David Borchelt
David Borchelt
Professor of Neuroscience, University of Florida
Verified email at
Cited by
Cited by
Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo
DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ...
Neuron 17 (5), 1005-1013, 1996
APP processing and synaptic function
F Kamenetz, T Tomita, H Hsieh, G Seabrook, D Borchelt, T Iwatsubo, ...
Neuron 37 (6), 925-937, 2003
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
PC Wong, CA Pardo, DR Borchelt, MK Lee, NG Copeland, NA Jenkins, ...
Neuron 14 (6), 1105-1116, 1995
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
LI Bruijn, MW Becher, MK Lee, KL Anderson, NA Jenkins, NG Copeland, ...
Neuron 18 (2), 327-338, 1997
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
JL Jankowsky, DJ Fadale, J Anderson, GM Xu, V Gonzales, NA Jenkins, ...
Human molecular genetics 13 (2), 159-170, 2004
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
H Cai, Y Wang, D McCarthy, H Wen, DR Borchelt, DL Price, PC Wong
Nature neuroscience 4 (3), 233-234, 2001
Scrapie prion protein contains a phosphatidylinositol glycolipid
N Stahl, DR Borchelt, K Hsiao, SB Prusiner
Cell 51 (2), 229-240, 1987
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
G Thinakaran, DR Borchelt, MK Lee, HH Slunt, L Spitzer, G Kim, ...
Neuron 17 (1), 181-190, 1996
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
DR Borchelt, T Ratovitski, J Van Lare, MK Lee, V Gonzales, NA Jenkins, ...
Neuron 19 (4), 939-945, 1997
Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide
D Krewski, RA Yokel, E Nieboer, D Borchelt, J Cohen, J Harry, S Kacew, ...
Journal of Toxicology and Environmental Health, Part B 10 (S1), 1-269, 2007
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
G Schilling, MW Becher, AH Sharp, HA Jinnah, K Duan, JA Kotzuk, ...
Human molecular genetics 8 (3), 397-407, 1999
Decreased expression of striatal signaling genes in a mouse model of Huntington’s disease
R Luthi-Carter, A Strand, NL Peters, SM Solano, ZR Hollingsworth, ...
Human molecular genetics 9 (9), 1259-1271, 2000
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
JL Jankowsky, HH Slunt, T Ratovitski, NA Jenkins, NG Copeland, ...
Biomolecular engineering 17 (6), 157-165, 2001
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.
DR Borchelt, MK Lee, HS Slunt, M Guarnieri, ZS Xu, PC Wong, ...
Proceedings of the National Academy of Sciences 91 (17), 8292-8296, 1994
Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.
DR Borchelt, M Scott, A Taraboulos, N Stahl, SB Prusiner
The Journal of cell biology 110 (3), 743-752, 1990
Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins
KK Hsiao, DR Borchelt, K Olson, R Johannsdottir, C Kitt, W Yunis, S Xu, ...
Neuron 15 (5), 1203-1218, 1995
Evidence for synthesis of scrapie prion proteins in the endocytic pathway.
DR Borchelt, A Taraboulos, SB Prusiner
Journal of Biological Chemistry 267 (23), 16188-16199, 1992
BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
FM Laird, H Cai, AV Savonenko, MH Farah, K He, T Melnikova, H Wen, ...
Journal of Neuroscience 25 (50), 11693-11709, 2005
Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease
JL Jankowsky, T Melnikova, DJ Fadale, GM Xu, HH Slunt, V Gonzales, ...
Journal of Neuroscience 25 (21), 5217-5224, 2005
Alzheimer's disease: genetic studies and transgenic models
DL Price, RE Tanzi, DR Borchelt, SS Sisodia
Annual review of genetics 32, 461, 1998
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