| ABC efflux pump-based resistance to chemotherapy drugs PDW Eckford, FJ Sharom Chemical reviews 109 (7), 2989-3011, 2009 | 682 | 2009 |
| Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP … PDW Eckford, C Li, M Ramjeesingh, CE Bear Journal of Biological Chemistry 287 (44), 36639-36649, 2012 | 343 | 2012 |
| The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids PDW Eckford, FJ Sharom Biochemical Journal 389 (2), 517-526, 2005 | 192 | 2005 |
| Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport PDW Eckford, FJ Sharom Biochemistry 47 (51), 13686-13698, 2008 | 128 | 2008 |
| Rescue of multiple class II CFTR mutations by elexacaftor+ tezacaftor+ ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator O Laselva, C Bartlett, TNA Gunawardena, H Ouyang, PDW Eckford, ... European Respiratory Journal 57 (6), 2021 | 121 | 2021 |
| Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates PDW Eckford, FJ Sharom Journal of biological chemistry 283 (19), 12840-12850, 2008 | 119 | 2008 |
| VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface PDW Eckford, M Ramjeesingh, S Molinski, S Pasyk, JF Dekkers, C Li, ... Chemistry & biology 21 (5), 666-678, 2014 | 113 | 2014 |
| Structural basis for alginate secretion across the bacterial outer membrane JC Whitney, ID Hay, C Li, PDW Eckford, H Robinson, MF Amaya, ... Proceedings of the National Academy of Sciences 108 (32), 13083-13088, 2011 | 110 | 2011 |
| Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue SV Molinski, S Ahmadi, W Ip, H Ouyang, A Villella, JP Miller, PS Lee, ... EMBO molecular medicine 9 (9), 1224-1243, 2017 | 106 | 2017 |
| The reconstituted Escherichia coli MsbA protein displays lipid flippase activity PDW Eckford, FJ Sharom Biochemical Journal 429 (1), 195-203, 2010 | 84 | 2010 |
| New insights into the drug binding, transport and lipid flippase activities of the p-glycoprotein multidrug transporter FJ Sharom, MR Lugo, PDW Eckford Journal of bioenergetics and biomembranes 37, 481-487, 2005 | 66 | 2005 |
| Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy PK Chiaw, PDW Eckford, CE Bear Essays in biochemistry 50, 233-248, 2011 | 63 | 2011 |
| P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors PDW Eckford, FJ Sharom Biochemistry and cell biology 84 (6), 1022-1033, 2006 | 60 | 2006 |
| Functional rescue of c. 3846G> A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary … O Laselva, PDW Eckford, C Bartlett, H Ouyang, TNA Gunawardena, ... Journal of Cystic Fibrosis 19 (5), 717-727, 2020 | 59 | 2020 |
| Functional rescue of F508del-CFTR using small molecule correctors S Molinski, PDW Eckford, S Pasyk, S Ahmadi, S Chin, CE Bear Frontiers in pharmacology 3, 160, 2012 | 54 | 2012 |
| The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF PDW Eckford, J McCormack, L Munsie, G He, S Stanojevic, SL Pereira, ... Journal of Cystic Fibrosis 18 (1), 35-43, 2019 | 53 | 2019 |
| Proton-dependent gating and proton uptake by Wzx support O-antigen-subunit antiport across the bacterial inner membrane ST Islam, PDW Eckford, ML Jones, T Nugent, CE Bear, C Vogel, JS Lam MBio 4 (5), 10.1128/mbio. 00678-13, 2013 | 47 | 2013 |
| Preclinical studies of a rare CF-causing mutation in the second nucleotide binding domain (c. 3700A> G) show robust functional rescue in primary nasal cultures by novel CFTR … O Laselva, J McCormack, C Bartlett, W Ip, TNA Gunawardena, H Ouyang, ... Journal of Personalized Medicine 10 (4), 209, 2020 | 25 | 2020 |
| A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients JX Jiang, L Wellhauser, O Laselva, I Utkina, Z Bozoky, T Gunawardena, ... Stem cell reports 16 (11), 2825-2837, 2021 | 24 | 2021 |
| Reconstitution of membrane transporters FJ Sharom, PDW Eckford Membrane Transporters: Methods and Protocols, 129-153, 2003 | 23 | 2003 |
