Robert Prins
Robert Prins
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
L Dang, DW White, S Gross, BD Bennett, MA Bittinger, EM Driggers, ...
Nature 462 (7274), 739-744, 2009
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
TF Cloughesy, AY Mochizuki, JR Orpilla, W Hugo, AH Lee, TB Davidson, ...
Nature medicine 25 (3), 477-486, 2019
Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration
JS Yu, CJ Wheeler, PM Zeltzer, H Ying, DN Finger, PK Lee, WH Yong, ...
Cancer research 61 (3), 842-847, 2001
Immunotherapy response assessment in neuro-oncology: a report of the RANO working group
H Okada, M Weller, R Huang, G Finocchiaro, MR Gilbert, W Wick, ...
The Lancet Oncology 16 (15), e534-e542, 2015
Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment
LM Liau, RM Prins, SM Kiertscher, SK Odesa, TJ Kremen, AJ Giovannone, ...
Clinical Cancer Research 11 (15), 5515-5525, 2005
First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma
LM Liau, K Ashkan, DD Tran, JL Campian, JE Trusheim, CS Cobbs, ...
Journal of translational medicine 16, 1-9, 2018
Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy
RM Prins, H Soto, V Konkankit, SK Odesa, A Eskin, WH Yong, SF Nelson, ...
Clinical cancer research 17 (6), 1603-1615, 2011
An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR–dependent pathway
D Guo, F Reinitz, M Youssef, C Hong, D Nathanson, D Akhavan, D Kuga, ...
Cancer discovery 1 (5), 442-456, 2011
Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
WB Pope, RM Prins, M Albert Thomas, R Nagarajan, KE Yen, MA Bittinger, ...
Journal of neuro-oncology 107, 197-205, 2012
EGFR signaling through an Akt-SREBP-1–dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
D Guo, RM Prins, J Dang, D Kuga, A Iwanami, H Soto, KY Lin, TT Huang, ...
Science signaling 2 (101), ra82-ra82, 2009
Treatment of intracranial gliomas with bone marrow—derived dendritic cells pulsed with tumor antigens
LM Liau, KL Black, RM Prins, SN Sykes, PL DiPatre, TF Cloughesy, ...
Journal of neurosurgery 90 (6), 1115-1124, 1999
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
D Guo, IJ Hildebrandt, RM Prins, H Soto, MM Mazzotta, J Dang, J Czernin, ...
Proceedings of the National Academy of Sciences 106 (31), 12932-12937, 2009
2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling
X Fu, RM Chin, L Vergnes, H Hwang, G Deng, Y Xing, MY Pai, S Li, L Ta, ...
Cell metabolism 22 (3), 508-515, 2015
The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity
RM Prins, N Craft, KW Bruhn, H Khan-Farooqi, RC Koya, R Stripecke, ...
The Journal of Immunology 176 (1), 157-164, 2006
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity
KJ Williams, JP Argus, Y Zhu, MQ Wilks, BN Marbois, AG York, Y Kidani, ...
Cancer research 73 (9), 2850-2862, 2013
Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma
JP Antonios, H Soto, RG Everson, D Moughon, JR Orpilla, NP Shin, ...
Neuro-oncology 19 (6), 796-807, 2017
Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma: a phase 3 …
LM Liau, K Ashkan, S Brem, JL Campian, JE Trusheim, FM Iwamoto, ...
JAMA oncology 9 (1), 112-121, 2023
Cytomegalovirus immunity after vaccination with autologous glioblastoma lysate
RM Prins, TF Cloughesy, LM Liau
New England Journal of Medicine 359 (5), 539-541, 2008
Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients
RM Prins, X Wang, H Soto, E Young, DN Lisiero, B Fong, R Everson, ...
Journal of immunotherapy 36 (2), 152-157, 2013
Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824
DD Vo, RM Prins, JL Begley, TR Donahue, LF Morris, KW Bruhn, ...
Cancer research 69 (22), 8693-8699, 2009
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