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| Target validation using chemical probes ME Bunnage, ELP Chekler, LH Jones Nature chemical biology 9 (4), 195-199, 2013 | 452 | 2013 |
| Getting pharmaceutical R&D back on target ME Bunnage Nature chemical biology 7 (6), 335-339, 2011 | 371 | 2011 |
| Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ... Journal of the American Chemical Society 136 (26), 9308-9319, 2014 | 321 | 2014 |
| PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains S Picaud, D Da Costa, A Thanasopoulou, P Filippakopoulos, PV Fish, ... Cancer research 73 (11), 3336-3346, 2013 | 288 | 2013 |
| Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit PV Fish, P Filippakopoulos, G Bish, PE Brennan, ME Bunnage, AS Cook, ... Journal of medicinal chemistry 55 (22), 9831-9837, 2012 | 251 | 2012 |
| Applications of chemogenomic library screening in drug discovery LH Jones, ME Bunnage Nature reviews Drug discovery 16 (4), 285-296, 2017 | 183 | 2017 |
| (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells D Barsyte-Lovejoy, F Li, MJ Oudhoff, JH Tatlock, A Dong, H Zeng, H Wu, ... Proceedings of the National Academy of Sciences 111 (35), 12853-12858, 2014 | 182 | 2014 |
| Total synthesis of balanol KC Nicolaou, ME Bunnage, K Koide Journal of the American Chemical Society 116 (18), 8402-8403, 1994 | 150 | 1994 |
| Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance O Fedorov, J Castex, C Tallant, DR Owen, S Martin, M Aldeghi, ... Science advances 1 (10), e1500723, 2015 | 142 | 2015 |
| Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase N Narayana, TC Diller, K Koide, ME Bunnage, KC Nicolaou, LL Brunton, ... Biochemistry 38 (8), 2367-2376, 1999 | 134 | 1999 |
| Fluorine in drug design: a case study with fluoroanisoles L Xing, DC Blakemore, A Narayanan, R Unwalla, F Lovering, RA Denny, ... ChemMedChem 10 (4), 715-726, 2015 | 131 | 2015 |
| Total synthesis of brevetoxin A: Part 1: First generation strategy and construction of BCD ring system KC Nicolaou, ME Bunnage, DG McGarry, S Shi, PK Somers, PA Wallace, ... Chemistry–A European Journal 5 (2), 599-617, 1999 | 125 | 1999 |
| Know your target, know your molecule ME Bunnage, AM Gilbert, LH Jones, EC Hett Nature chemical biology 11 (6), 368-372, 2015 | 114 | 2015 |
| Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3′, 5′-monophosphate phosphodiesterase (cGMP-PDE5) for the treatment of sexual dysfunction ME Bunnage, JP Mathias, SDA Street, A Wood US Patent 6,916,927, 2005 | 111 | 2005 |
| Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease DS Millan, ME Bunnage, JL Burrows, KJ Butcher, PG Dodd, TJ Evans, ... Journal of medicinal chemistry 54 (22), 7797-7814, 2011 | 110 | 2011 |
| Total synthesis of brevetoxin A: Part 2: Second generation strategy and construction of EFGH model system KC Nicolaou, PA Wallace, S Shi, MA Ouellette, ME Bunnage, JL Gunzner, ... Chemistry–A European Journal 5 (2), 618-627, 1999 | 98 | 1999 |
| Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit BS Gerstenberger, JD Trzupek, C Tallant, O Fedorov, P Filippakopoulos, ... Journal of medicinal chemistry 59 (10), 4800-4811, 2016 | 97 | 2016 |
| An expeditious asymmetric synthesis of allophenylnorstatine ME Bunnage, SG Davies, CJ Goodwin, O Ichihara Tetrahedron 50 (13), 3975-3986, 1994 | 97* | 1994 |
| Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol K Koide, ME Bunnage, LG Paloma, JR Kanter, SS Taylor, LL Brunton, ... Chemistry & biology 2 (9), 601-608, 1995 | 94 | 1995 |
