Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson’s disease S Kim, SH Kwon, TI Kam, N Panicker, SS Karuppagounder, S Lee, JH Lee, ... Neuron 103 (4), 627-641. e7, 2019 | 1046 | 2019 |
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease SP Yun, TI Kam, N Panicker, SM Kim, Y Oh, JS Park, SH Kwon, YJ Park, ... Nature medicine 24 (7), 931-938, 2018 | 858 | 2018 |
Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease D Kim, JM Yoo, H Hwang, J Lee, SH Lee, SP Yun, MJ Park, MJ Lee, ... Nature nanotechnology 13 (9), 812-818, 2018 | 370 | 2018 |
GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers S Kim, SP Yun, S Lee, GE Umanah, VVR Bandaru, X Yin, P Rhee, ... Proceedings of the National Academy of Sciences 115 (4), 798-803, 2018 | 178 | 2018 |
α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism SP Yun, D Kim, S Kim, SM Kim, SS Karuppagounder, SH Kwon, S Lee, ... Molecular neurodegeneration 13, 1-19, 2018 | 84 | 2018 |
Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy SH Kuo, I Tasset, MM Cheng, A Diaz, MK Pan, OJ Lieberman, SJ Hutten, ... Science Advances 8 (6), eabm6393, 2022 | 78 | 2022 |
The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson’s disease mouse model S Lee, S Kim, YJ Park, SP Yun, SH Kwon, D Kim, DY Kim, JS Shin, ... Human molecular genetics 27 (13), 2344-2356, 2018 | 63 | 2018 |
Macro histone H2A1. 2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase W Kim, G Chakraborty, S Kim, J Shin, CH Park, MW Jeong, N Bharatham, ... Journal of Biological Chemistry 287 (8), 5278-5289, 2012 | 50 | 2012 |
Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson’s disease S Brahmachari, S Lee, S Kim, C Yuan, SS Karuppagounder, P Ge, R Shi, ... Brain 142 (8), 2380-2401, 2019 | 49 | 2019 |
Therapeutic approaches for inhibition of protein aggregation in Huntington's disease S Kim, KT Kim Experimental neurobiology 23 (1), 36, 2014 | 43 | 2014 |
Vaccinia-related kinase 2 controls the stability of the eukaryotic chaperonin TRiC/CCT by inhibiting the deubiquitinating enzyme USP25 S Kim, D Lee, J Lee, H Song, HJ Kim, KT Kim Molecular and Cellular Biology 35 (10), 1754-1762, 2015 | 31 | 2015 |
Complement and coagulation cascades are potentially involved in dopaminergic neurodegeneration in α-synuclein-based mouse models of Parkinson’s disease SX Ma, BA Seo, D Kim, Y Xiong, SH Kwon, S Brahmachari, S Kim, TI Kam, ... Journal of proteome research 20 (7), 3428-3443, 2021 | 30 | 2021 |
Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC S Kim, DY Park, D Lee, W Kim, YH Jeong, J Lee, SK Chung, H Ha, ... Molecular and cellular biology 34 (4), 643-652, 2014 | 29 | 2014 |
Modulation of exosome‐mediated mRNA turnover by interaction of GTP‐binding protein 1 (GTPBP1) with its target mRNAs KC Woo, TD Kim, KH Lee, DY Kim, S Kim, HR Lee, HJ Kang, SJ Chung, ... The FASEB Journal 25 (8), 2757-2769, 2011 | 29 | 2011 |
TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease B Am Seo, D Kim, H Hwang, MS Kim, SX Ma, SH Kwon, SH Kweon, ... Neuron 109 (23), 3758-3774. e11, 2021 | 28 | 2021 |
Brazilin Isolated from Caesalpinia sappan suppresses nuclear envelope reassembly by inhibiting barrier-to-autointegration factor phosphorylation SH Kim, HN Lyu, YS Kim, YH Jeon, W Kim, S Kim, JK Lim, HW Lee, ... Journal of Pharmacology and Experimental Therapeutics 352 (1), 175-184, 2015 | 28 | 2015 |
Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation H Song, W Kim, JH Choi, SH Kim, D Lee, CH Park, S Kim, DY Kim, KT Kim Scientific reports 6 (1), 28634, 2016 | 23 | 2016 |
Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage–induced apoptosis CH Park, BH Choi, MW Jeong, S Kim, W Kim, YS Song, KT Kim Molecular biology of the cell 22 (8), 1398-1408, 2011 | 21 | 2011 |
Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity S Choi, D Kim, TI Kam, S Yun, S Kim, H Park, H Hwang, O Pletnikova, ... PLoS One 10 (12), e0143854, 2015 | 19 | 2015 |
Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease J Im, S Kim, YH Jeong, W Kim, D Lee, WS Lee, YT Chang, KT Kim, ... Medchemcomm 4 (2), 310-316, 2013 | 18 | 2013 |