
312012
Multicatalytic enantioselective borrowing hydrogen δ-lactonization strategy from β-keto esters and allylic alcohols
A Quintard, M Roudier, J Rodriguez
Synthesis 50 (04), 785-792, 2018
282018
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms
AM Jones, IM Westwood, JD Osborne, TP Matthews, MD Cheeseman, ...
Scientific reports 6 (1), 34701, 2016
272016
A temporary stereocentre approach for the asymmetric synthesis of chiral cyclopropane-carboxaldehydes
M Cheeseman, IR Davies, P Axe, AL Johnson, SD Bull
Organic & Biomolecular Chemistry 7 (17), 3537-3548, 2009
272009
Investigating apoptozole as a chemical probe for HSP70 inhibition
LE Evans, MD Cheeseman, N Yahya, K Jones
PLoS One 10 (10), e0140006, 2015
262015
Synthesis of (+)-DGDP and (−)-7-epialexine
TJC áO'Riordan
Organic & Biomolecular Chemistry 6 (21), 3896-3898, 2008
242008
Discovery of 4, 6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9
CS Rye, NEA Chessum, S Lamont, KG Pike, P Faulder, J Demeritt, ...
Medchemcomm 7 (8), 1580-1586, 2016
232016
Efficient asymmetric synthesis of chiral hydroxy-γ-butyrolactones
IR Davies, M Cheeseman, R Green, MF Mahon, A Merritt, SD Bull
Organic Letters 11 (13), 2896-2899, 2009
232009
Stereoselective synthesis of (E)-trisubstituted α, β-unsaturated amides and acids
FJP Feuillet, M Cheeseman, MF Mahon, SD Bull
Organic & Biomolecular Chemistry 3 (16), 2976-2989, 2005
232005
Asymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocenters
J Peed, I Periñán Domínguez, IR Davies, M Cheeseman, JE Taylor, ...
Organic Letters 13 (14), 3592-3595, 2011
202011
Privileged structures and polypharmacology within and between protein families
J Meyers, NEA Chessum, S Ali, NY Mok, B Wilding, AE Pasqua, ...
ACS Medicinal Chemistry Letters 9 (12), 1199-1204, 2018
192018
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