The spliceosome is a therapeutic vulnerability in MYC-driven cancer TYT Hsu, LM Simon, NJ Neill, R Marcotte, A Sayad, CS Bland, ... Nature 525 (7569), 384-388, 2015 | 456 | 2015 |
Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance R Marcotte, A Sayad, KR Brown, F Sanchez-Garcia, J Reimand, M Haider, ... Cell 164 (1), 293-309, 2016 | 452 | 2016 |
Essential gene profiles in breast, pancreatic, and ovarian cancer cells R Marcotte, KR Brown, F Suarez, A Sayad, K Karamboulas, ... Cancer discovery 2 (2), 172-189, 2012 | 375 | 2012 |
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression RL Dillon, R Marcotte, BT Hennessy, JR Woodgett, GB Mills, WJ Muller Cancer research 69 (12), 5057-5064, 2009 | 207 | 2009 |
Senescent fibroblasts resist apoptosis by downregulating caspase-3 R Marcotte, C Lacelle, E Wang Mechanisms of ageing and development 125 (10-11), 777-783, 2004 | 179 | 2004 |
Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis LB Ruest, R Marcotte, E Wang Journal of Biological Chemistry 277 (7), 5418-5425, 2002 | 164 | 2002 |
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia RS Banh, C Iorio, R Marcotte, Y Xu, D Cojocari, AA Rahman, J Pawling, ... Nature cell biology 18 (7), 803-813, 2016 | 114 | 2016 |
Replicative senescence revisited R Marcotte, E Wang The Journals of Gerontology Series A: Biological Sciences and Medical …, 2002 | 108 | 2002 |
The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1 J Cullis, D Meiri, MJ Sandi, N Radulovich, OA Kent, M Medrano, ... Cancer cell 25 (2), 181-195, 2014 | 95 | 2014 |
Signaling pathway for apoptosis: a racetrack for life or death E Wang, R Marcotte, E Petroulakis Journal of Cellular Biochemistry 75 (S32), 95-102, 1999 | 77 | 1999 |
c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential R Marcotte, L Zhou, H Kim, CD Roskelly, WJ Muller Molecular and cellular biology 29 (21), 5858-5871, 2009 | 70 | 2009 |
Essential gene profiles in breast, pancreatic, and ovarian cancer cells. Cancer Discov. 2012; 2: 172–189. doi: 10.1158/2159-8290 R Marcotte, KR Brown, F Suarez, A Sayad, K Karamboulas, ... CD-11-0224.[Europe PMC free article][Abstract][CrossRef][Google Scholar], 2012 | 64 | 2012 |
Alterations in TNF‐and IL‐related gene expression in space‐flown WI38 human fibroblasts A Semov, N Semova, C Lacelle, R Marcotte, E Petroulakis, G Proestou, ... The FASEB Journal 16 (8), 899-901, 2002 | 63 | 2002 |
Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis R Marcotte, HW Smith, V Sanguin-Gendreau, RV McDonough, WJ Muller Proceedings of the National Academy of Sciences 109 (8), 2808-2813, 2012 | 57 | 2012 |
Signal transduction in transgenic mouse models of human breast cancer—implications for human breast cancer R Marcotte, WJ Muller Journal of mammary gland biology and neoplasia 13, 323-335, 2008 | 57 | 2008 |
CUX2 protein functions as an accessory factor in the repair of oxidative DNA damage R Pal, ZM Ramdzan, S Kaur, PM Duquette, R Marcotte, L Leduy, ... Journal of Biological Chemistry 290 (37), 22520-22531, 2015 | 51 | 2015 |
Microarray analysis of E-box binding-related gene expression in young and replicatively senescent human fibroblasts A Semov, R Marcotte, N Semova, X Ye, E Wang Analytical biochemistry 302 (1), 38-51, 2002 | 46 | 2002 |
Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival NU Nair, A Das, VM Rogkoti, M Fokkelman, R Marcotte, CG de Jong, ... Scientific reports 9 (1), 10989, 2019 | 34 | 2019 |
Germline variants associated with leukocyte genes predict tumor recurrence in breast cancer patients JS Milanese, C Tibiche, J Zou, Z Meng, A Nantel, S Drouin, R Marcotte, ... NPJ precision oncology 3 (1), 28, 2019 | 21 | 2019 |
hMad4, c‐Myc endogenous inhibitor, induces a replicative senescence‐like state when overexpressed in human fibroblasts R Marcotte, JF Qian, J Chen, E Wang Journal of cellular biochemistry 89 (3), 576-588, 2003 | 15 | 2003 |