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Jorge L. Del-Aguila
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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
Y Shi, K Yamada, SA Liddelow, ST Smith, L Zhao, W Luo, RM Tsai, ...
Nature 549 (7673), 523-527, 2017
7032017
A common haplotype lowers PU. 1 expression in myeloid cells and delays onset of Alzheimer's disease
K Huang, E Marcora, AA Pimenova, AF Di Narzo, M Kapoor, SC Jin, ...
Nature neuroscience 20 (8), 1052-1061, 2017
2792017
Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
L Piccio, Y Deming, JL Del-Águila, L Ghezzi, DM Holtzman, AM Fagan, ...
Acta neuropathologica 131 (6), 925-933, 2016
2502016
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
U Dube, JL Del-Aguila, Z Li, JP Budde, S Jiang, S Hsu, L Ibanez, ...
Nature neuroscience 22 (11), 1903-1912, 2019
1572019
Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers
Y Deming, Z Li, M Kapoor, O Harari, JL Del-Aguila, K Black, D Carrell, ...
Acta neuropathologica 133 (5), 839-856, 2017
1332017
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Y Deming, F Filipello, F Cignarella, C Cantoni, S Hsu, R Mikesell, Z Li, ...
Science translational medicine 11 (505), eaau2291, 2019
1232019
Single-nuclei RNA sequencing from human brain to study for Mendelian and sporadic AD
JL Del-Aguila, Z Li, U Dube, KA Mihindukulasuriya, JP Budde, ...
bioRxiv, 593756, 2019
96*2019
Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms
C Cruchaga, JL Del-Aguila, B Saef, K Black, MV Fernandez, J Budde, ...
Alzheimer's & Dementia 14 (2), 205-214, 2018
912018
Sex-specific genetic predictors of Alzheimer’s disease biomarkers
Y Deming, L Dumitrescu, LL Barnes, M Thambisetty, B Kunkle, KA Gifford, ...
Acta neuropathologica 136 (6), 857-872, 2018
562018
Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels
L Ibanez, U Dube, B Saef, J Budde, K Black, A Medvedeva, JL Del-Aguila, ...
BMC neurology 17 (1), 1-9, 2017
522017
Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis
BV Lananna, CA McKee, MW King, JL Del-Aguila, JM Dimitry, FHG Farias, ...
Science translational medicine 12 (574), eaax3519, 2020
482020
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
JL Del-Aguila, BA Benitez, Z Li, U Dube, KA Mihindukulasuriya, JP Budde, ...
Molecular neurodegeneration 14 (1), 1-13, 2019
462019
Alzheimer's disease: rare variants with large effect sizes
JL Del-Aguila, DC Koboldt, K Black, R Chasse, J Norton, RK Wilson, ...
Current opinion in genetics & development 33, 49-55, 2015
452015
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans
JL Del-Aguila, AL Beitelshees, RM Cooper-Dehoff, AB Chapman, ...
The pharmacogenomics journal 14 (1), 35-40, 2014
442014
Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure
Z Li, JL Del-Aguila, U Dube, J Budde, R Martinez, K Black, Q Xiao, ...
Genome medicine 10 (1), 1-19, 2018
432018
Assessment of the genetic architecture of Alzheimer’s disease risk in rate of memory decline
JL Del-Aguila, MV Fernández, S Schindler, L Ibanez, Y Deming, S Ma, ...
Journal of Alzheimer's Disease 62 (2), 745-756, 2018
412018
Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP
S Jiang, N Wen, Z Li, U Dube, J Del Aguila, J Budde, R Martinez, S Hsu, ...
Translational psychiatry 8 (1), 1-16, 2018
402018
The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion
Z Li, FHG Farias, U Dube, JL Del-Aguila, KA Mihindukulasuriya, ...
Acta neuropathologica 139 (1), 45-61, 2020
352020
Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging
Q Yan, K Nho, JL Del-Aguila, X Wang, SL Risacher, KH Fan, BE Snitz, ...
Molecular psychiatry 26 (1), 309-321, 2021
322021
Role of ABCA7 loss-of-function variant in Alzheimer's disease: a replication study in European–Americans
JL Del-Aguila, MV Fernández, J Jimenez, K Black, S Ma, Y Deming, ...
Alzheimer's research & therapy 7 (1), 1-4, 2015
302015
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