| An improved preparation of 3, 5-bis (trifluoromethyl) acetophenone and safety considerations in the preparation of 3, 5-bis (trifluoromethyl) phenyl Grignard reagent JL Leazer, R Cvetovich, FR Tsay, U Dolling, T Vickery, D Bachert The Journal of Organic Chemistry 68 (9), 3695-3698, 2003 | 95 | 2003 |
| A kinase-cGAS cascade to synthesize a therapeutic STING activator JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603 (7901), 439-444, 2022 | 60 | 2022 |
| Development of a new and practical route to chiral 3, 4-disubstituted cyclopentanones: Asymmetric alkylation and intramolecular cyclopropanation as key C− C bond-forming steps M Palucki, JM Um, N Yasuda, DA Conlon, FR Tsay, FW Hartner, Y Hsiao, ... The Journal of Organic Chemistry 67 (16), 5508-5516, 2002 | 49 | 2002 |
| Practical Synthesis of Anti-Methicillin-Resistant Staphylococcus Aureus (MRSA) Carbapenem L-742,728 N Yasuda, MA Huffman, GJ Ho, LC Xavier, C Yang, KM Emerson, ... The Journal of Organic Chemistry 63 (16), 5438-5446, 1998 | 42 | 1998 |
| Synthesis of a naphthyridone p38 MAP kinase inhibitor JYL Chung, RJ Cvetovich, M McLaughlin, J Amato, FR Tsay, M Jensen, ... The Journal of Organic Chemistry 71 (22), 8602-8609, 2006 | 36 | 2006 |
| Practical synthesis of the new carbapenem antibiotic ertapenem sodium JM Williams, KMJ Brands, RT Skerlj, RB Jobson, G Marchesini, ... The Journal of Organic Chemistry 70 (19), 7479-7487, 2005 | 33 | 2005 |
| Generic anion-exchange chromatography method for analytical and preparative separation of nucleotides in the development and manufacture of drug substances FR Tsay, IAH Ahmad, D Henderson, N Schiavone, Z Liu, AA Makarov, ... Journal of Chromatography A 1587, 129-135, 2019 | 29 | 2019 |
| Understanding the Origin of Unusual Stepwise Hydrogenation Kinetics in the Synthesis of the 3-(4-Fluorophenyl)morpholine Moiety of NK1 Receptor Antagonist … KMJ Brands, SW Krska, T Rosner, KM Conrad, EG Corley, M Kaba, ... Organic process research & development 10 (1), 109-117, 2006 | 28 | 2006 |
| An efficient synthesis of a dual PPAR α/γ agonist and the formation of a sterically congested α-aryloxyisobutyric acid via a Bargellini reaction RJ Cvetovich, JYL Chung, MH Kress, JS Amato, L Matty, MD Weingarten, ... The Journal of Organic Chemistry 70 (21), 8560-8563, 2005 | 28 | 2005 |
| Stereoselective syntheses of highly functionalized bicyclo [3.1. 0] hexanes: A general methodology for the synthesis of potent and selective mGluR2/3 agonists L Tan, N Yasuda, N Yoshikawa, FW Hartner, KK Eng, WR Leonard, ... The Journal of organic chemistry 70 (20), 8027-8034, 2005 | 24 | 2005 |
| A highly efficient synthesis of fibrinogen receptor antagonist L-734,217 via a novel chemoselective silyl-mediated conjugate addition of δ-lactams to 4-vinylpyridine JYL Chung, DL Hughes, D Zhao, Z Song, DJ Mathre, GJ Ho, ... The Journal of Organic Chemistry 61 (1), 215-222, 1996 | 22 | 1996 |
| Mapping the separation landscape of pharmaceuticals: rapid and efficient scale-up of preparative purifications enabled by computer-assisted chromatographic method development R Bennett, IA Haidar Ahmad, J DaSilva, M Figus, K Hullen, FR Tsay, ... Organic Process Research & Development 23 (12), 2678-2684, 2019 | 19 | 2019 |
| Stereoselective synthesis of an anti‐HIV drug candidate DA Conlon, MS Jensen, M Palucki, N Yasuda, JM Um, C Yang, ... Chirality 17 (S1), S149-S158, 2005 | 19 | 2005 |
| Highly Chemoselective Trichloroacetimidate-Mediated Alkylation of Ascomycin: A Convergent, Practical Synthesis of the Immunosuppressant L-733,725 Z Song, A DeMarco, M Zhao, EG Corley, AS Thompson, J McNamara, Y Li, ... The Journal of Organic Chemistry 64 (6), 1859-1867, 1999 | 18 | 1999 |
| Synthesis of 3-Aminopyrazinone Mediated by 2-Pyridylthioimidate−ZnCl2 Complexes. Development of an Efficient Route to a Thrombin Inhibitor JYL Chung, RJ Cvetovich, FR Tsay, PG Dormer, L DiMichele, DJ Mathre, ... The Journal of Organic Chemistry 68 (23), 8838-8846, 2003 | 16 | 2003 |
| Canada, KA; Bulger, PG; Sherry, BD; Truppo, M. D.; Ruck, RT; Campeau, L.-C.; Bennett, DJ; Humphrey, GR; Campos, KR; Maddess, ML A Kinase-cGAS Cascade to Synthesize a … JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603 (7901), 439-444, 2022 | 15 | 2022 |
| Structures of three substituted pentacyclo[5.4.0.02, 6.03, 10.05, 9]undecanes and a computational analysis of bond lengths WH Watson, RP Kashyap, M Krawiec, AP Marchand, FR Tsay Structural Chemistry 5, 21-35, 1994 | 14 | 1994 |
| Automated ion exchange chromatography screening combined with in silico multifactorial simulation for efficient method development and purification of biopharmaceutical targets GL Losacco, MB Hicks, JO DaSilva, H Wang, M Potapenko, FR Tsay, ... Analytical and Bioanalytical Chemistry 414 (12), 3581-3591, 2022 | 10 | 2022 |
| KA Canada, PG Bulger, BD Sherry, MD Truppo, RT Ruck, L.-C. Campeau, DJ Bennett, GR Humphrey, KR Campos and ML Maddess, A Kinase-cGAS Cascade to Synthesize a Therapeutic STING … JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603, 439-444, 2022 | 9 | 2022 |
| A highly convergent synthesis of a fibrinogen receptor antagonist FW Hartner, RJ Cvetovich, FR Tsay, JS Amato, B Pipik, EJJ Grabowski, ... The Journal of Organic Chemistry 64 (21), 7751-7755, 1999 | 9 | 1999 |
