| NanoLuc complementation reporter optimized for accurate measurement of protein interactions in cells AS Dixon, MK Schwinn, MP Hall, K Zimmerman, P Otto, TH Lubben, ... ACS chemical biology 11 (2), 400-408, 2016 | 1050 | 2016 |
| NanoBRET A Novel BRET Platform for the Analysis of Protein–Protein Interactions T Machleidt, CC Woodroofe, MK Schwinn, J Méndez, MB Robers, ... ACS chemical biology 10 (8), 1797-1804, 2015 | 445 | 2015 |
| Effects of olefin substitution on the ring-closing metathesis of dienes TA Kirkland, RH Grubbs The Journal of Organic Chemistry 62 (21), 7310-7318, 1997 | 360 | 1997 |
| Target engagement and drug residence time can be observed in living cells with BRET MB Robers, ML Dart, CC Woodroofe, CA Zimprich, TA Kirkland, ... Nature communications 6 (1), 10091, 2015 | 248 | 2015 |
| Ring-closing metathesis in methanol and water TA Kirkland, DM Lynn, RH Grubbs The Journal of Organic Chemistry 63 (26), 9904-9909, 1998 | 238 | 1998 |
| Quantitative, wide-spectrum kinase profiling in live cells for assessing the effect of cellular ATP on target engagement JD Vasta, CR Corona, J Wilkinson, CA Zimprich, JR Hartnett, MR Ingold, ... Cell chemical biology 25 (2), 206-214. e11, 2018 | 212 | 2018 |
| Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals Y Su, JR Walker, Y Park, TP Smith, LX Liu, MP Hall, L Labanieh, R Hurst, ... Nature methods 17 (8), 852-860, 2020 | 131 | 2020 |
| Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging MP Hall, CC Woodroofe, MG Wood, I Que, M van’t Root, Y Ridwan, C Shi, ... Nature communications 9 (1), 132, 2018 | 120 | 2018 |
| Total synthesis of (+)-ambruticin S TA Kirkland, J Colucci, LS Geraci, MA Marx, M Schneider, DE Kaelin, ... Journal of the American Chemical Society 123 (49), 12432-12433, 2001 | 96 | 2001 |
| Fatal neurodissemination and SARS-CoV-2 tropism in K18-hACE2 mice is only partially dependent on hACE2 expression M Carossino, D Kenney, AK O’Connell, P Montanaro, AE Tseng, ... Viruses 14 (3), 535, 2022 | 78* | 2022 |
| Total synthesis of (+)-ambruticin S SM Berberich, RJ Cherney, J Colucci, C Courillon, LS Geraci, TA Kirkland, ... Tetrahedron 59 (35), 6819-6832, 2003 | 76 | 2003 |
| Diamine derivatives as inhibitors of leukotriene A4 hydrolase D Arnaiz, G Brown, E Claret, A Cleve, D Davey, W Guilford, SK Khim, ... US Patent 7,737,145, 2010 | 68 | 2010 |
| Coelenterazine analogues emit red-shifted bioluminescence with NanoLuc A Shakhmin, MP Hall, T Machleidt, JR Walker, KV Wood, TA Kirkland Organic & Biomolecular Chemistry 15 (40), 8559-8567, 2017 | 56 | 2017 |
| A bioluminogenic HDAC activity assay: validation and screening F Halley, J Reinshagen, B Ellinger, M Wolf, AL Niles, NJ Evans, ... Journal of biomolecular screening 16 (10), 1227-1235, 2011 | 50 | 2011 |
| Homogeneous assay for target engagement utilizing bioluminescent thermal shift ML Dart, T Machleidt, E Jost, MK Schwinn, MB Robers, C Shi, TA Kirkland, ... ACS medicinal chemistry letters 9 (6), 546-551, 2018 | 47 | 2018 |
| Deciphering the cellular targets of bioactive compounds using a chloroalkane capture tag R Friedman Ohana, TA Kirkland, CC Woodroofe, S Levin, HT Uyeda, ... ACS chemical biology 10 (10), 2316-2324, 2015 | 45 | 2015 |
| Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase TA Kirkland, M Adler, JG Bauman, M Chen, JZ Haeggström, B King, ... Bioorganic & medicinal chemistry 16 (9), 4963-4983, 2008 | 44 | 2008 |
| The luminescent HiBiT peptide enables selective quantitation of G protein–coupled receptor ligand engagement and internalization in living cells ME Boursier, S Levin, K Zimmerman, T Machleidt, R Hurst, BL Butler, ... Journal of Biological Chemistry 295 (15), 5124-5135, 2020 | 42 | 2020 |
| Improved deconvolution of protein targets for bioactive compounds using a palladium cleavable chloroalkane capture tag R Friedman Ohana, S Levin, MG Wood, K Zimmerman, ML Dart, ... ACS chemical biology 11 (9), 2608-2617, 2016 | 33 | 2016 |
| Three efficient methods for preparation of coelenterazine analogues A Shakhmin, MP Hall, JR Walker, T Machleidt, BF Binkowski, KV Wood, ... Chemistry–A European Journal 22 (30), 10369-10375, 2016 | 30 | 2016 |
