Kilian V. M. Huber
Kilian V. M. Huber
Principal Investigator, University of Oxford
Verified email at cmd.ox.ac.uk - Homepage
Title
Cited by
Cited by
Year
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
4882015
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
M Rebsamen, L Pochini, T Stasyk, MEG de Araújo, M Galluccio, ...
Nature 519 (7544), 477-481, 2015
4092015
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers
L Brault, C Gasser, F Bracher, K Huber, S Knapp, J Schwaller
haematologica 95 (6), 1004-1015, 2010
3202010
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
KVM Huber, E Salah, B Radic, M Gridling, JM Elkins, A Stukalov, ...
Nature 508 (7495), 222-227, 2014
3122014
Artemisinins target GABAA receptor signaling and impair α cell identity
J Li, T Casteels, T Frogne, C Ingvorsen, C Honore, M Courtney, ...
Cell 168 (1-2), 86-100. e15, 2017
2022017
Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing
O Fedorov, K Huber, A Eisenreich, P Filippakopoulos, O King, AN Bullock, ...
Chemistry & biology 18 (1), 67-76, 2011
1632011
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
F Grebien, M Vedadi, M Getlik, R Giambruno, A Grover, R Avellino, ...
Nature chemical biology 11 (8), 571-578, 2015
1362015
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity
GE Winter, B Radic, C Mayor-Ruiz, VA Blomen, C Trefzer, RK Kandasamy, ...
Nature chemical biology 10 (9), 768-773, 2014
1202014
Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling
KVM Huber, KM Olek, AC Müller, CSH Tan, KL Bennett, J Colinge, ...
Nature methods 12 (11), 1055-1057, 2015
1102015
A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis
A Fauster, M Rebsamen, KVM Huber, JW Bigenzahn, A Stukalov, ...
Cell death & disease 6 (5), e1767-e1767, 2015
1012015
Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action
MV Babak, SM Meier, KVM Huber, J Reynisson, AA Legin, MA Jakupec, ...
Chemical science 6 (4), 2449-2456, 2015
892015
Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma
U Weirauch, N Beckmann, M Thomas, A Grünweller, K Huber, F Bracher, ...
Neoplasia 15 (7), 783-IN28, 2013
752013
Novel 3-Arylideneindolin-2-ones as Inhibitors of NAD+-Dependent Histone Deacetylases (Sirtuins)
K Huber, J Schemies, U Uciechowska, JM Wagner, T Rumpf, F Lewrick, ...
Journal of medicinal chemistry 53 (3), 1383-1386, 2010
682010
7, 8-Dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes
K Huber, L Brault, O Fedorov, C Gasser, P Filippakopoulos, AN Bullock, ...
Journal of medicinal chemistry 55 (1), 403-413, 2012
642012
Quantitative, wide-spectrum kinase profiling in live cells for assessing the effect of cellular ATP on target engagement
JD Vasta, CR Corona, J Wilkinson, CA Zimprich, JR Hartnett, MR Ingold, ...
Cell chemical biology 25 (2), 206-214. e11, 2018
632018
Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions
R Martins, J Maier, AD Gorki, KVM Huber, O Sharif, P Starkl, S Saluzzo, ...
Nature Immunology 17 (12), 1361-1372, 2016
592016
Discovery of a PCAF bromodomain chemical probe
M Moustakim, PGK Clark, L Trulli, AL Fuentes de Arriba, MT Ehebauer, ...
Angewandte Chemie 129 (3), 845-849, 2017
562017
Designing multi-target drugs
M Shahid, J Hornberg, G Superti-Furga, M Young, M Keiser, J Mason, ...
Royal Society of Chemistry, 2012
562012
After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders
K Huber, G Superti-Furga
Bioorganic & medicinal chemistry 19 (12), 3616-3624, 2011
542011
Nilotinib exerts direct pro-atherogenic and anti-angiogenic effects on vascular endothelial cells: a potential explanation for drug-induced vasculopathy in CML
H Emir, K Albrecht-Schgoer, K Huber, F Grebien, G Eisenwort, W Schgoer, ...
Blood, The Journal of the American Society of Hematology 122 (21), 257-257, 2013
532013
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