| A new amyloid β variant favoring oligomerization in Alzheimer's‐type dementia T Tomiyama, T Nagata, H Shimada, R Teraoka, A Fukushima, ... Annals of neurology 63 (3), 377-387, 2008 | 526 | 2008 |
| A mouse model of amyloid β oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo T Tomiyama, S Matsuyama, H Iso, T Umeda, H Takuma, K Ohnishi, ... Journal of Neuroscience 30 (14), 4845-4856, 2010 | 488 | 2010 |
| Inhibition of Amyloid β Protein Aggregation and Neurotoxicity by Rifampicin: ITS POSSIBLE FUNCTION AS A HYDROXYL RADICAL SCAVENGER (∗) T Tomiyama, A Shoji, K Kataoka, Y Suwa, S Asano, H Kaneko, N Endo Journal of Biological Chemistry 271 (12), 6839-6844, 1996 | 403 | 1996 |
| Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form H Kanemitsu, T Tomiyama, H Mori Neuroscience letters 350 (2), 113-116, 2003 | 335 | 2003 |
| Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission … J Maeda, B Ji, T Irie, T Tomiyama, M Maruyama, T Okauchi, M Staufenbiel, ... Journal of Neuroscience 27 (41), 10957-10968, 2007 | 323 | 2007 |
| Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo T Umeda, T Tomiyama, N Sakama, S Tanaka, MP Lambert, WL Klein, ... Journal of neuroscience research 89 (7), 1031-1042, 2011 | 309 | 2011 |
| Rifampicin prevents the aggregation and neurotoxicity of amyloid β protein in vitro T Tomiyama, S Asano, Y Suwa, T Morita, K Kataoka, H Mori, N Endo Biochemical and Biophysical Research Communications 204 (1), 76-83, 1994 | 229 | 1994 |
| Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues. T Tomiyama, S Asano, Y Furiya, T Shirasawa, N Endo, H Mori Journal of Biological Chemistry 269 (14), 10205-10208, 1994 | 193 | 1994 |
| Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy K Boekhoorn, D Terwel, B Biemans, P Borghgraef, O Wiegert, ... Journal of Neuroscience 26 (13), 3514-3523, 2006 | 191 | 2006 |
| The E693Δ mutation in amyloid precursor protein increases intracellular accumulation of amyloid β oligomers and causes endoplasmic reticulum stress-induced apoptosis in … K Nishitsuji, T Tomiyama, K Ishibashi, K Ito, R Teraoka, MP Lambert, ... The American journal of pathology 174 (3), 957-969, 2009 | 143 | 2009 |
| In vivo positron emission tomographic imaging of glial responses to amyloid-β and tau pathologies in mouse models of Alzheimer's disease and related disorders J Maeda, MR Zhang, T Okauchi, B Ji, M Ono, S Hattori, K Kumata, N Iwata, ... Journal of Neuroscience 31 (12), 4720-4730, 2011 | 140 | 2011 |
| Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers T Umeda, K Ono, A Sakai, M Yamashita, M Mizuguchi, WL Klein, ... Brain 139 (5), 1568-1586, 2016 | 125 | 2016 |
| Rifampicin inhibits the toxicity of pre-aggregated amyloid peptides by binding to peptide fibrils and preventing amyloid-cell interaction T TOMIYAMA, H KANEKO, K KATAOKA, S ASANO, N ENDO Biochemical Journal 322 (3), 859-865, 1997 | 113 | 1997 |
| Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo H Takuma, T Tomiyama, K Kuida, H Mori Journal of Neuropathology & Experimental Neurology 63 (3), 255-261, 2004 | 98 | 2004 |
| Tau‐4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice K Sennvik, K Boekhoorn, R Lasrado, D Terwel, S Verhaeghe, H Korr, ... The FASEB Journal 21 (9), 2149-2161, 2007 | 88 | 2007 |
| The domestic cat as a natural animal model of Alzheimer’s disease JK Chambers, T Tokuda, K Uchida, R Ishii, H Tatebe, E Takahashi, ... Acta neuropathologica communications 3, 1-14, 2015 | 85 | 2015 |
| Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice T Umeda, T Tomiyama, E Kitajima, T Idomoto, S Nomura, MP Lambert, ... Life sciences 91 (23-24), 1169-1176, 2012 | 85 | 2012 |
| Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice T Umeda, S Maekawa, T Kimura, A Takashima, T Tomiyama, H Mori Acta neuropathologica 127, 685-698, 2014 | 78 | 2014 |
| Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis Y Hashimoto, T Tomiyama, Y Yamano, H Mori The American journal of pathology 163 (1), 101-110, 2003 | 77 | 2003 |
| Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons T Umeda, EM Ramser, M Yamashita, K Nakajima, H Mori, MA Silverman, ... Acta neuropathologica communications 3, 1-15, 2015 | 72 | 2015 |
