Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis J Kennedy, K Auclair, SG Kendrew, C Park, JC Vederas, CR Hutchinson Science 284 (5418), 1368-1372, 1999 | 852 | 1999 |
Lovastatin nonaketide synthase catalyzes an intramolecular Diels-Alder reaction of a substrate analogue K Auclair, A Sutherland, J Kennedy, DJ Witter, JP Van den Heever, ... Journal of the American Chemical Society 122 (46), 11519-11520, 2000 | 334 | 2000 |
Marine metagenomics: strategies for the discovery of novel enzymes with biotechnological applications from marine environments J Kennedy, JR Marchesi, ADW Dobson Microb Cell Fact 7 (1), 27, 2008 | 273 | 2008 |
Isolation and analysis of bacteria with antimicrobial activities from the marine sponge Haliclona simulans collected from Irish waters J Kennedy, P Baker, C Piper, PD Cotter, M Walsh, MJ Mooij, MB Bourke, ... Marine Biotechnology 11 (3), 384-396, 2009 | 263 | 2009 |
Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides A Schirmer, J Kennedy, S Murli, R Reid, DV Santi Proceedings of the National Academy of Sciences of the United States of …, 2006 | 218 | 2006 |
Production of the antitumor drug epirubicin (4′-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius K Madduri, J Kennedy, G Rivola, A Inventi-Solari, S Filippini, G Zanuso, ... Nature biotechnology 16 (1), 69-74, 1998 | 218 | 1998 |
Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism J Kennedy, B Flemer, SA Jackson, DPH Lejon, JP Morrissey, F O’Gara, ... Marine drugs 8 (3), 608-628, 2010 | 206 | 2010 |
Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products J Kennedy Natural product reports 25 (1), 25-34, 2008 | 192 | 2008 |
Heterologous production of epothilone C and D in Escherichia coli SC Mutka, JR Carney, Y Liu, J Kennedy Biochemistry 45 (4), 1321-1330, 2006 | 188 | 2006 |
Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production S Murli, J Kennedy, LC Dayem, JR Carney, JT Kealey Journal of Industrial Microbiology and Biotechnology 30 (8), 500-509, 2003 | 177 | 2003 |
Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases CR Hutchinson, J Kennedy, C Park, S Kendrew, K Auclair, J Vederas Antonie Van Leeuwenhoek 78 (3), 287-295, 2000 | 167 | 2000 |
Functional metagenomic strategies for the discovery of novel enzymes and biosurfactants with biotechnological applications from marine ecosystems J Kennedy, ND O’Leary, GS Kiran, JP Morrissey, F O’Gara, J Selvin, ... Journal of applied microbiology 111 (4), 787-799, 2011 | 166 | 2011 |
Metagenomic approaches to exploit the biotechnological potential of the microbial consortia of marine sponges J Kennedy, JR Marchesi, ADW Dobson Applied microbiology and biotechnology 75 (1), 11-20, 2007 | 148 | 2007 |
δ-(L-α-Aminoadipyl)-L-cysteinyl-D-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans J Kennedy, G Turner Molecular and General Genetics MGG 253 (1), 189-197, 1996 | 126 | 1996 |
Diversity of microbes associated with the marine sponge, Haliclona simulans, isolated from Irish waters and identification of polyketide synthase genes from the sponge metagenome J Kennedy, CE Codling, BV Jones, ADW Dobson, JR Marchesi Environmental microbiology 10 (7), 1888-1902, 2008 | 120 | 2008 |
Isolation identification and biochemical characterization of a novel halo-tolerant lipase from the metagenome of the marine sponge Haliclona simulans J Selvin, J Kennedy, DPH Lejon, GS Kiran, ADW Dobson Microb Cell Fact 11 (1), 72, 2012 | 103 | 2012 |
Diversity and antimicrobial activities of microbes from two Irish marine sponges, Suberites carnosus and Leucosolenia sp. B Flemer, J Kennedy, LM Margassery, JP Morrissey, F O’Gara, ... Journal of applied microbiology 112 (2), 289-301, 2012 | 96 | 2012 |
Pyrosequencing reveals diverse and distinct sponge-specific microbial communities in sponges from a single geographical location in Irish waters SA Jackson, J Kennedy, JP Morrissey, F O’Gara, ADW Dobson Microbial ecology 64 (1), 105-116, 2012 | 89 | 2012 |
Evidence of a putative deep sea specific microbiome in marine sponges J Kennedy, B Flemer, SA Jackson, JP Morrissey, F O'Gara, ADW Dobson PloS one 9 (3), e91092, 2014 | 86 | 2014 |
Phylogenetic diversity and antimicrobial activities of fungi associated with Haliclona simulans isolated from Irish coastal waters PW Baker, J Kennedy, ADW Dobson, JR Marchesi Marine Biotechnology 11 (4), 540-547, 2009 | 81 | 2009 |