Andrew Chan
Andrew Chan
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5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical Science 4 (8), 3110-3117, 2013
Selective small molecule probes for the Hypoxia Inducible Factor (HIF) prolyl hydroxylases
R Chowdhury, JI Candela-Lena, MC Chan, DJ Greenald, KK Yeoh, ...
ACS chemical biology 8 (7), 1488-1496, 2013
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of Medicinal Chemistry 55 (14), 6639-6643, 2012
Pharmacological targeting of the HIF hydroxylases–A new field in medicine development
MC Chan, JP Holt-Martyn, CJ Schofield, PJ Ratcliffe
Molecular aspects of medicine 47, 54-75, 2016
Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors
M Demetriades, IKH Leung, R Chowdhury, MC Chan, MA McDonough, ...
Angewandte Chemie 124 (27), 6776-6779, 2012
Linking of 2‐oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases
ECY Woon, A Tumber, A Kawamura, L Hillringhaus, W Ge, NR Rose, ...
Angewandte Chemie 124 (7), 1663-1666, 2012
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
H Tarhonskaya, AM Rydzik, IKH Leung, ND Loik, MC Chan, A Kawamura, ...
Nature communications 5 (1), 1-10, 2014
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
MC Chan, NE Ilott, J Schödel, D Sims, A Tumber, K Lippl, DR Mole, ...
Journal of Biological Chemistry 291 (39), 20661-20673, 2016
A Cell‐Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1
R Schiller, G Scozzafava, A Tumber, JR Wickens, JT Bush, G Rai, ...
ChemMedChem 9 (3), 566-571, 2014
An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability
J Schütte, H Wang, S Antoniou, A Jarratt, NK Wilson, J Riepsaame, ...
Elife 5, e11469, 2016
Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
ECY Woon, M Demetriades, EAL Bagg, WS Aik, SM Krylova, JHY Ma, ...
Journal of Medicinal Chemistry 55 (5), 2173-2184, 2012
Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain
MC Chan, O Atasoylu, E Hodson, A Tumber, IKH Leung, R Chowdhury, ...
PLoS One 10 (7), e0132004, 2015
Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases
CC Thinnes, A Tumber, C Yapp, G Scozzafava, T Yeh, MC Chan, TA Tran, ...
Chemical Communications 51 (84), 15458-15461, 2015
Inhibition of the HIF1α-p300 interaction by quinone-and indandione-mediated ejection of structural Zn (II)
MKP Jayatunga, S Thompson, TC McKee, MC Chan, KM Reece, ...
European Journal of Medicinal Chemistry, 2014
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
KK Yeoh, MC Chan, A Thalhammer, M Demetriades, R Chowdhury, ...
Organic & biomolecular chemistry 11 (5), 732-745, 2013
Quantitative MS‐Based Proteomics: Comparing the MCF‐7 Cellular Response to Hypoxia and a 2‐Oxoglutarate Analogue
JT Bush, MC Chan, S Mohammed, CJ Schofield
ChemBioChem 21 (11), 1647, 2020
Evaluation of 3-carbamoylpropanoic acid analogs as inhibitors of human hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes
MP Chong, LR Toh, A Tumber, YY Chan, MC Chan, MI Abboud, ...
Medicinal Chemistry Research 30 (4), 977-986, 2021
Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases
MC Chan
University of Oxford, 2014
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