Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis G Mallucci, A Dickinson, J Linehan, PC Klohn, S Brandner, J Collinge Science 302 (5646), 871-874, 2003 | 837 | 2003 |
Sustained translational repression by eIF2α-P mediates prion neurodegeneration JA Moreno, H Radford, D Peretti, JR Steinert, N Verity, MG Martin, ... Nature 485 (7399), 507-511, 2012 | 685 | 2012 |
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice JA Moreno, M Halliday, C Molloy, H Radford, N Verity, JM Axten, CA Ortori, ... Science translational medicine 5 (206), 206ra138-206ra138, 2013 | 633 | 2013 |
Post‐natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration GR Mallucci, S Ratte, EA Asante, J Linehan, I Gowland, JGR Jefferys, ... The EMBO journal, 2002 | 502 | 2002 |
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing B Boland, WH Yu, O Corti, B Mollereau, A Henriques, E Bezard, ... Nature reviews Drug discovery 17 (9), 660-688, 2018 | 438 | 2018 |
Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity M Halliday, H Radford, Y Sekine, J Moreno, N Verity, J Le Quesne, ... Cell death & disease 6 (3), e1672-e1672, 2015 | 337 | 2015 |
Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice GR Mallucci, MD White, M Farmer, A Dickinson, H Khatun, AD Powell, ... Neuron 53 (3), 325-335, 2007 | 318 | 2007 |
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice M Halliday, H Radford, KAM Zents, C Molloy, JA Moreno, NC Verity, ... Brain 140 (6), 1768-1783, 2017 | 284 | 2017 |
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia H Radford, JA Moreno, N Verity, M Halliday, GR Mallucci Acta neuropathologica 130, 633-642, 2015 | 271 | 2015 |
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration D Peretti, A Bastide, H Radford, N Verity, C Molloy, MG Martin, JA Moreno, ... Nature 518 (7538), 236-239, 2015 | 236 | 2015 |
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease MD White, M Farmer, I Mirabile, S Brandner, J Collinge, GR Mallucci Proceedings of the National Academy of Sciences 105 (29), 10238-10243, 2008 | 229 | 2008 |
Nerve Injury Induces Robust Allodynia and Ectopic Discharges in Nav1.3 Null Mutant Mice MA Nassar, MD Baker, A Levato, R Ingram, G Mallucci, SB McMahon, ... Molecular pain 2, 1744-8069-2-33, 2006 | 208 | 2006 |
Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease I Celardo, AC Costa, S Lehmann, C Jones, N Wood, NE Mencacci, ... Cell death & disease 7 (6), e2271-e2271, 2016 | 168 | 2016 |
Astrocyte unfolded protein response induces a specific reactivity state that causes non-cell-autonomous neuronal degeneration HL Smith, OJ Freeman, AJ Butcher, S Holmqvist, I Humoud, T Schätzl, ... Neuron 105 (5), 855-866. e5, 2020 | 166 | 2020 |
The unfolded protein response in neurodegenerative disorders–therapeutic modulation of the PERK pathway D Hughes, GR Mallucci The FEBS journal 286 (2), 342-355, 2019 | 166 | 2019 |
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease R Tufi, S Gandhi, IP De Castro, S Lehmann, PR Angelova, D Dinsdale, ... Nature cell biology 16 (2), 157-166, 2014 | 163 | 2014 |
The unfolded protein response: mechanisms and therapy of neurodegeneration HL Smith, GR Mallucci Brain 139 (8), 2113-2121, 2016 | 138 | 2016 |
Targeting the unfolded protein response in neurodegeneration: a new approach to therapy M Halliday, GR Mallucci Neuropharmacology 76, 169-174, 2014 | 127 | 2014 |
Rational targeting for prion therapeutics G Mallucci, J Collinge Nature Reviews Neuroscience 6 (1), 23-34, 2005 | 105 | 2005 |
Neuronal mitochondrial dysfunction activates the integrated stress response to induce fibroblast growth factor 21 LM Restelli, B Oettinghaus, M Halliday, C Agca, M Licci, L Sironi, ... Cell reports 24 (6), 1407-1414, 2018 | 89 | 2018 |