| The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment AM Fajardo, GA Piazza, HN Tinsley Cancers 6 (1), 436-458, 2014 | 217 | 2014 |
| Suppression of Wnt/β-catenin signaling inhibits prostate cancer cell proliferation W Lu, HN Tinsley, A Keeton, Z Qu, GA Piazza, Y Li European journal of pharmacology 602 (1), 8-14, 2009 | 146 | 2009 |
| Chronic exposure to a high-fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice HB Eccleston, KK Andringa, AM Betancourt, AL King, SK Mantena, ... Antioxidants & redox signaling 15 (2), 447-459, 2011 | 141 | 2011 |
| Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling N Li, Y Xi, HN Tinsley, E Gurpinar, BD Gary, B Zhu, Y Li, X Chen, ... Molecular cancer therapeutics 12 (9), 1848-1859, 2013 | 132 | 2013 |
| Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors AH Abadi, TM Ibrahim, KM Abouzid, J Lehmann, HN Tinsley, BD Gary, ... Bioorganic & medicinal chemistry 17 (16), 5974-5982, 2009 | 128 | 2009 |
| Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of … HN Tinsley, BD Gary, AB Keeton, W Zhang, AH Abadi, RC Reynolds, ... Molecular cancer therapeutics 8 (12), 3331-3340, 2009 | 113 | 2009 |
| A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity GA Piazza, AB Keeton, HN Tinsley, BD Gary, JD Whitt, B Mathew, ... Cancer Prevention Research 2 (6), 572-580, 2009 | 106 | 2009 |
| Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin–mediated transcription in human breast tumor cells HN Tinsley, BD Gary, AB Keeton, W Lu, Y Li, GA Piazza Cancer prevention research 4 (8), 1275-1284, 2011 | 103 | 2011 |
| Colon tumor cell growth–inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition HN Tinsley, BD Gary, J Thaiparambil, N Li, W Lu, Y Li, YY Maxuitenko, ... Cancer Prevention Research 3 (10), 1303-1313, 2010 | 89 | 2010 |
| A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity JD Whitt, N Li, HN Tinsley, X Chen, W Zhang, Y Li, BD Gary, AB Keeton, ... Cancer prevention research 5 (6), 822-833, 2012 | 79 | 2012 |
| NSAIDs: old drugs reveal new anticancer targets GA Piazza, AB Keeton, HN Tinsley, JD Whitt, BD Gary, B Mathew, R Singh, ... Pharmaceuticals 3 (5), 1652-1667, 2010 | 79 | 2010 |
| Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach AH Abadi, DA Abouel-Ella, J Lehmann, HN Tinsley, BD Gary, GA Piazza, ... European journal of medicinal chemistry 45 (1), 90-97, 2010 | 70 | 2010 |
| Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties HA Mohamed, NMR Girgis, R Wilcken, MR Bauer, HN Tinsley, BD Gary, ... Journal of medicinal chemistry 54 (2), 495-509, 2011 | 58 | 2011 |
| New NSAID targets and derivatives for colorectal cancer chemoprevention HN Tinsley, WE Grizzle, A Abadi, A Keeton, B Zhu, Y Xi, GA Piazza Prospects for Chemoprevention of Colorectal Neoplasia: Emerging Role of Anti …, 2013 | 47 | 2013 |
| Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective AH Abadi, BD Gary, HN Tinsley, GA Piazza, M Abdel-Halim European journal of medicinal chemistry 45 (4), 1278-1286, 2010 | 45 | 2010 |
| cGMP signaling as a target for the prevention and treatment of breast cancer PF Windham, HN Tinsley Seminars in cancer biology 31, 106-110, 2015 | 33 | 2015 |
| Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives NS Ahmed, AH Ali, SM El-Nashar, BD Gary, AM Fajardo, HN Tinsley, ... European journal of medicinal chemistry 57, 329-343, 2012 | 20 | 2012 |
| Design and Synthesis of Substituted Pyridazinone‐1‐Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors HM Abdel‐Rahman, M Abdel‐Aziz, HN Tinsley, BD Gary, JC Canzoneri, ... Archiv der Pharmazie 349 (2), 104-111, 2016 | 15 | 2016 |
| Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido [2, 3-d] pyrimidine derivatives and their effects … AH Abadi, MS Hany, SA Elsharif, AAH Eissa, BDW Gary, HN Tinsley, ... Chemical and Pharmaceutical Bulletin 61 (4), 405-410, 2013 | 15 | 2013 |
| Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents AH Abadi, DA Abouel-Ella, NS Ahmed, BD Gary, JT Thaiparambil, ... Arzneimittelforschung 59 (8), 415-421, 2009 | 15 | 2009 |
