| 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ... Chemical Science 4 (8), 3110-3117, 2013 | 124 | 2013 |
| Selective small molecule probes for the Hypoxia Inducible Factor (HIF) prolyl hydroxylases R Chowdhury, JI Candela-Lena, MC Chan, DJ Greenald, KK Yeoh, ... ACS chemical biology 8 (7), 1488-1496, 2013 | 107 | 2013 |
| Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ... Journal of Medicinal Chemistry 55 (14), 6639-6643, 2012 | 105 | 2012 |
| Pharmacological targeting of the HIF hydroxylases–A new field in medicine development MC Chan, JP Holt-Martyn, CJ Schofield, PJ Ratcliffe Molecular aspects of medicine 47, 54-75, 2016 | 98 | 2016 |
| Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors M Demetriades, IKH Leung, R Chowdhury, MC Chan, MA McDonough, ... Angewandte Chemie 124 (27), 6776-6779, 2012 | 80 | 2012 |
| Linking of 2‐oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases ECY Woon, A Tumber, A Kawamura, L Hillringhaus, W Ge, NR Rose, ... Angewandte Chemie 124 (7), 1663-1666, 2012 | 65 | 2012 |
| Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases H Tarhonskaya, AM Rydzik, IKH Leung, ND Loik, MC Chan, A Kawamura, ... Nature communications 5 (1), 1-10, 2014 | 61 | 2014 |
| Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases MC Chan, NE Ilott, J Schödel, D Sims, A Tumber, K Lippl, DR Mole, ... Journal of Biological Chemistry 291 (39), 20661-20673, 2016 | 52 | 2016 |
| A Cell‐Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1 R Schiller, G Scozzafava, A Tumber, JR Wickens, JT Bush, G Rai, ... ChemMedChem 9 (3), 566-571, 2014 | 52 | 2014 |
| An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability J Schütte, H Wang, S Antoniou, A Jarratt, NK Wilson, J Riepsaame, ... Elife 5, e11469, 2016 | 50 | 2016 |
| Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase ECY Woon, M Demetriades, EAL Bagg, WS Aik, SM Krylova, JHY Ma, ... Journal of Medicinal Chemistry 55 (5), 2173-2184, 2012 | 49 | 2012 |
| Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain MC Chan, O Atasoylu, E Hodson, A Tumber, IKH Leung, R Chowdhury, ... PLoS One 10 (7), e0132004, 2015 | 41 | 2015 |
| Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases CC Thinnes, A Tumber, C Yapp, G Scozzafava, T Yeh, MC Chan, TA Tran, ... Chemical Communications 51 (84), 15458-15461, 2015 | 31 | 2015 |
| Inhibition of the HIF1α-p300 interaction by quinone-and indandione-mediated ejection of structural Zn (II) MKP Jayatunga, S Thompson, TC McKee, MC Chan, KM Reece, ... European Journal of Medicinal Chemistry, 2014 | 29 | 2014 |
| Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion KK Yeoh, MC Chan, A Thalhammer, M Demetriades, R Chowdhury, ... Organic & biomolecular chemistry 11 (5), 732-745, 2013 | 23 | 2013 |
| Quantitative MS‐Based Proteomics: Comparing the MCF‐7 Cellular Response to Hypoxia and a 2‐Oxoglutarate Analogue JT Bush, MC Chan, S Mohammed, CJ Schofield ChemBioChem 21 (11), 1647, 2020 | 5 | 2020 |
| Evaluation of 3-carbamoylpropanoic acid analogs as inhibitors of human hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes MP Chong, LR Toh, A Tumber, YY Chan, MC Chan, MI Abboud, ... Medicinal Chemistry Research 30 (4), 977-986, 2021 | | 2021 |
| Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases MC Chan University of Oxford, 2014 | | 2014 |
