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Nikhil Wagle
Nikhil Wagle
Dana-Farber Cancer Institute, Harvard Medical School / Broad Institute of MIT and Harvard
Verified email at dfci.harvard.edu - Homepage
Title
Cited by
Cited by
Year
A landscape of driver mutations in melanoma
E Hodis, IR Watson, GV Kryukov, ST Arold, M Imielinski, JP Theurillat, ...
Cell 150 (2), 251-263, 2012
29022012
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
N Wagle, C Emery, MF Berger, MJ Davis, A Sawyer, P Pochanard, ...
Journal of clinical oncology 29 (22), 3085, 2011
11882011
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma
EM Van Allen, N Wagle, A Sucker, DJ Treacy, CM Johannessen, ...
Cancer discovery 4 (1), 94-109, 2014
9502014
Melanoma genome sequencing reveals frequent PREX2 mutations
MF Berger, E Hodis, TP Heffernan, YL Deribe, MS Lawrence, ...
Nature 485 (7399), 502-506, 2012
8732012
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group
F Mosele, J Remon, J Mateo, CB Westphalen, F Barlesi, MP Lolkema, ...
Annals of Oncology 31 (11), 1491-1505, 2020
8432020
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
VA Adalsteinsson, G Ha, SS Freeman, AD Choudhury, DG Stover, ...
Nature communications 8 (1), 1324, 2017
7292017
High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
N Wagle, MF Berger, MJ Davis, B Blumenstiel, M DeFelice, P Pochanard, ...
Cancer discovery 2 (1), 82-93, 2012
6172012
Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma
EM Van Allen, KW Mouw, P Kim, G Iyer, N Wagle, H Al-Ahmadie, C Zhu, ...
Cancer discovery 4 (10), 1140-1153, 2014
5742014
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine
EM Van Allen, N Wagle, P Stojanov, DL Perrin, K Cibulskis, S Marlow, ...
Nature medicine 20 (6), 682-688, 2014
5622014
MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition
N Wagle, EM Van Allen, DJ Treacy, DT Frederick, ZA Cooper, ...
Cancer discovery 4 (1), 61-68, 2014
5242014
A p53-dependent checkpoint pathway prevents rereplication
C Vaziri, S Saxena, Y Jeon, C Lee, K Murata, Y Machida, N Wagle, ...
Molecular cell 11 (4), 997-1008, 2003
4722003
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
JA Perry, A Kiezun, P Tonzi, EM Van Allen, SL Carter, SC Baca, ...
Proceedings of the National Academy of Sciences 111 (51), E5564-E5573, 2014
4272014
A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
M Slyper, CBM Porter, O Ashenberg, J Waldman, E Drokhlyansky, ...
Nature medicine 26 (5), 792-802, 2020
4232020
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition
SR Whittaker, JP Theurillat, E Van Allen, N Wagle, J Hsiao, GS Cowley, ...
Cancer discovery 3 (3), 350-362, 2013
4232013
A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma
JE Rosenberg, RM Bambury, EM Van Allen, HA Drabkin, PN Lara, ...
Investigational new drugs 32, 178-187, 2014
3722014
The human tumor atlas network: charting tumor transitions across space and time at single-cell resolution
O Rozenblatt-Rosen, A Regev, P Oberdoerffer, T Nawy, A Hupalowska, ...
Cell 181 (2), 236-249, 2020
3702020
Response and acquired resistance to everolimus in anaplastic thyroid cancer
N Wagle, BC Grabiner, EM Van Allen, A Amin-Mansour, A Taylor-Weiner, ...
New England Journal of Medicine 371 (15), 1426-1433, 2014
3542014
Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations
LG Ahronian, EM Sennott, EM Van Allen, N Wagle, EL Kwak, JE Faris, ...
Cancer discovery 5 (4), 358-367, 2015
3122015
Assessing the clinical utility of cancer genomic and proteomic data across tumor types
Y Yuan, EM Van Allen, L Omberg, N Wagle, A Amin-Mansour, A Sokolov, ...
Nature biotechnology 32 (7), 644-652, 2014
3102014
Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine
AJ Aguirre, JA Nowak, ND Camarda, RA Moffitt, AA Ghazani, ...
Cancer discovery 8 (9), 1096-1111, 2018
3032018
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