| An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor CA Opitz, UM Litzenburger, F Sahm, M Ott, I Tritschler, S Trump, ... Nature 478 (7368), 197-203, 2011 | 1919 | 2011 |
| Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond M Platten, EAA Nollen, UF Röhrig, F Fallarino, CA Opitz Nature reviews Drug discovery 18 (5), 379-401, 2019 | 1068 | 2019 |
| Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts I Makarenko, CA Opitz, MC Leake, C Neagoe, M Kulke, JK Gwathmey, ... Circulation research 95 (7), 708-716, 2004 | 426 | 2004 |
| Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2, 3-dioxygenase-1 via … CA Opitz, UM Litzenburger, C Lutz, TV Lanz, I Tritschler, A Köppel, ... Stem cells 27 (4), 909-919, 2009 | 400 | 2009 |
| Isoform diversity of giant proteins in relation to passive and active contractile properties of rabbit skeletal muscles LG Prado, I Makarenko, C Andresen, M Krüger, CA Opitz, WA Linke The Journal of general physiology 126 (5), 461-480, 2005 | 382 | 2005 |
| IL4I1 is a metabolic immune checkpoint that activates the AHR and promotes tumor progression A Sadik, LFS Patterson, S Öztürk, SR Mohapatra, V Panitz, PF Secker, ... Cell 182 (5), 1252-1270. e34, 2020 | 366 | 2020 |
| Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR UM Litzenburger, CA Opitz, F Sahm, KJ Rauschenbach, S Trump, ... Oncotarget 5 (4), 1038, 2014 | 321 | 2014 |
| Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness C Neagoe, CA Opitz, I Makarenko, WA Linke Journal of Muscle Research & Cell Motility 24 (2), 175-189, 2003 | 256 | 2003 |
| Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart CA Opitz, MC Leake, I Makarenko, V Benes, WA Linke Circulation research 94 (7), 967-975, 2004 | 228 | 2004 |
| The therapeutic potential of targeting tryptophan catabolism in cancer CA Opitz, LF Somarribas Patterson, SR Mohapatra, DL Dewi, A Sadik, ... British journal of cancer 122 (1), 30-44, 2020 | 212 | 2020 |
| The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress F Sahm, I Oezen, CA Opitz, B Radlwimmer, A Von Deimling, T Ahrendt, ... Cancer research 73 (11), 3225-3234, 2013 | 190 | 2013 |
| The indoleamine-2, 3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells CA Opitz, UM Litzenburger, U Opitz, F Sahm, K Ochs, C Lutz, W Wick, ... PloS one 6 (5), e19823, 2011 | 179 | 2011 |
| Damped elastic recoil of the titin spring in myofibrils of human myocardium CA Opitz, M Kulke, MC Leake, C Neagoe, H Hinssen, RJ Hajjar, WA Linke Proceedings of the National Academy of Sciences 100 (22), 12688-12693, 2003 | 162 | 2003 |
| Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas K Aslan, V Turco, J Blobner, JK Sonner, AR Liuzzi, NG Núñez, D De Feo, ... Nature communications 11 (1), 931, 2020 | 146 | 2020 |
| Tryptophan degradation in autoimmune diseases CA Opitz, W Wick, L Steinman, M Platten Cellular and Molecular Life Sciences 64, 2542-2563, 2007 | 114 | 2007 |
| Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma K Ochs, F Sahm, CA Opitz, TV Lanz, I Oezen, PO Couraud, ... Journal of neuroimmunology 265 (1-2), 106-116, 2013 | 109 | 2013 |
| G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling MT Prentzell, U Rehbein, MC Sandoval, AS De Meulemeester, ... Cell 184 (3), 655-674. e27, 2021 | 93 | 2021 |
| Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology JK Sonner, M Keil, M Falk-Paulsen, N Mishra, A Rehman, M Kramer, ... Nature communications 10 (1), 4877, 2019 | 89 | 2019 |
| Pirfenidone inhibits TGF-β expression in malignant glioma cells I Burghardt, F Tritschler, CA Opitz, B Frank, M Weller, W Wick Biochemical and biophysical research communications 354 (2), 542-547, 2007 | 82 | 2007 |
| The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner AM Heberle, PR Navas, M Langelaar-Makkinje, K Kasack, A Sadik, ... Life science alliance 2 (2), 2019 | 72 | 2019 |
Wolfgang A LinkeProfessor of Physiology, University of MünsterVerified email at uni-muenster.de
