John D Hayes
John D Hayes
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Cited by
Cited by
Glutathione transferases
JD Hayes, JU Flanagan, IR Jowsey
Annu. Rev. Pharmacol. Toxicol. 45, 51-88, 2005
The glut athione S-transferase supergene family: regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part II
JD Hayes, DJ Pulford
Critical reviews in biochemistry and molecular biology 30 (6), 521-600, 1995
Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
JD Hayes, LI McLellan
Free radical research 31 (4), 273-300, 1999
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
JD Hayes, AT Dinkova-Kostova
Trends in biochemical sciences 39 (4), 199-218, 2014
Oxidative stress in cancer
JD Hayes, AT Dinkova-Kostova, KD Tew
Cancer cell 38 (2), 167-197, 2020
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
A Jain, T Lamark, E Sjøttem, KB Larsen, JA Awuh, A Øvervatn, ...
Journal of biological chemistry 285 (29), 22576-22591, 2010
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
M McMahon, K Itoh, M Yamamoto, JD Hayes
Journal of Biological Chemistry 278 (24), 21592-21600, 2003
Glutathione S-transferase polymorphisms and their biological consequences
JD Hayes, RC Strange
Pharmacology 61 (3), 154-166, 2000
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
JD Hayes, M McMahon
Trends in biochemical sciences 34 (4), 176-188, 2009
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
A Cuadrado, AI Rojo, G Wells, JD Hayes, SP Cousin, WL Rumsey, ...
Nature reviews Drug discovery 18 (4), 295-317, 2019
Nomenclature for human glutathione transferases.
B Mannervik, YC Awasthi, PG Board, JD Hayes, C Di Ilio, B Ketterer, ...
Biochemical Journal 282 (Pt 1), 305, 1992
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
LE Tebay, H Robertson, ST Durant, SR Vitale, TM Penning, ...
Free Radical Biology and Medicine 88, 108-146, 2015
The Cap ‘n’Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification …
M McMahon, K Itoh, M Yamamoto, SA Chanas, CJ Henderson, ...
Cancer research 61 (8), 3299-3307, 2001
SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
P Rada, AI Rojo, S Chowdhry, M McMahon, JD Hayes, A Cuadrado
Molecular and cellular biology, 2011
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines
C Bonnesen, IM Eggleston, JD Hayes
Cancer research 61 (16), 6120-6130, 2001
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
S Chowdhry, Y Zhang, M McMahon, C Sutherland, A Cuadrado, ...
Oncogene 32 (32), 3765-3781, 2013
Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway
JD Hayes, M McMahon, S Chowdhry, AT Dinkova-Kostova
Antioxidants & redox signaling 13 (11), 1713-1748, 2010
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD (P) H: quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence
P Nioi, M McMahon, K Itoh, M Yamamoto, JD Hayes
Biochemical Journal 374 (2), 337-348, 2003
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a “tethering” mechanism: a two-site interaction model for the Nrf2-Keap1 complex
M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes
Journal of Biological Chemistry 281 (34), 24756-24768, 2006
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron
M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes
Journal of Biological Chemistry 279 (30), 31556-31567, 2004
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