|5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation|
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical Science 4 (8), 3110-3117, 2013
|Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases|
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of Medicinal Chemistry 55 (14), 6639-6643, 2012
|Selective small molecule probes for the Hypoxia Inducible Factor (HIF) prolyl hydroxylases|
R Chowdhury, JI Candela-Lena, MC Chan, DJ Greenald, KK Yeoh, ...
ACS chemical biology 8 (7), 1488-1496, 2013
|Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors|
M Demetriades, IKH Leung, R Chowdhury, MC Chan, MA McDonough, ...
Angewandte Chemie International Edition 51 (27), 6672-6675, 2012
|Pharmacological targeting of the HIF hydroxylases–A new field in medicine development|
MC Chan, JP Holt-Martyn, CJ Schofield, PJ Ratcliffe
Molecular aspects of medicine 47, 54-75, 2016
|Linking of 2‐Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases|
ECY Woon, A Tumber, A Kawamura, L Hillringhaus, W Ge, NR Rose, ...
Angewandte Chemie International Edition 51 (7), 1631-1634, 2012
|Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases|
H Tarhonskaya, AM Rydzik, IKH Leung, ND Loik, MC Chan, A Kawamura, ...
Nature communications 5 (1), 1-10, 2014
|Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase|
ECY Woon, M Demetriades, EAL Bagg, WS Aik, SM Krylova, JHY Ma, ...
Journal of Medicinal Chemistry 55 (5), 2173-2184, 2012
|A Cell‐Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1|
R Schiller, G Scozzafava, A Tumber, JR Wickens, JT Bush, G Rai, ...
ChemMedChem 9 (3), 566-571, 2014
|Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases|
MC Chan, NE Ilott, J Schödel, D Sims, A Tumber, K Lippl, DR Mole, ...
Journal of Biological Chemistry 291 (39), 20661-20673, 2016
|An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability|
J Schütte, H Wang, S Antoniou, A Jarratt, NK Wilson, J Riepsaame, ...
Elife 5, e11469, 2016
|Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain|
MC Chan, O Atasoylu, E Hodson, A Tumber, IKH Leung, R Chowdhury, ...
PLoS One 10 (7), 2015
|Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases|
CC Thinnes, A Tumber, C Yapp, G Scozzafava, T Yeh, MC Chan, TA Tran, ...
Chemical Communications 51 (84), 15458-15461, 2015
|Inhibition of the HIF1α-p300 interaction by quinone-and indandione-mediated ejection of structural Zn (II)|
MKP Jayatunga, S Thompson, TC McKee, MC Chan, KM Reece, ...
European Journal of Medicinal Chemistry, 2014
|Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion|
KK Yeoh, MC Chan, A Thalhammer, M Demetriades, R Chowdhury, ...
Organic & biomolecular chemistry 11 (5), 732-745, 2013
|Quantitative MS‐based proteomics comparing the MCF‐7 cellular response to hypoxia and a 2‐oxoglutarate analogue|
JT Bush, MC Chan, S Mohammed, C Schofield
|Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases|
University of Oxford, 2014