| Principles and applications of halogen bonding in medicinal chemistry and chemical biology R Wilcken, MO Zimmermann, A Lange, AC Joerger, FM Boeckler Journal of medicinal chemistry 56 (4), 1363-1388, 2013 | 1174 | 2013 |
| Small molecule induced reactivation of mutant p53 in cancer cells X Liu, R Wilcken, AC Joerger, IS Chuckowree, J Amin, J Spencer, ... Nucleic acids research 41 (12), 6034-6044, 2013 | 243 | 2013 |
| Halogen-enriched fragment libraries as leads for drug rescue of mutant p53 R Wilcken, X Liu, MO Zimmermann, TJ Rutherford, AR Fersht, AC Joerger, ... Journal of the American Chemical Society 134 (15), 6810-6818, 2012 | 243 | 2012 |
| Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency S Lovric, S Goncalves, HY Gee, B Oskouian, H Srinivas, WI Choi, S Shril, ... The Journal of clinical investigation 127 (3), 912-928, 2017 | 191 | 2017 |
| Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition R Wilcken, GZ Wang, FM Boeckler, AR Fersht Proceedings of the National Academy of Sciences 109 (34), 13584-13589, 2012 | 124 | 2012 |
| Using halogen bonds to address the protein backbone: a systematic evaluation R Wilcken, MO Zimmermann, A Lange, S Zahn, FM Boeckler Journal of computer-aided molecular design 26, 935-945, 2012 | 101 | 2012 |
| Structure of the SAS-6 cartwheel hub from Leishmania major M van Breugel, R Wilcken, SH McLaughlin, TJ Rutherford, CM Johnson Elife 3, e01812, 2014 | 67 | 2014 |
| Harnessing fluorine–sulfur contacts and multipolar interactions for the design of p53 mutant Y220C rescue drugs MR Bauer, RN Jones, MGJ Baud, R Wilcken, FM Boeckler, AR Fersht, ... ACS chemical biology 11 (8), 2265-2274, 2016 | 64 | 2016 |
| Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2 SM Vogel, MR Bauer, AC Joerger, R Wilcken, T Brandt, DB Veprintsev, ... Proceedings of the National Academy of Sciences 109 (42), 16906-16910, 2012 | 64 | 2012 |
| Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53 AC Joerger, MR Bauer, R Wilcken, MGJ Baud, H Harbrecht, TE Exner, ... Structure 23 (12), 2246-2255, 2015 | 58 | 2015 |
| Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties HA Mohamed, NMR Girgis, R Wilcken, MR Bauer, HN Tinsley, BD Gary, ... Journal of medicinal chemistry 54 (2), 495-509, 2011 | 58 | 2011 |
| Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C A Weiss, E Lorthiois, L Barys, KS Beyer, C Bomio-Confaglia, H Burks, ... Cancer Discovery 12 (6), 1500-1517, 2022 | 55 | 2022 |
| High accuracy quantum-chemistry-based calculation and blind prediction of macroscopic pKa values in the context of the SAMPL6 challenge P Pracht, R Wilcken, A Udvarhelyi, S Rodde, S Grimme Journal of Computer-Aided Molecular Design 32, 1139-1149, 2018 | 55 | 2018 |
| Addressing methionine in molecular design through directed sulfur–halogen bonds R Wilcken, MO Zimmermann, A Lange, S Zahn, B Kirchner, FM Boeckler Journal of chemical theory and computation 7 (7), 2307-2315, 2011 | 54 | 2011 |
| Machine learning estimates of natural product conformational energies M Rupp, MR Bauer, R Wilcken, A Lange, M Reutlinger, FM Boeckler, ... PLoS computational biology 10 (1), e1003400, 2014 | 41 | 2014 |
| Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery MO Zimmermann, A Lange, R Wilcken, MB Cieslik, TE Exner, AC Joerger, ... Future medicinal chemistry 6 (6), 617-639, 2014 | 40 | 2014 |
| Tracing the evolution of the p53 tetramerization domain AC Joerger, R Wilcken, A Andreeva Structure 22 (9), 1301-1310, 2014 | 38 | 2014 |
| JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors E Lorthiois, M Gerspacher, KS Beyer, A Vaupel, C Leblanc, R Stringer, ... Journal of medicinal chemistry 65 (24), 16173-16203, 2022 | 33 | 2022 |
| Targeting Histidine Side Chains in Molecular Design through Nitrogen–Halogen Bonds A Lange, MO Zimmermann, R Wilcken, S Zahn, FM Boeckler Journal of chemical information and modeling 53 (12), 3178-3189, 2013 | 27 | 2013 |
| Benchmarking different QM levels for usage with COSMO-RS J Reinisch, M Diedenhofen, R Wilcken, A Udvarhelyi, A Glöß Journal of Chemical Information and Modeling 59 (11), 4806-4813, 2019 | 26 | 2019 |
Frank M. BoecklerUniv. Professor, Lab for Molecular Design & Pharm. Biophysics, Eberhard Karls University TuebingenVerified email at uni-tuebingen.de
