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Dominic G Whittaker
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Calibration of ionic and cellular cardiac electrophysiology models
DG Whittaker, M Clerx, CL Lei, DJ Christini, GR Mirams
Wiley Interdisciplinary Reviews: Systems Biology and Medicine 12 (4), e1482, 2020
932020
Emerging therapeutic targets in the short QT syndrome
JC Hancox, DG Whittaker, C Du, AG Stuart, H Zhang
Expert opinion on therapeutic targets 22 (5), 439-451, 2018
542018
Considering discrepancy when calibrating a mechanistic electrophysiology model
CL Lei, S Ghosh, DG Whittaker, Y Aboelkassem, KA Beattie, CD Cantwell, ...
Philosophical Transactions of the Royal Society A 378 (2173), 20190349, 2020
512020
Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments
CL Lei, M Clerx, DG Whittaker, DJ Gavaghan, TP de Boer, GR Mirams
Philosophical Transactions of the Royal Society A 378 (2173), 20190348, 2020
512020
Synergistic anti-arrhythmic effects in human atria with combined use of sodium blockers and acacetin
H Ni, DG Whittaker, W Wang, WR Giles, SM Narayan, H Zhang
Frontiers in Physiology 8, 946, 2017
402017
Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles
DG Whittaker, H Ni, AP Benson, JC Hancox, H Zhang
Frontiers in physiology 8, 297002, 2017
372017
Human atrial arrhythmogenesis and sinus bradycardia in KCNQ1-linked short QT syndrome: insights from computational modelling
DG Whittaker, MA Colman, H Ni, JC Hancox, H Zhang
Frontiers in physiology 9, 410479, 2018
322018
Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria
DG Whittaker, H Ni, A El Harchi, JC Hancox, H Zhang
PLoS Computational Biology 13 (6), e1005593, 2017
312017
In silico investigation of a KCNQ1 mutation associated with short QT syndrome
I Adeniran, DG Whittaker, A El Harchi, JC Hancox, H Zhang
Scientific reports 7 (1), 8469, 2017
262017
Multi-scale approaches for the simulation of cardiac electrophysiology: II–Tissue-level structure and function
AP Benson, HJ Stevenson-Cocks, DG Whittaker, E White, MA Colman
Methods 185, 60-81, 2021
172021
In silico assessment of pharmacotherapy for human atrial patho-electrophysiology associated with hERG-linked short QT syndrome
DG Whittaker, JC Hancox, H Zhang
Frontiers in physiology 9, 417422, 2019
152019
Multi-scale approaches for the simulation of cardiac electrophysiology: I–Sub-cellular and stochastic calcium dynamics from cell to organ
MA Colman, M Holmes, DG Whittaker, I Jayasinghe, AP Benson
Methods 185, 49-59, 2021
132021
Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243
JM Kemp, DG Whittaker, R Venkateshappa, ZK Pang, R Johal, V Sergeev, ...
Journal of General Physiology 153 (10), e202112923, 2021
122021
Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine
DG Whittaker, RA Capel, M Hendrix, XHS Chan, N Herring, NJ White, ...
Royal Society Open Science 8 (4), 210235, 2021
102021
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer
CL Lei, A Fabbri, DG Whittaker, M Clerx, MJ Windley, AP Hill, GR Mirams, ...
Wellcome Open Research 5, 2020
102020
Effects of heart rate and ventricular wall thickness on non-invasive mapping: an in silico study
EA Perez Alday, DG Whittaker, AP Benson, MA Colman
Frontiers in physiology 10, 424824, 2019
102019
Investigation of the role of myocyte orientations in cardiac arrhythmia using image-based models
DG Whittaker, AP Benson, I Teh, JE Schneider, MA Colman
Biophysical Journal 117 (12), 2396-2408, 2019
92019
The short QT syndrome
JC Hancox, MJ McPate, A El Harchi, AS Butler, Y Zhang, DG Whittaker, ...
Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation and …, 2023
82023
Learning from studying very rare cardiac conditions: the example of short QT syndrome
JC Hancox, DG Whittaker, H Zhang, AG Stuart
Journal of Congenital Cardiology 3, 1-15, 2019
82019
Calibration of ionic and cellular cardiac electrophysiology models. Wires Syst Biol Med 12 (4): e1482
DG Whittaker, M Clerx, CL Lei, DJ Christini, GR Mirams
52020
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