| Mapping the degradable kinome provides a resource for expedited degrader development KA Donovan, FM Ferguson, JW Bushman, NA Eleuteri, D Bhunia, SS Ryu, ... Cell 183 (6), 1714-1731. e10, 2020 | 170 | 2020 |
| Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 TB Faust, H Yoon, RP Nowak, KA Donovan, Z Li, Q Cai, NA Eleuteri, ... Nature chemical biology 16 (1), 7-14, 2020 | 156 | 2020 |
| Bruton tyrosine kinase degradation as a therapeutic strategy for cancer D Dobrovolsky, ES Wang, S Morrow, C Leahy, T Faust, RP Nowak, ... Blood, The Journal of the American Society of Hematology 133 (9), 952-961, 2019 | 143 | 2019 |
| Development and characterization of a Wee1 kinase degrader Z Li, BJ Pinch, CM Olson, KA Donovan, RP Nowak, CE Mills, DA Scott, ... Cell chemical biology 27 (1), 57-65. e9, 2020 | 76 | 2020 |
| Exploring the target scope of KEAP1 E3 ligase-based PROTACs G Du, J Jiang, NJ Henning, N Safaee, E Koide, RP Nowak, KA Donovan, ... Cell chemical biology 29 (10), 1470-1481. e31, 2022 | 37 | 2022 |
| Rewiring cancer drivers to activate apoptosis S Gourisankar, A Krokhotin, W Ji, X Liu, CY Chang, SH Kim, Z Li, ... Nature 620 (7973), 417-425, 2023 | 32 | 2023 |
| A Concise Stereocontrolled Total Synthesis of (±)‐Stemoamide Z Li, L Zhang, FG Qiu Asian Journal of Organic Chemistry 3 (1), 52-54, 2014 | 20 | 2014 |
| Identification of small molecule inhibitors targeting the Zika virus envelope protein J Pitts, CY Hsia, W Lian, J Wang, MP Pfeil, N Kwiatkowski, Z Li, J Jang, ... Antiviral research 164, 147-153, 2019 | 14 | 2019 |
| Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC TW Gero, DE Heppner, TS Beyett, C To, SC Azevedo, J Jang, T Bunnell, ... Bioorganic & medicinal chemistry letters 68, 128718, 2022 | 11 | 2022 |
| Benzopyrimidodiazepinone inhibitors of TNK2 BJ Groendyke, CE Powell, F Feru, TW Gero, Z Li, H Szabo, K Pang, ... Bioorganic & Medicinal Chemistry Letters 30 (4), 126948, 2020 | 8 | 2020 |
| Discovery of a series of benzopyrimidodiazepinone TNK2 inhibitors via scaffold morphing Z Li, CE Powell, BJ Groendyke, TW Gero, F Feru, J Feutrill, B Chen, B Li, ... Bioorganic & Medicinal Chemistry Letters 30 (19), 127456, 2020 | 4 | 2020 |
| Synthesis and Structure–Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold Z Li, R Ishida, Y Liu, J Wang, Y Li, Y Gao, J Jiang, J Che, JM Sheltzer, ... European journal of medicinal chemistry 238, 114433, 2022 | 3 | 2022 |
| ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases Z Li, W Lu, TS Beyett, SB Ficarro, J Jiang, J Tse, AYJ Kim, JA Marto, J Che, ... Journal of Medicinal Chemistry, 2024 | 1 | 2024 |
| Sulfonamide derivatives for protein degradation NS Gray, E Fischer, H Yoon, T Zhang, T Faust, K Donovan, CAI Quan, Z Li US Patent App. 18/375,003, 2024 | | 2024 |
| Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality Z Li, J Jiang, SB Ficarro, TS Beyett, C To, I Tavares, Y Zhu, J Li, MJ Eck, ... ACS Central Science, 2024 | | 2024 |
| Sulfonamide derivatives for protein degradation NS Gray, E Fischer, H Yoon, T Zhang, T Faust, K Donovan, CAI Quan, Z Li US Patent 11,807,606, 2023 | | 2023 |
| Covalent egfr inhibitors and methods of use thereof NS Gray, Z Li, J Che, T Zhang US Patent App. 18/191,589, 2023 | | 2023 |
| Modulation of Gene Expression Via Transcription Factor-Chemically Induced Proximity (TF-CIP) GR Crabtree, S Gourisankar, A Krokhotin, CY Chang, WC Wenderski, ... US Patent App. 18/143,492, 2023 | | 2023 |
| Covalent egfr inhibitors and methods of use thereof Z Li, J Che, T Zhang, NS Gray US Patent App. 18/191,574, 2023 | | 2023 |
| Small molecule covalent activators of ucp1 NS Gray, M Fan, M Ordonez, E Chouchani, T Zhang, Z Li, J Che US Patent App. 18/010,864, 2023 | | 2023 |
Eric S FischerProfessor of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolVerified email at crystal.harvard.edu
