Miranda Orr
Miranda Orr
Wake Forest University School of Medicine
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Cited by
Cited by
Tau protein aggregation is associated with cellular senescence in the brain
N Musi, JM Valentine, KR Sickora, E Baeuerle, CS Thompson, Q Shen, ...
Aging cell 17 (6), e12840, 2018
A brief overview of tauopathy: causes, consequences, and therapeutic strategies
ME Orr, AC Sullivan, B Frost
Trends in pharmacological sciences 38 (7), 637-648, 2017
Autophagic/lysosomal dysfunction in Alzheimer’s disease
ME Orr, S Oddo
Alzheimer's research & therapy 5, 1-9, 2013
Biological aging processes underlying cognitive decline and neurodegenerative disease
MM Gonzales, VR Garbarino, E Pollet, JP Palavicini, DL Kellogg, E Kraig, ...
The Journal of clinical investigation 132 (10), 2022
Mechanisms of oxidative stress resistance in the brain: lessons learned from hypoxia tolerant extremophilic vertebrates
VR Garbarino, ME Orr, KA Rodriguez, R Buffenstein
Archives of biochemistry and biophysics 576, 8-16, 2015
Senolytic therapy to modulate the progression of Alzheimer’s disease (SToMP-AD): a pilot clinical trial
MM Gonzales, VR Garbarino, EM Zilli, RC Petersen, JL Kirkland, ...
The journal of prevention of Alzheimer's disease, 1-8, 2022
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology
ME Orr, A Salinas, R Buffenstein, S Oddo
Neurobiology of aging 35 (6), 1233-1242, 2014
Age-related changes in the proteostasis network in the brain of the naked mole-rat: implications promoting healthy longevity
JC Triplett, A Tramutola, A Swomley, J Kirk, K Grimes, K Lewis, M Orr, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852 (10 …, 2015
Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons
L George, M Chaverra, L Wolfe, J Thorne, M Close-Davis, A Eibs, ...
Proceedings of the National Academy of Sciences 110 (46), 18698-18703, 2013
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology
SK Dehkordi, J Walker, E Sah, E Bennett, F Atrian, B Frost, B Woost, ...
Nature Aging 1 (12), 1107-1116, 2021
The role of FLO11 in Saccharomyces cerevisiae biofilm development in a laboratory based flow-cell system
B Purevdorj-Gage, ME Orr, P Stoodley, KB Sheehan, LE Hyman
FEMS yeast research 7 (3), 372-379, 2007
Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice
DX Medina, ME Orr, S Oddo
Neurobiology of aging 35 (1), 79-87, 2014
Extended postnatal brain development in the longest-lived rodent: prolonged maintenance of neotenous traits in the naked mole-rat brain
ME Orr, VR Garbarino, A Salinas, R Buffenstein
Frontiers in neuroscience 10, 213874, 2016
The landscape of human tissue and cell type specific expression and co-regulation of senescence genes
P Xu, M Wang, W Song, Q Wang, GC Yuan, PH Sudmant, H Zare, Z Tu, ...
Molecular Neurodegeneration 17, 1-20, 2022
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application
M Wang, W Song, C Ming, Q Wang, X Zhou, P Xu, A Krek, Y Yoon, L Ho, ...
Molecular neurodegeneration 17 (1), 17, 2022
Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system
P Ramirez, G Zuniga, W Sun, A Beckmann, E Ochoa, SL DeVos, B Hyman, ...
Progress in neurobiology 208, 102181, 2022
The cellular senescence stress response in post-mitotic brain cells: Cell survival at the expense of tissue degeneration
E Sah, S Krishnamurthy, MY Ahmidouch, GJ Gillispie, C Milligan, ME Orr
Life 11 (3), 229, 2021
Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
MM Gonzales, VR Garbarino, TF Kautz, JP Palavicini, M Lopez-Cruzan, ...
Nature medicine 29 (10), 2481-2488, 2023
Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent
ME Orr, VR Garbarino, A Salinas, R Buffenstein
Neurobiology of aging 36 (3), 1496-1504, 2015
Can oral health and oral‐derived biospecimens predict progression of dementia?
ME Orr, KR Reveles, CK Yeh, EH Young, X Han
Oral diseases 26 (2), 249-258, 2020
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