Martin D Ryan
Martin D Ryan
Professor of Translational Virology, University of St Andrews
Verified email at - Homepage
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Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’
MLL Donnelly, G Luke, A Mehrotra, X Li, LE Hughes, D Gani, MD Ryan
Journal of General Virology 82 (5), 1013-1025, 2001
The ‘cleavage’activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring ‘2A-like’sequences
MLL Donnelly, LE Hughes, G Luke, H Mendoza, E Ten Dam, D Gani, ...
Journal of General Virology 82 (5), 1027-1041, 2001
Cleavage of foot-and-mouth disease virus polyprotein is mediated by residues located within a 19 amino acid sequence
MD Ryan, AMQ King, GP Thomas
Journal of General Virology 72 (11), 2727-2732, 1991
Foot‐and‐mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein.
MD Ryan, J Drew
The EMBO journal 13 (4), 928-933, 1994
E unum pluribus: multiple proteins from a self-processing polyprotein
P De Felipe, GA Luke, LE Hughes, D Gani, C Halpin, MD Ryan
Trends in biotechnology 24 (2), 68-75, 2006
Virus-encoded proteinases of the picornavirus super-group
MD Ryan, M Flint
Journal of General Virology 78 (4), 699-723, 1997
Differentiating infection from vaccination in foot-and-mouth disease using a panel of recombinant, non-structural proteins in ELISA
DKJ Mackay, MA Forsyth, PR Davies, A Berlinzani, GJ Belsham, M Flint, ...
Vaccine 16 (5), 446-459, 1998
The cleavage activities of aphthovirus and cardiovirus 2A proteins.
MLL Donnelly, D Gani, M Flint, S Monaghan, MD Ryan
Journal of General Virology 78 (1), 13-21, 1997
Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide
P de Felipe, LE Hughes, MD Ryan, JD Brown
Journal of Biological Chemistry 278 (13), 11441-11448, 2003
Site-specific release of nascent chains from ribosomes at a sense codon
VA Doronina, C Wu, P De Felipe, MS Sachs, MD Ryan, JD Brown
Molecular and cellular biology 28 (13), 4227-4239, 2008
Self‐processing 2A‐polyproteins–a system for co‐ordinate expression of multiple proteins in transgenic plants
C Halpin, SE Cooke, A Barakate, AE Amrani, MD Ryan
The Plant Journal 17 (4), 453-459, 1999
RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies
F Tulloch, NJ Atkinson, DJ Evans, MD Ryan, P Simmonds
elife 3, e04531, 2014
Occurrence, function and evolutionary origins of ‘2A-like’sequences in virus genomes
GA Luke, P De Felipe, A Lukashev, SE Kallioinen, EA Bruno, MD Ryan
Journal of General Virology 89 (4), 1036-1042, 2008
Effects of foot-and-mouth disease virus nonstructural proteins on the structure and function of the early secretory pathway: 2BC but not 3A blocks endoplasmic reticulum-to …
K Moffat, G Howell, C Knox, GJ Belsham, P Monaghan, MD Ryan, ...
Journal of virology 79 (7), 4382-4395, 2005
2A peptides provide distinct solutions to driving stop-carry on translational recoding
P Sharma, F Yan, VA Doronina, H Escuin-Ordinas, MD Ryan, JD Brown
Nucleic acids research 40 (7), 3143-3151, 2012
Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing
MD Ryan, GJ Belsham, AMQ King
Virology 173 (1), 35-45, 1989
A case for “StopGo”: reprogramming translation to augment codon meaning of GGN by promoting unconventional termination (Stop) after addition of glycine and then allowing …
JF Atkins, NM Wills, G Loughran, CY Wu, K Parsawar, MD Ryan, ...
Rna 13 (6), 803-810, 2007
Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapy
P de Felipe, V Martin, ML Cortes, M Ryan, M Izquierdo
Gene therapy 6 (2), 198-208, 1999
Targeting of proteins derived from self‐processing polyproteins containing multiple signal sequences
P De Felipe, MD Ryan
Traffic 5 (8), 616-626, 2004
Inhibition of the secretory pathway by foot-and-mouth disease virus 2BC protein is reproduced by coexpression of 2B with 2C, and the site of inhibition is determined by the …
K Moffat, C Knox, G Howell, SJ Clark, H Yang, GJ Belsham, M Ryan, ...
Journal of virology 81 (3), 1129-1139, 2007
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